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4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268510(CHEMBL495624 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

Ki: 40nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50487150(BUT-3-YNYL DIPHOSPHATE)

Ki: 60nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair

KEGG PC cid PC sid PDB

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268511(CHEMBL497634 | N-[3-(3-(4-Chlorophenoxy)phenyl)pro...)

Ki: 70nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
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4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268512(3-(3-Phenoxyphenyl)propylphosphinylmethylphosphoni...)

Ki: 220nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268627(CHEMBL496801 | N-Hydroxy-2-phosphono-5-(3-phenoxyp...)

Ki: 300nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268563(CHEMBL497617 | N-Hydroxy-N-[3-(3-phenoxyphenyl)pro...)

Ki: 320nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268562(CHEMBL497616 | N-Hydroxy-N-[3-(3-(3,4-dichlorophen...)

UniProtKB/SwissProt
GoogleScholar

4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Pseudomonas aeruginosa)
University of Illinois

BDBM228817(IspH inhibitor, 8)

Ki: 500nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair

PC cid PC sid

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268625(CHEMBL447414 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

Ki: 520nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268510(CHEMBL495624 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

Ki: 530nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM228818(8-Amino-3-benzyl-2,3,4,4 a-tetrahydro-1,2'H,6H...)

Ki: 700nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268509(CHEMBL495623 | N-[3-(3-(3,4-Dichlorophenoxy)phenyl...)

Ki: 740nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268564(CHEMBL497815 | N-[3-(4-Biphenyl)propyl]phosphonoac...)

Ki: 810nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268565(CHEMBL497410 | N-[3-(3-Phenoxyphenyl)propyl]sulfoa...)

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268566(CHEMBL497618 | N-Methyl-N-[3-(3-phenoxyphenyl)prop...)

Ki: 910nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268625(CHEMBL447414 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

Ki: 960nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268566(CHEMBL497618 | N-Methyl-N-[3-(3-phenoxyphenyl)prop...)

Ki: 1.00E+3nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268511(CHEMBL497634 | N-[3-(3-(4-Chlorophenoxy)phenyl)pro...)

Ki: 1.10E+3nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Aquifex aeolicus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50487149(PYRIDIN-3-YL-ETHYL-DIPHOSPHATE)

Ki: 1.20E+3nMAssay Description:Inhibition of Aquifex aeolicus IspH expressed in Escherichia coli BL21 (DE3) using HMBPP substrateMore data for this Ligand-Target Pair

KEGG PC cid PC sid

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268626(CHEMBL524084 | N-[2-(3-Phenoxyphenyl)ethyl]phospho...)

Ki: 1.50E+3nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268562(CHEMBL497616 | N-Hydroxy-N-[3-(3-(3,4-dichlorophen...)

Ki: 1.60E+3nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

4-hydroxy-3-methylbut-2-enyl diphosphate reductase(Escherichia coli (Enterobacteria))
University of Illinois

BDBM228818(8-Amino-3-benzyl-2,3,4,4 a-tetrahydro-1,2'H,6H...)

Ki: 3.00E+3nMAssay Description:In order to find new inhibitors, we carried out in silico screening of AaIspH and EcIspH using ZINC and National Cancer Institute (NCI) libraries and...More data for this Ligand-Target Pair

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PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Geranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL

BDBM50336506(2-(decyl(methyl)amino)ethane-1,1-diyldiphosphonic ...)

Ki: 3.30E+3nMAssay Description:Inhibition of human GGPPSChecked by AuthorMore data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268627(CHEMBL496801 | N-Hydroxy-2-phosphono-5-(3-phenoxyp...)

Ki: 4.10E+3nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268628(CHEMBL496802 | N-[4-(3-Phenoxyphenyl)butyl]phospho...)

Ki: 5.30E+3nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268629(3-(3-Phenoxyphenyl)propyl Phosphonoacetate Dipotas...)

Ki: 5.70E+3nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268626(CHEMBL524084 | N-[2-(3-Phenoxyphenyl)ethyl]phospho...)

Ki: 6.20E+3nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Geranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL

BDBM25259(3-(decyloxy)-1-(2-hydrogen phosphonato-2-phosphono...)

Ki: 6.90E+3nMAssay Description:Inhibition of human GGPPSChecked by AuthorMore data for this Ligand-Target Pair

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PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268676(2-Oxo-6-(4-phenoxyphenyl)hexylphosphonic Acid Dipo...)

