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Found 645 with Last Name = 'miura' and Initial = 'j'
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204291(CHEMBL3953104 | US20230295171, Example 76)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204296(CHEMBL3941633 | US20230295171, Example 75)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM620222(BDBM50204292 | US20230295171, Example 82)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204293(CHEMBL3983415 | US20230295171, Example 25)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413341((S)-6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl...)
Affinity DataIC50:  1.78nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant full length N-terminal GST-tagged SYK cytoplasmic domain expressed in baculovirus expression system by Z'-LYTE assayMore data for this Ligand-Target Pair
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413007(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50:  2.14nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413146(2-fluoro-4-(5-hydroxy-1-(5-(morpholine-4-carbonyl)...)
Affinity DataIC50:  2.24nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204295(CHEMBL3944381)
Affinity DataIC50:  2.30nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413152(2-fluoro-4-(5-hydroxy-1-(5-(4-methyl-4,7-diazaspir...)
Affinity DataIC50:  2.34nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413246(4-(5-hydroxy-1-(5-(4-propylpiperazine-1-carbonyl)p...)
Affinity DataIC50:  2.51nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413353((S)-6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyr...)
Affinity DataIC50:  2.51nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413134(2-fluoro-4-(5-hydroxy-1-(5-(4-methylpiperazine-1-c...)
Affinity DataIC50:  2.57nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413193((S)-4-(1-(5-(3-((2,2-difluoroethyl)(methyl)amino)p...)
Affinity DataIC50:  2.82nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413139(2-fluoro-4-(5-hydroxy-1-(5-(4-methyl-4,7-diazaspir...)
Affinity DataIC50:  2.88nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413210((R)-4-(1-(5-(3-((2,2-difluoroethyl)(methyl)amino)p...)
Affinity DataIC50:  2.95nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetMicrotubule-associated protein 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167916(CHEMBL3798615)
Affinity DataIC50:  3nMAssay Description:Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413140((S)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50:  3.02nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413063(4-(1-(5-(4-(2,2-difluoroethyl)piperazine-1-carbony...)
Affinity DataIC50:  3.09nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204288(CHEMBL3925430 | US20230295171, Example 88)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413069(4-(5-hydroxy-1-(5-(4-(2,2,2-trifluoroethyl)piperaz...)
Affinity DataIC50:  3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413199((R)-2-fluoro-4-(5-hydroxy-1-(5-(octahydropyrrolo[1...)
Affinity DataIC50:  3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413169((S)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50:  3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413158((S)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50:  3.16nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetTyrosine-protein kinase SYK(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50204290(CHEMBL3979920 | US11077111, Compound IIIa | US2023...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human C-terminal 6His-tagged SYK (356 to 635 residues) expressed in Sf9 insect cells using 5-carboxyfluorescein(FAM)-EEPLYWSFPAKKK-NH2 ...More data for this Ligand-Target Pair
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413194(6-(4-(4-cyano-3-fluoro-2-methylphenyl)-5-hydroxy-1...)
Affinity DataIC50:  3.24nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413340(6-(4-(4-cyano-2-fluorophenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50:  3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413128((R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50:  3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413200(4-(5-hydroxy-1-(5-(octahydropyrrolo[1,2-a]pyrazine...)
Affinity DataIC50:  3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413188(6-(4-(4-cyano-5-fluoro-2-methylphenyl)-5-hydroxy-1...)
Affinity DataIC50:  3.31nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413239((S)-4-(1-(5-(4-ethyl-2-methylpiperazine-1-carbonyl...)
Affinity DataIC50:  3.39nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413187((S)-2-fluoro-4-(5-hydroxy-1-(5-(3-(methyl(2,2,2-tr...)
Affinity DataIC50:  3.39nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413157(2-fluoro-4-(5-hydroxy-1-(5-(morpholine-4-carbonyl)...)
Affinity DataIC50:  3.39nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM412995(4-(1-(5-(6,6-difluoro-4-methyl-1,4-diazepane-1-car...)
Affinity DataIC50:  3.47nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413335((R)-6-(4-(4-cyanophenyl)-5-hydroxy-1H-pyrazol-1-yl...)
Affinity DataIC50:  3.47nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413347((R)-6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyr...)
Affinity DataIC50:  3.55nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413023(4-(5-hydroxy-1-(5-(3,3,4-trimethylpiperazine-1-car...)
Affinity DataIC50:  3.63nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413145(2-fluoro-4-(5-hydroxy-1-(5-(pyrrolidine-1-carbonyl...)
Affinity DataIC50:  3.63nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413164((R)-4-(1-(5-(3,4-dimethylpiperazine-1-carbonyl)pyr...)
Affinity DataIC50:  3.63nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413205(2-fluoro-4-(5-hydroxy-1-(5-(3-(piperidin-1-yl)azet...)
Affinity DataIC50:  3.72nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413246(4-(5-hydroxy-1-(5-(4-propylpiperazine-1-carbonyl)p...)
Affinity DataIC50:  3.89nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413011(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50:  3.89nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413121(4-(1-(5-(3-(dimethylamino)azetidine-1-carbonyl)pyr...)
Affinity DataIC50:  3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413104(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50:  3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413098(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50:  3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413223(6-(5-hydroxy-4-(2-methoxypyridin-4-yl)-1H-pyrazol-...)
Affinity DataIC50:  3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413221((R)-4-(1-(5-(4-ethyl-3-methylpiperazine-1-carbonyl...)
Affinity DataIC50:  3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetEgl nine homolog 1 [181-417](Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM413148(6-(4-(4-cyano-2-methylphenyl)-5-hydroxy-1H-pyrazol...)
Affinity DataIC50:  3.98nMAssay Description:The IC50 values for the PHD2 enzyme (residues 181-417) were determined by mixing increasing amounts of inhibitor with a fixed amount of enzyme (5 nM,...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails US Patent
TargetMicrotubule-associated protein 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167926(CHEMBL3798871)
Affinity DataIC50:  4nMAssay Description:Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMicrotubule-associated protein 2(Homo sapiens (Human))
Takeda California

Curated by ChEMBL
LigandPNGBDBM50167915(CHEMBL3798727)
Affinity DataIC50:  4nMAssay Description:Reversal inhibition of full length recombinant human MetAP2 expressed in baculovirus infected insect Sf9 cells using Met-AMC as substrate measured fo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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