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Found 1266 with Last Name = 'murphy' and Initial = 'ea'
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239493(CHEMBL4103497 | US10329302, Example 312 | US107935...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239491(CHEMBL4083655 | US10329302, Example 173 | US107935...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239506(CHEMBL4071526 | US10329302, Example 188 | US107935...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 in human whole blood assessed as reduction R848-induced IL-6 secretion by measuring plasma protein binding corrected IC50 preincu...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239499(CHEMBL4081711 | US10329302, Example 344 | US107935...)
Affinity DataIC50:  2nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production by measuring plasma protein binding corrected IC50 af...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239497(CHEMBL4084228 | US10329302, Example 271 | US107935...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239492(CHEMBL4070515 | US10329302, Example 211 | US107935...)
Affinity DataIC50:  2.70nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239505(CHEMBL4061801 | US10329302, Example 248 | US107935...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239488(CHEMBL4092338 | US10329302, Example 26 | US1079357...)
Affinity DataIC50:  4.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239496(CHEMBL4075552 | US10329302, Example 264 | US107935...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239504(CHEMBL4061890 | US10329302, Example 262 | US107935...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50292791(4-{3-[2-{2-[({2-[(4-Acetylpiperazin-1-yl)methyl]be...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239500(CHEMBL4066705 | US10329302, Example 337 | US107935...)
Affinity DataIC50:  6.5nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239489(CHEMBL4100091 | US10329302, Example 121 | US107935...)
Affinity DataIC50:  7.60nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239507(CHEMBL4091434 | US10329302, Example 246 | US107935...)
Affinity DataIC50:  9nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50292792(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(morph...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50226793(4-(3-(1-benzhydryl-5-chloro-2-(2-((2,6-dimethylphe...)
Affinity DataIC50:  10nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239494(CHEMBL4079243 | US10329302, Example 340 | US107935...)
Affinity DataIC50:  12nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239498(CHEMBL4093120 | US10329302, Example 189 | US107935...)
Affinity DataIC50:  13nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50292790(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(piper...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239508(CHEMBL4085199 | US10329302, Example 309 | US107935...)
Affinity DataIC50:  17nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50292789(4-[3-(5-Chloro-1-(diphenylmethyl)-2-{2-[({2-[(4-me...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50292793(4-(3-{5-Chloro-1-(diphenylmethyl)-2-[2-({[2-(hydro...)
Affinity DataIC50:  22nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239490(CHEMBL4073250 | US10329302, Example 122 | US117024...)
Affinity DataIC50:  24nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50247699(4-(3-(1-benzhydryl-5-chloro-2-(2-(o-tolylmethylsul...)
Affinity DataIC50:  26nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239493(CHEMBL4103497 | US10329302, Example 312 | US107935...)
Affinity DataIC50:  28nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239495(CHEMBL4076912 | US10329302, Example 247 | US107935...)
Affinity DataIC50:  29nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50292794(4-{3-[5-Chloro-2-{2-[({2-[(diethylamino)methyl]ben...)
Affinity DataIC50:  30nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239506(CHEMBL4071526 | US10329302, Example 188 | US107935...)
Affinity DataIC50:  30nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239491(CHEMBL4083655 | US10329302, Example 173 | US107935...)
Affinity DataIC50:  37nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytosolic phospholipase A2(Homo sapiens (Human))
Wyeth Research

Curated by ChEMBL
LigandPNGBDBM50226792(4-(3-(1-benzhydryl-5-chloro-2-(2-((3,4-dichlorophe...)
Affinity DataIC50:  40nMAssay Description:Inhibition of human cytosolic PLA2alpha by GLU micelle assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239492(CHEMBL4070515 | US10329302, Example 211 | US107935...)
Affinity DataIC50:  52nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239497(CHEMBL4084228 | US10329302, Example 271 | US107935...)
Affinity DataIC50:  52nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239509(CHEMBL4086222)
Affinity DataIC50:  72nMAssay Description:Inhibition of N-terminal His6-tagged human full length IRAK4 preincubated for 20 mins followed by biotinylated-AGAGRDKYKTLRQIR substrate addition in ...More data for this Ligand-Target Pair
TargetInterleukin-1 receptor-associated kinase 4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50239505(CHEMBL4061801 | US10329302, Example 248 | US107935...)
Affinity DataIC50:  87nMAssay Description:Inhibition of IRAK4 in human PBMC assessed as reduction in R848-stimulated TNF alpha production after 3 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572092((R)-2-((1-(4- propionamidobenzoyl)pyrrolidin-3- yl...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572092((R)-2-((1-(4- propionamidobenzoyl)pyrrolidin-3- yl...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCDK-activating kinase assembly factor MAT1/Cyclin-H/Cyclin-dependent kinase 7(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572092((R)-2-((1-(4- propionamidobenzoyl)pyrrolidin-3- yl...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572075((R)-2-((1-(4- acrylamidobenzoyl)pyrrolidin-3- yl)a...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572075((R)-2-((1-(4- acrylamidobenzoyl)pyrrolidin-3- yl)a...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572094((R)-N,N-dimethyl-2-((1-(4- propionamidobenzoyl)pyr...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572094((R)-N,N-dimethyl-2-((1-(4- propionamidobenzoyl)pyr...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572095((R)-N-(4-(3-((7-oxo-7,8- dihydropyrido[2,3-d]pyrim...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-K/Cyclin-dependent kinase 12(Homo sapiens (Human))
Kinnate Biopharma

US Patent
LigandPNGBDBM572096((R)-N-(4-(3-((8-isopropyl-7-oxo-7,8- dihydropyrido...)
Affinity DataIC50: <100nMAssay Description:A radiometric protein kinase assay (33PanQinaseŽ Activity Assay) was used for measuring the kinase activity of the three protein kinases. All kinase ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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