Ki: >7.00E+3nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268677(CHEMBL498628 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268678(CHEMBL525377 | N-Hydroxy-N-[3-(4-methylbiphenyl)pr...)

PDB MMDB
UniProtKB/SwissProt
B.MOAD DrugBank GoogleScholar

4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268679(CHEMBL523897 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Geranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL

BDBM50336505(2-(methyl(octyl)amino)ethane-1,1-diyldiphosphonic ...)

Ki: 1.20E+4nMAssay Description:Inhibition of human GGPPSChecked by AuthorMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268676(2-Oxo-6-(4-phenoxyphenyl)hexylphosphonic Acid Dipo...)

Ki: 2.00E+4nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268564(CHEMBL497815 | N-[3-(4-Biphenyl)propyl]phosphonoac...)

Ki: >3.00E+4nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268565(CHEMBL497410 | N-[3-(3-Phenoxyphenyl)propyl]sulfoa...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268628(CHEMBL496802 | N-[4-(3-Phenoxyphenyl)butyl]phospho...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268677(CHEMBL498628 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268678(CHEMBL525377 | N-Hydroxy-N-[3-(4-methylbiphenyl)pr...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268679(CHEMBL523897 | N-[3-(3-Phenoxyphenyl)propyl]phosph...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268563(CHEMBL497617 | N-Hydroxy-N-[3-(3-phenoxyphenyl)pro...)

Ki: 3.00E+4nMAssay Description:Inhibition of human recombinant squalene synthase expressed in Escherichia coli cells assessed as conversion of [3H]FPP to squalene by liquid scintil...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268512(3-(3-Phenoxyphenyl)propylphosphinylmethylphosphoni...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD antibodypedia GoogleScholar

Squalene synthase(Homo sapiens (Human))
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268629(3-(3-Phenoxyphenyl)propyl Phosphonoacetate Dipotas...)

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Geranylgeranyl pyrophosphate synthase(Homo sapiens (Human))
National Institute Of Immunology

Curated by ChEMBL

BDBM12576(Bisphosphonate 1 | CHEMBL923 | JMC515594 Compound ...)

Ki: 8.30E+6nMAssay Description:Inhibition of human GGPPSChecked by AuthorMore data for this Ligand-Target Pair

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PDB MMDB
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4,4'-diapophytoene synthase(Staphylococcus aureus)
University Of Illinois At Urbana-Champaign

Curated by ChEMBL

BDBM50268680(CHEMBL495807 | N-3-(3-phenoxyphenyl)propylphosphon...)

IC50: 8nMAssay Description:Inhibition of Staphylococcus aureus histidine tagged dehydrosqualene synthase expressed in Escherichia coli BL21 (DE3) cells by continuous spectropho...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Farnesyl pyrophosphate synthase(Homo sapiens (Human))
Prenylx Research Institute

Curated by ChEMBL

BDBM50428292(CHEMBL2338356)

IC50: 30nMAssay Description:Inhibition of His6-tagged human truncated FPPS (6-353) expressed in Escherichia coli BL21(DE3) cells using geranyl diphosphate and isopentenyl diphos...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Farnesyl pyrophosphate synthase(Homo sapiens (Human))
Prenylx Research Institute

Curated by ChEMBL

BDBM50428292(CHEMBL2338356)

IC50: 30nMAssay Description:Binding affinity to human FPPS at 1 mM by X-ray crystallographic analysisMore data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Farnesyl pyrophosphate synthase(Homo sapiens (Human))
Prenylx Research Institute

Curated by ChEMBL

BDBM50428291(CHEMBL2338355)

IC50: 34nMAssay Description:Inhibition of His6-tagged human truncated FPPS (6-353) expressed in Escherichia coli BL21(DE3) cells using geranyl diphosphate and isopentenyl diphos...More data for this Ligand-Target Pair

PDB MMDB Reactome pathway KEGG
UniProtKB/SwissProt
B.MOAD DrugBank antibodypedia GoogleScholar

Farnesyl pyrophosphate synthase(Homo sapiens (Human))
Prenylx Research Institute

Curated by ChEMBL

BDBM50428296(CHEMBL2338360)

IC50: 36nMAssay Description:Inhibition of His6-tagged human truncated FPPS (6-353) expressed in Escherichia coli BL21(DE3) cells using geranyl diphosphate and isopentenyl diphos...More data for this Ligand-Target Pair