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Found 66 with Last Name = 'moschetta' and Initial = 'a'
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataEC50:  200nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299251(2-(5-chlorothiophen-2-ylthio)-2-methylpropanoic ac...)
Affinity DataEC50:  1.80E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299252(2-[(5-Bromo-1,3-benzothiazol-2-yl)thio]-2-methylpr...)
Affinity DataEC50:  2.50E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299253((S)-2-(5-methoxybenzo[d]thiazol-2-ylthio)propanoic...)
Affinity DataEC50:  1.90E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299254(CHEMBL566082 | rac-2-[(5-Bromo-1,3-benzothiazol-2-...)
Affinity DataEC50:  9.30E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299255(CHEMBL573896 | rac-2-[(5-Chloro-1,3-benzothiazol-2...)
Affinity DataEC50:  9.30E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299256(CHEMBL575347 | rac-2-[(6-Ethoxy-1,3-benzothiazol-2...)
Affinity DataEC50:  1.48E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299257(CHEMBL583932 | rac-[(5-Chloro-1,3-benzothiazol-2-y...)
Affinity DataEC50:  1.43E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299258(CHEMBL575755 | rac-2-[(6-Ethoxy-1,3-benzothiazol-2...)
Affinity DataEC50:  9.80E+3nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299259(2-[(6-Chloro-1,3-benzothiazol-2-yl)thio]-2-methylp...)
Affinity DataEC50:  3.89E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299260(2-(5-chlorobenzo[d]thiazol-2-ylthio)-2-methylpropa...)
Affinity DataEC50:  3.59E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299261(2-[(6-Trifluoromethyl-1,3-benzothiazol-2-yl)thio]-...)
Affinity DataEC50:  3.61E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299262(2-[(5-Cyano-1,3-benzothiazol-2-yl)thio]-2-methylpr...)
Affinity DataEC50:  4.63E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299263(2-[(5-Methoxy-1,3-benzothiazol-2-yl)thio]-2-methyl...)
Affinity DataEC50:  4.58E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM28699(2-(4-chlorophenoxy)-2-methylpropanoic acid | CHEMB...)
Affinity DataEC50:  5.50E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299264(2-[(6-Bromo-1,3-benzothiazol-2-yl)thio]-2-methylpr...)
Affinity DataEC50:  4.58E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299253((S)-2-(5-methoxybenzo[d]thiazol-2-ylthio)propanoic...)
Affinity DataEC50:  3.33E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299265((R)-2-(5-methoxybenzo[d]thiazol-2-ylthio)propanoic...)
Affinity DataEC50:  5.73E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299266((S)-2-(5-chlorobenzo[d]thiazol-2-ylthio)propanoic ...)
Affinity DataEC50:  5.59E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299267(2-[(6-Ethoxy-1,3-benzothiazol-2-yl)thio]-2-methylp...)
Affinity DataEC50:  6.93E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299266((S)-2-(5-chlorobenzo[d]thiazol-2-ylthio)propanoic ...)
Affinity DataEC50:  6.25E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299268(CHEMBL575316 | rac-2-[(6-Bromo-1,3-benzothiazol-2-...)
Affinity DataEC50:  8.43E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50299269((R)-2-(5-chlorobenzo[d]thiazol-2-ylthio)propanoic ...)
Affinity DataEC50:  7.35E+4nMAssay Description:Agonist activity at human PPARalpha expressed in HEK293 cells assessed as receptor transactivation at by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  1.00E+4nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM53721((4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dim...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  150nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50:  140nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550153(CHEMBL4758363)
Affinity DataEC50:  3.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550154(CHEMBL4740844)
Affinity DataEC50:  4.70E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  7.00E+3nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550155(CHEMBL4740500)
Affinity DataEC50:  600nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetBile acid receptor(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550156(CHEMBL4790262)
Affinity DataEC50:  400nMAssay Description:Agonist activity at glutathione transferase-tagged human FXR-LBD using biotinylated Src-1 peptide incubated for 30 mins by recruitment coactivator as...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21674((4R)-4-[(1S,2S,5R,7S,9R,10R,11S,14R,15R)-5,9-dihyd...)
Affinity DataEC50:  3.30E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM53721((4R)-4-[(3R,5S,7S,8R,9S,10S,13R,14S,17R)-10,13-dim...)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM21675((4R)-4-[(1S,2S,5R,7S,8R,9R,10S,11S,14R,15R)-8-ethy...)
Affinity DataEC50:  1.50E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300199(6alpha-ethyl-23(S)-methyl-cholic acid | CHEMBL5676...)
Affinity DataEC50:  900nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550153(CHEMBL4758363)
Affinity DataEC50:  4.15E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550154(CHEMBL4740844)
Affinity DataEC50:  6.20E+4nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50300201(3alpha,7alpha,12alpha-Trihydroxy-6alpha-ethyl-5bet...)
Affinity DataEC50:  5.00E+3nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550155(CHEMBL4740500)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled bile acid receptor 1(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550156(CHEMBL4790262)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at TGR5 in human NCI-H716 cells assessed as stimulation of intracellular cAMP accumulation incubated for 60 mins by HTR-FRET assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNuclear receptor subfamily 1 group I member 3(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50030476(CHEMBL458603)
Affinity DataEC50:  5nMAssay Description:Agonist activity at human CARMore data for this Ligand-Target Pair
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetOxysterols receptor LXR-beta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM19993(CHEMBL62136 | N-[4-(1,1,1,3,3,3-hexafluoro-2-hydro...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at human LXR-betaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-alphaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Universit£

Curated by ChEMBL
LigandPNGBDBM50099491(2-(4-(2-(3-cyclohexyl-1-(4-cyclohexylbutyl)ureido)...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at human PPAR-alphaMore data for this Ligand-Target Pair
TargetPeroxisome proliferator-activated receptor delta(Homo sapiens (Human))
Tes Pharma

Curated by ChEMBL
LigandPNGBDBM50550152(CHEMBL4758064)
Affinity DataEC50: >1.00E+5nMAssay Description:Agonist activity at human PPAR-deltaMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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