TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
Affinity DataKi: 0.920nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.10nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 6.90nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 22nMAssay Description:Inhibition of human PTP1B expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Mi...More data for this Ligand-Target Pair
Affinity DataKi: 25nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 30nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 36nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
Affinity DataKi: 40nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrate incubated for 15 min by Michaelis-Menten analysisMore data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 62nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
Affinity DataKi: 107nMAssay Description:Inhibition of human ALR2 expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using D,L-glyceraldehyde as substrate in presence o...More data for this Ligand-Target Pair
Ligand InfoPDB
TargetInduced myeloid leukemia cell differentiation protein Mcl-1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 180nMAssay Description:Binding affinity to MCL1More data for this Ligand-Target Pair
Affinity DataKi: 250nMAssay Description:Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 270nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 290nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
TargetApoptosis regulator Bcl-2(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 320nMAssay Description:Binding affinity to BCl2More data for this Ligand-Target Pair
TargetBcl-2-like protein 1(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataKi: 480nMAssay Description:Binding affinity to Bcl-xlMore data for this Ligand-Target Pair
Affinity DataKi: 600nMAssay Description:Inhibition of PTP1B (1 to 321 residues) (unknown origin) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrate i...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 930nMAssay Description:Inhibition of human recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as subs...More data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataKi: 1.20E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+3nMAssay Description:Inhibition of human ALR2 assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 2.50E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 5.00E+3nMAssay Description:Inhibition of rat recombinant PTP1B (1 to 321 residues) expressed in Escherichia coli BL21 assessed as inhibition constant using pNPP as substrateMore data for this Ligand-Target Pair
Affinity DataKi: 8.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 3.70E+4nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 1.00E+5nMAssay Description:Inhibition of rat recombinant LAR expressed in Escherichia coli assessed as inhibition constant using pNPP as substrate incubated for 5 mins by liqui...More data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 1.20E+5nMAssay Description:Inhibition of human PTPalpha assessed as inhibition constantMore data for this Ligand-Target Pair
Ligand Info
Affinity DataKi: 1.80E+5nMAssay Description:Inhibition of PTPalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 4.50E+5nMAssay Description:Inhibition of LAR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+6nMAssay Description:Inhibition of LAR (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 2.00E+6nMAssay Description:Inhibition of PTPalpha (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
Affinity DataKi: 3.60E+6nMAssay Description:Inhibition of human recombinant VHR expressed in Escherichia coli BL21 (DE3) assessed as inhibition constant using pNPP as substrate by stopped-flow ...More data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 1nMAssay Description:Inhibition of human recombinant Aldose reductaseMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 2.36nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
TargetAldo-keto reductase family 1 member B1(Rattus norvegicus)
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 2.40nMAssay Description:Inhibition of ALR in Fischer-344 rat lens using D,L-glyceraldehyde as substrate in presence of NADPH measured after 3 mins by spectrophotometric assa...More data for this Ligand-Target Pair
Affinity DataIC50: 3.10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
Affinity DataIC50: 5nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 5nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrateMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human recombinant ALR2 expressed in Escherichia coli by Coomassie reagent assayMore data for this Ligand-Target Pair
Ligand Info
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 6nMAssay Description:Inhibition of human PTP1B (1 to 321 residues) expressed in Escherichia coli using FDP as substrateMore data for this Ligand-Target Pair
Affinity DataIC50: 10nMAssay Description:Inhibitory activity against aldose reductase enzymeMore data for this Ligand-Target Pair
TargetCyclin-dependent kinase 4(Homo sapiens (Human))
Aristotle University Of Thessaloniki
Curated by ChEMBL
Aristotle University Of Thessaloniki
Curated by ChEMBL
Affinity DataIC50: 13nMAssay Description:Inhibition of human PTP1B (1 to 298 residues) expressed in Escherichia coli using FDP as substrate by microplate readerMore data for this Ligand-Target Pair
Target InfoPDBMMDBNCI pathwayReactome pathwayKEGG
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
UniProtKB/SwissProt
B.MOADDrugBankantibodypediaGoogleScholar
Ligand Info
Affinity DataIC50: 13.7nMAssay Description:Inhibition of cathepsin GMore data for this Ligand-Target Pair