Compile Data Set for Download or QSAR
maximum 50k data
Found 164 with Last Name = 'murkit' and Initial = 'g'
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412939(CHEMBL479463 | GSK-256471)
Affinity DataKi:  1nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412941(CHEMBL521416)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412940(CHEMBL519770)
Affinity DataKi:  1.26nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412942(CHEMBL480249)
Affinity DataKi:  1.58nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412943(CHEMBL480818)
Affinity DataKi:  2nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412944(CHEMBL479652)
Affinity DataKi:  3.16nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412945(CHEMBL516441)
Affinity DataKi:  3.98nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412947(5-(3-METHYL-1-TRIAZENO)IMIDAZOLE-4-CARBOXAMIDE)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412946(CHEMBL517691)
Affinity DataKi:  5.01nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412949(CHEMBL519790)
Affinity DataKi:  6.31nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412948(CHEMBL480248)
Affinity DataKi:  6.31nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412950(CHEMBL479450)
Affinity DataKi:  7.94nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50051295((S)-3-methyl-2-phenyl-N-(1-phenylpropyl)quinoline-...)
Affinity DataKi:  7.94nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412951(CHEMBL482006)
Affinity DataKi:  10nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412952(CHEMBL480628 | GSK-172981)
Affinity DataKi:  10nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412953(CHEMBL479449)
Affinity DataKi:  15.8nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuromedin-K receptor(Homo sapiens (Human))
Neuroscience Cedd Glaxosmithkline Research & Development

Curated by ChEMBL
LigandPNGBDBM50412938(CHEMBL520086)
Affinity DataKi:  251nMAssay Description:Binding affinity to NK3 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096484((4S,6R)-6-Allyl-4-(naphthalene-2-sulfonyl)-5-oxo-h...)
Affinity DataIC50:  0.0360nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066997((3aS,6R)-6-Allyl-4-methanesulfonyl-5-oxo-hexahydro...)
Affinity DataIC50:  0.0470nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153990(4-[2-(4-Ethoxy-phenyl)-pyrazolo[1,5-b]pyridazin-3-...)
Affinity DataIC50:  0.440nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50066999((S)-3,3-Diethyl-2-[4-(4-methyl-piperazine-1-carbon...)
Affinity DataIC50:  0.450nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096486(CHEMBL2367646 | benzyl (3aS,6aR)-4-acetyl-6-allyl-...)
Affinity DataIC50:  0.690nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096488((1S,3R)-1-(Naphthalene-2-sulfonyl)-4-(3-piperidin-...)
Affinity DataIC50:  1nMAssay Description:Binding affinity for dopamine D4-like receptor labelled with [3H]YM-09151-2 in retinaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096488((1S,3R)-1-(Naphthalene-2-sulfonyl)-4-(3-piperidin-...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096487((3R,6aS)-3-Allyl-2-oxo-hexahydro-pyrrolo[3,2-b]pyr...)
Affinity DataIC50:  2nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153994(3-(4-Methanesulfonyl-phenyl)-2-phenyl-pyrazolo[1,5...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153982(2-(4-Ethoxy-phenyl)-3-(4-methanesulfonyl-phenyl)-p...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096483((3R,6aS)-1-Methanesulfonyl-4-(3-piperidin-1-yl-pro...)
Affinity DataIC50:  3nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastase at a concentration of 10 uMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153987(4-[2-(4-Fluoro-phenyl)-pyrazolo[1,5-b]pyridazin-3-...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153989(3-(4-Methanesulfonyl-phenyl)-2-(4-methoxy-phenyl)-...)
Affinity DataIC50: <10nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50061024((2-Methyl-1-{(S)-oxo-[(S)-2-((S)-3,3,3-trifluoro-1...)
Affinity DataIC50: >10nMAssay Description:In vitro inhibitory activity in human whole blood (HWB) elastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153981(4-[2-(4-Ethoxy-phenyl)-6-methylsulfanyl-pyrazolo[1...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153997(3-(4-Methanesulfonyl-phenyl)-2-p-tolyl-pyrazolo[1,...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50098095((3S,3aR,6aS)-3-Isopropyl-1-methanesulfonyl-5-((E)-...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153991(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50:  24nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50098094((3R,6aR)-3-Isopropyl-1-methanesulfonyl-5-((E)-4-pi...)
Affinity DataIC50:  26nMAssay Description:Inhibitory concentration against ElastaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153992(4-[2-(4-Fluoro-phenyl)-6-methoxy-pyrazolo[1,5-b]py...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096490((3aS,6R)-6-Allyl-4-hexyl-5-oxo-hexahydro-pyrrolo[3...)
Affinity DataIC50:  29nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096485((3aS,6R)-6-Allyl-4-ethylcarbamoyl-5-oxo-hexahydro-...)
Affinity DataIC50:  31nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153980(3-(4-Methanesulfonyl-phenyl)-6-methyl-2-phenyl-pyr...)
Affinity DataIC50: <31nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM22369(4-(4-methanesulfonylphenyl)-3-phenyl-2,5-dihydrofu...)
Affinity DataIC50:  32nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153998(2-(3-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-p...)
Affinity DataIC50:  34nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153985(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-p...)
Affinity DataIC50:  39nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153984(6-Ethoxy-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-...)
Affinity DataIC50:  43nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153996(6-Ethyl-2-(4-fluoro-phenyl)-3-(4-methanesulfonyl-p...)
Affinity DataIC50:  48nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153999(3-(4-Methanesulfonyl-phenyl)-6-methoxy-2-p-tolyl-p...)
Affinity DataIC50:  50nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153988(2-(4-Fluoro-phenyl)-3-(4-methanesulfonyl-phenyl)-6...)
Affinity DataIC50:  51nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50153983(2-(4-Fluoro-phenyl)-6-isopropoxy-3-(4-methanesulfo...)
Affinity DataIC50:  57nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataIC50:  68nMAssay Description:Inhibition of human cyclooxygenase-2 expressed in COS cellsMore data for this Ligand-Target Pair
TargetNeutrophil elastase(Homo sapiens (Human))
Glaxowellcome Medicines Research Centre

Curated by ChEMBL
LigandPNGBDBM50096489((3aS,6R)-6-Allyl-4-formyl-5-oxo-hexahydro-pyrrolo[...)
Affinity DataIC50:  94nMAssay Description:In vitro inhibitory activity against human neutrophil elastase (HNE)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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