BDBM13990 5-{2-fluoro-5-[(1E)-3-[3-hydroxy-2-(methoxycarbonyl)phenoxy]prop-1-en-1-yl]phenyl}-1,2-oxazole-3-carboxylic acid::CHEMBL117869::Isoxazole carboxylic acid analog 1
SMILES COC(=O)c1c(O)cccc1OC\C=C\c1ccc(F)c(c1)-c1cc(no1)C(O)=O
InChI Key InChIKey=QKHWJUMLYAYZFS-ONEGZZNKSA-N
Activity Spreadsheet -- Enzyme Inhibition Constant Data from BindingDB
Found 16 hits for monomerid = 13990
Affinity DataKi: 6.90nMAssay Description:Inhibition of PTP1B (unknown origin) assessed as inhibition constantMore data for this Ligand-Target Pair
3D Structure (crystal)Affinity DataKi: 6.31E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1 [1-298](Homo sapiens (Human))
Abbott Laboratories
Abbott Laboratories
Affinity DataKi: 6.90E+3nM ΔG°: -6.97kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
Affinity DataKi: 6.90E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 6.90E+3nMAssay Description:Inhibition of human recombinant PTP1B expressed in Escherichia coli using para-nitrophenyl phosphate as substrate preincubated for 30 mins followed b...More data for this Ligand-Target Pair
Affinity DataKi: 6.90E+3nMAssay Description:Binding affinity for Protein-tyrosine phosphatase 1BMore data for this Ligand-Target Pair
Affinity DataKi: 6.90E+3nMAssay Description:Inhibition of PTP1BMore data for this Ligand-Target Pair
Affinity DataKi: 6.92E+3nMAssay Description:Inhibition of PTP1B (unknown origin)More data for this Ligand-Target Pair
Affinity DataKi: 7.00E+3nMAssay Description:Inhibition of PTP1B (unknown origin) using pNPP as substrate measured every 30 secs for 15 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Advinus Therapeutics
Curated by ChEMBL
Advinus Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.64E+5nMAssay Description:Inhibition of TCPTPMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Advinus Therapeutics
Curated by ChEMBL
Advinus Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.64E+5nMAssay Description:Inhibitory activity of the compound was determined against T cell protein tyrosine phosphatase (TCPTP)More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Advinus Therapeutics
Curated by ChEMBL
Advinus Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.64E+5nM ΔG°: -5.11kcal/molepH: 7.5 T: 2°CAssay Description:The phosphatase activity resulted in the formation of the colored product p-nitrophenol, which was continuously monitored at 405 nm every 30 s for 15...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Advinus Therapeutics
Curated by ChEMBL
Advinus Therapeutics
Curated by ChEMBL
Affinity DataKi: 1.64E+5nMAssay Description:Inhibition of TCPTPMore data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Advinus Therapeutics
Curated by ChEMBL
Advinus Therapeutics
Curated by ChEMBL
Affinity DataIC50: 1.64E+5nMAssay Description:Inhibition of TCPTP (unknown origin)More data for this Ligand-Target Pair
Affinity DataIC50: 6.90E+3nMAssay Description:Inhibition of human PTP1B (1 to 288 residues) expressed in Escherichia coli BL21 (DE3) cells using p-nitrophenyl phosphate as substrate monitered eve...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10E+5nMAssay Description:Inhibition of PTP1B expressed in Sf9 cellsMore data for this Ligand-Target Pair