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Target
Peroxisome proliferator-activated receptor alpha
Ligand
BDBM50299257
Substrate
n/a
Meas. Tech.
ChEMBL_589587 (CHEMBL1052140)
EC50
14300±n/a nM
Citation
 Giampietro, L; Ammazzalorso, A; Giancristofaro, A; Lannutti, F; Bettoni, G; De Filippis, B; Fantacuzzi, M; Maccallini, C; Petruzzelli, M; Morgano, A; Moschetta, A; Amoroso, R Synthesis and biological evaluation of 2-heteroarylthioalkanoic acid analogues of clofibric acid as peroxisome proliferator-activated receptor alpha agonists. J Med Chem 52:6224-32 (2009) [PubMed]  Article 
Target
Name:
Peroxisome proliferator-activated receptor alpha
Synonyms:
NR1C1 | Nuclear receptor subfamily 1 group C member 1 | PPAR | PPAR alpha/gamma | PPAR-alpha | PPARA | PPARA_HUMAN | Peroxisome Proliferator-Activated Receptor alpha | Peroxisome proliferator-activated receptor | Peroxisome proliferator-activated receptor alpha (PPAR alpha)
Type:
Enzyme
Mol. Mass.:
52222.08
Organism:
Homo sapiens (Human)
Description:
Q07869
Residue:
468
Sequence:
MVDTESPLCPLSPLEAGDLESPLSEEFLQEMGNIQEISQSIGEDSSGSFGFTEYQYLGSCPGSDGSVITDTLSPASSPSSVTYPVVPGSVDESPSGALNIECRICGDKASGYHYGVHACEGCKGFFRRTIRLKLVYDKCDRSCKIQKKNRNKCQYCRFHKCLSVGMSHNAIRFGRMPRSEKAKLKAEILTCEHDIEDSETADLKSLAKRIYEAYLKNFNMNKVKARVILSGKASNNPPFVIHDMETLCMAEKTLVAKLVANGIQNKEAEVRIFHCCQCTSVETVTELTEFAKAIPGFANLDLNDQVTLLKYGVYEAIFAMLSSVMNKDGMLVAYGNGFITREFLKSLRKPFCDIMEPKFDFAMKFNALELDDSDISLFVAAIICCGDRPGLLNVGHIEKMQEGIVHVLRLHLQSNHPDDIFLFPKLLQKMADLRQLVTEHAQLVQIIKKTESDAALHPLLQEIYRDMY
  
Inhibitor
Name:
BDBM50299257
Synonyms:
CHEMBL583932 | rac-[(5-Chloro-1,3-benzothiazol-2-yl)thio](phenyl)acetic Acid
Type:
Small organic molecule
Emp. Form.:
C15H10ClNO2S2
Mol. Mass.:
335.828
SMILES:
OC(=O)C(Sc1nc2cc(Cl)ccc2s1)c1ccccc1
Structure:
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