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Found 202 with Last Name = 'nicolaou' and Initial = 'i'
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21400(CHEMBL192571 | N-[(4-{[(2R)-4-(dimethylamino)-1-(p...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13997(5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy...)
Affinity DataKi:  0.920nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
LigandPNGBDBM13996(4-amino-5-{3-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50612100(CHEMBL5279725)
Affinity DataKi:  2.40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM13990(5-{2-fluoro-5-[(1E)-3-[3-hydroxy-2-(methoxycarbony...)
Affinity DataKi:  6.90nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  8nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13954(3-({5-[(2S)-3-{4-[(2-carboxyphenyl)amidoformic aci...)
Affinity DataKi:  22nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Mi...More data for this Ligand-Target Pair
LigandPNGBDBM50087883(CHEMBL3426930)
Affinity DataKi:  25nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21447(4-(4-{[2-(4-chlorophenyl)phenyl]methyl}piperazin-1...)
Affinity DataKi:  30nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50270877((R)-4-(4-((2-(4-chlorophenyl)-5,5-dimethylcyclohex...)
Affinity DataKi:  36nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
LigandPNGBDBM50131547(2-(N-(4-(2-acetamido-3-(4-(5-chloro-3-hydroxy-2-(m...)
Affinity DataKi:  40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Michaelis-Menten analysisMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM21400(CHEMBL192571 | N-[(4-{[(2R)-4-(dimethylamino)-1-(p...)
Affinity DataKi:  62nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM50612075(CHEMBL5288197)
Affinity DataKi:  107nMAssay Description:Inhibition of human ALR2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using D,L-glyceraldehyde as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  180nMAssay Description:Binding affinity to MCL1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13611(2-(carboxymethoxy)-5-[(2S)-2-[(2S)-2-(3-formamidop...)
Affinity DataKi:  250nMAssay Description:Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
LigandPNGBDBM50118750(2-(Oxalyl-amino)-6-phenethyl-4,5,6,7-tetrahydro-th...)
Affinity DataKi:  270nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50118792(2-(OXALYL-AMINO)-4,5,6,7-TETRAHYDRO-THIENO[2,3-C]P...)
Affinity DataKi:  290nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  320nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM23223(7-[8-formyl-1,6,7-trihydroxy-3-methyl-5-(propan-2-...)
Affinity DataKi:  480nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50612099(CHEMBL5278790)
Affinity DataKi:  600nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50612085(CHEMBL5269879)
Affinity DataKi:  930nMAssay Description:Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as subs...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM13609(2-{4-[(2S)-2-[(2S)-2-(3-formamidopropanoic acid)-3...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50112100(CHEMBL51202 | [4-[2-(2-tert-Butoxycarbonylamino-3-...)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM50612074(CHEMBL5280965)
Affinity DataKi:  2.00E+3nMAssay Description:Inhibition of human ALR2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50118765(3-(carboxyformamido)-5-(4-(carboxymethoxy)phenyl)t...)
Affinity DataKi:  2.50E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Rattus norvegicus (rat))TBA
LigandPNGBDBM13606((3S)-3-{[(1S)-1-{[(1S)-1-carbamoylpentyl]carbamoyl...)
Affinity DataKi:  5.00E+3nMAssay Description:Inhibition of rat recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50118796(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Affinity DataKi:  8.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
LigandPNGBDBM50118779(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Affinity DataKi:  3.70E+4nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50612085(CHEMBL5269879)
Affinity DataKi:  1.00E+5nMAssay Description:Inhibition of rat recombinant LAR expressed in Escherichia coli assessed as inhibition constant using pNPP as substrate incubated for 5 mins by liqui...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50612085(CHEMBL5269879)
Affinity DataKi:  1.20E+5nMAssay Description:Inhibition of human PTPalpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50118796(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Affinity DataKi:  1.80E+5nMAssay Description:Inhibition of PTPalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))TBA
LigandPNGBDBM50118796(6-(OXALYL-AMINO)-1H-INDOLE-5-CARBOXYLIC ACID | 6-(...)
Affinity DataKi:  4.50E+5nMAssay Description:Inhibition of LAR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))TBA
LigandPNGBDBM50118779(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Affinity DataKi:  2.00E+6nMAssay Description:Inhibition of LAR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50118779(3-(Oxalyl-amino)-thiophene-2-carboxylic acid | 3-(...)
Affinity DataKi:  2.00E+6nMAssay Description:Inhibition of PTPalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetDual specificity protein phosphatase 3(Homo sapiens (Human))TBA
LigandPNGBDBM50612085(CHEMBL5269879)
Affinity DataKi:  3.60E+6nMAssay Description:Inhibition of human recombinant VHR expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate by stopped-flow ...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM16315(6-[(5-chloro-3-methyl-1-benzofuran-2-)sulfonyl]-2,...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant Aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50122956(CHEMBL138065 | [2,4-Bis-(4-methoxy-benzoyl)-pyrrol...)
Affinity DataIC50:  2.36nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50122956(CHEMBL138065 | [2,4-Bis-(4-methoxy-benzoyl)-pyrrol...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assa...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM16452((4-oxo-3-{[5-(trifluoromethyl)-1,3-benzothiazol-2-...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
LigandPNGBDBM50612104(CHEMBL5290902)
Affinity DataIC50:  5nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50612109(CHEMBL5275241)
Affinity DataIC50:  5nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50142318(CHEMBL428651 | {[2-Chloro-4-(3-oxo-2,3-diphenyl-pr...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
LigandPNGBDBM50142317((2-bromo-4-(3-oxo-2,3-diphenylpropyl)phenyl)difluo...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM50612073(CHEMBL5286261)
Affinity DataIC50:  6nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli by Coomassie reagent assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50612064(CHEMBL5285288)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
LigandPNGBDBM50142311(CHEMBL266056 | [(4-{2-[4-(Difluoro-phosphono-methy...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetAldo-keto reductase family 1 member B1(Homo sapiens (Human))TBA
LigandPNGBDBM50049730(2-(5-(2-methyl-3-phenylallylidene)-4-oxo-2-thioxot...)
Affinity DataIC50:  10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM6309(6-Acetyl-8-cyclopentyl-5-methyl-2-(5-piperazin-1-y...)
Affinity DataIC50:  11nMAssay Description:Inhibition of CDK4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

LigandPNGBDBM50612102(CHEMBL5273366)
Affinity DataIC50:  13nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCathepsin G(Homo sapiens (Human))
Aristotle University Of Thessaloniki

Curated by ChEMBL
LigandPNGBDBM50329819((R)-1-((2S,3R)-3-hydroxy-2-(6-phenylpicolinamido)b...)
Affinity DataIC50:  13.7nMAssay Description:Inhibition of cathepsin GMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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