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Found 299 with Last Name = 'ohta' and Initial = 'k'
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  3.75E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  7.84E+3nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  1.12E+4nMAssay Description:Inhibition constant against DNA polymerase alpha non competitively on dNTP substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153111(CHEMBL189667 | [(3S,5S,10S,13R,17R)-17-((R)-1,5-Di...)
Affinity DataKi:  1.38E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153106(CHEMBL189703 | [(3S,10R,13R,17R)-17-((R)-1,5-Dimet...)
Affinity DataKi:  1.85E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetDNA polymerase alpha catalytic subunit(Homo sapiens (Human))
Frontier Research Center For Genome & Drug Discovery

Curated by ChEMBL
LigandPNGBDBM50153113(CHEMBL364611 | [(3S,10R,13R,17R)-17-((E)-(1R,4S)-4...)
Affinity DataKi:  2.79E+4nMAssay Description:Inhibition constant against DNA polymerase alpha competitively on DNA templateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074846(CHEMBL545597 | [3-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074867((2-{4-Methoxy-3-[2-(4-methoxy-phenyl)-ethoxy]-phen...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074866((2-{3-[2-(4-Fluoro-phenyl)-ethoxy]-4-methoxy-pheny...)
Affinity DataIC50:  1nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50170660(CHEMBL190883 | CHEMBL521582 | N,N-dipropyl-2-[4-me...)
Affinity DataIC50:  1.30nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074859((2-{3-[2-(3-Chloro-phenyl)-ethoxy]-4-methoxy-pheny...)
Affinity DataIC50:  1.5nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081380(CHEMBL553962 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  1.5nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074828(CHEMBL11290 | {2-[3-Methoxy-2-(3-phenyl-propoxy)-p...)
Affinity DataIC50:  1.70nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074827(CHEMBL542298 | Hexyl-[2-(4-methoxy-3-phenethyloxy-...)
Affinity DataIC50:  1.80nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081366(CHEMBL540331 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  1.80nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081369(CHEMBL128860 | CHEMBL541091 | [1-(4-Methoxy-3-phen...)
Affinity DataIC50:  2.10nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074839(CHEMBL542047 | [2-(3-Methoxy-2-phenethyloxy-phenyl...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074865(CHEMBL542295 | [2-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074869(4-(2-Dipropylamino-ethyl)-2-phenethyloxy-phenol; h...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetEstrogen receptor beta(Homo sapiens (Human))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  4nMAssay Description:Binding affinity to human recombinant ERbeta receptor by liquid scintillation counterMore data for this Ligand-Target Pair
TargetEstrogen receptor(Homo sapiens (Human))
Tohoku Pharmaceutical University

Curated by ChEMBL
LigandPNGBDBM17292((1S,10R,11S,14S,15S)-15-methyltetracyclo[8.7.0.0^{...)
Affinity DataIC50:  4nMAssay Description:Binding affinity to human recombinant ERalpha receptor by liquid scintillation counterMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081371(CHEMBL128799 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  4.5nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074853(CHEMBL11182 | {2-[4-Methoxy-3-(3-phenyl-propoxy)-p...)
Affinity DataIC50:  4.70nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50001955((-)6-Methyl-5,6,6a,7-tetrahydro-4H-dibenzo[de,g]qu...)
Affinity DataIC50:  5.10nMAssay Description:Inhibitory concentration against radioligand [3H](-)-sulpiride binding to Dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081375(CHEMBL128717 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  5.70nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074826(CHEMBL11774 | [2-(4-Methoxy-2-phenethyloxy-phenyl)...)
Affinity DataIC50:  6.60nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074840(CHEMBL11474 | [2-(2-Methoxy-4-phenethyloxy-phenyl)...)
Affinity DataIC50:  6.80nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074856(CHEMBL537251 | [2-(5-Methoxy-2-phenethyloxy-phenyl...)
Affinity DataIC50:  7.10nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074850(CHEMBL11803 | [2-(5-Chloro-2-phenethyloxy-phenyl)-...)
Affinity DataIC50:  7.20nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081372(CHEMBL127899 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  8nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081367(CHEMBL339638 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  9nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074873(CHEMBL542049 | {2-[4-Methoxy-3-(2-thiophen-2-yl-et...)
Affinity DataIC50:  9.40nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081376(CHEMBL341003 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  9.5nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081383(CHEMBL545760 | [2-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  10nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074844(CHEMBL11279 | [2-(5-Bromo-2-phenethyloxy-phenyl)-e...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074872(1-[2-(4-Methoxy-3-phenethyloxy-phenyl)-ethyl]-4-(2...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against radioligand [3H](-)-sulpiride binding to Dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074880(CHEMBL269638 | [3-(5-Bromo-2-phenethyloxy-phenyl)-...)
Affinity DataIC50:  11nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081393(CHEMBL127720 | [2-(4-Methoxy-3-phenethyloxy-phenyl...)
Affinity DataIC50:  12nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074830(CHEMBL11894 | [2-(3-Methoxy-4-phenethyloxy-phenyl)...)
Affinity DataIC50:  12nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074831(CHEMBL543015 | [2-(5-Fluoro-2-phenethyloxy-phenyl)...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074879(CHEMBL275948 | [3-(3-Methoxy-2-phenethyloxy-phenyl...)
Affinity DataIC50:  13nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50081373(CHEMBL421446 | [1-(4-Methoxy-3-phenethyloxy-benzyl...)
Affinity DataIC50:  13nMAssay Description:In vitro binding affinity at Sigma opioid receptors on guinea pig brain membranes by [3H]3-PPP displacement.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074838(CHEMBL276007 | [2-(2-Phenethyloxy-phenyl)-ethyl]-d...)
Affinity DataIC50:  15nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Rattus norvegicus (rat))
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074871(1-[3-(5-Chloro-2-phenethyloxy-phenyl)-propyl]-4-(2...)
Affinity DataIC50:  16nMAssay Description:Inhibitory concentration against radioligand [3H](-)-sulpiride binding to Dopamine receptor D2 in ratMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074851(CHEMBL542048 | [2-(4-Chloro-2-phenethyloxy-phenyl)...)
Affinity DataIC50:  18nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074854(3-{[2-(4-Methoxy-3-phenethyloxy-phenyl)-ethyl]-pro...)
Affinity DataIC50:  19nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrin alpha-4(Homo sapiens (Human))
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50231424((S)-3-(4-(4-(2,6-dicyanophenyl)piperazin-1-yl)phen...)
Affinity DataIC50:  19nMAssay Description:Displacement of VCAM1 from human VLA4 in Jurkat cells by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074842(CHEMBL11535 | [2-(3-Fluoro-2-phenethyloxy-phenyl)-...)
Affinity DataIC50:  22nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(RAT)
Taisho Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50074835(5-(2-Dipropylamino-ethyl)-2-phenethyloxy-phenol; h...)
Affinity DataIC50:  25nMAssay Description:Inhibitory concentration against radioligand [3H]3-PPP binding to Sigma opioid receptor type 1 in rat brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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