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Found 1651 with Last Name = 'ono' and Initial = 'e'
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22542(4-(1H-imidazol-4-ylmethyl)piperidine | 4-(1H-imida...)
Affinity DataKi:  0.501nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22916(5-{3-[(4-iodophenyl)methoxy]propyl}-1H-imidazole |...)
Affinity DataKi:  0.631nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50449917(BMS-180560 | CHEMBL2021417)
Affinity DataKi:  0.800nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419448(CHEMBL1923026)
Affinity DataKi:  1.02nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419444(CHEMBL43934 | VUF-5228)
Affinity DataKi:  1.05nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419456(CHEMBL1923034)
Affinity DataKi:  1.15nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50003019(8-(Hexahydro-2,5-methano-pentalen-3a-yl)-1,3-dipro...)
Affinity DataKi:  1.30nMAssay Description:Binding affinity towards adenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Rattus norvegicus (rat))
Griffin Discoveries

Curated by ChEMBL
LigandPNGBDBM50361015(CHEMBL592379)
Affinity DataKi:  1.55nMAssay Description:Binding affinity to rat histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414391(CHEMBL1202332 | CHEMBL553423)
Affinity DataKi:  1.58nMAssay Description:Agonistic activity at histamine H4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414391(CHEMBL1202332 | CHEMBL553423)
Affinity DataKi:  1.58nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  1.58nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  1.58nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419455(CHEMBL1923033)
Affinity DataKi:  1.62nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50282324(2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  2.10nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22912(VUF 8328 | VUF8328 | {[3-(1H-imidazol-4-yl)propyl]...)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414387(CHEMBL1743881)
Affinity DataKi:  2.51nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50003021(7-Ethyl-2-(hexahydro-2,5-methano-pentalen-3a-yl)-4...)
Affinity DataKi:  2.70nMAssay Description:Binding affinity towards Adenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  2.82nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50049201(2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  2.90nMAssay Description:Receptor binding affinity determined from competitive binding assay using 1251 labelled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50049201(2-Cyclopropyl-3-[2'-(1H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  2.90nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50003024((8-(dicyclopropylmethyl)-1,3-dipropylxanthine)8-Di...)
Affinity DataKi:  3nMAssay Description:Binding affinity towards adenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414388(CHEMBL1202321)
Affinity DataKi:  3.16nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22541(Clobenpropit | N''-[(4-chlorophenyl)methyl]{[3-(1H...)
Affinity DataKi:  3.16nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50282318(2-Methyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy...)
Affinity DataKi:  3.20nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282322(2-Propyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy...)
Affinity DataKi:  3.40nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50415482(CHEMBL591011)
Affinity DataKi:  4.27nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50415489(CHEMBL591969)
Affinity DataKi:  4.47nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50449914(CHEMBL2079784)
Affinity DataKi:  4.5nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50282316(2-Cyclopropyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-...)
Affinity DataKi:  4.60nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419454(CHEMBL1923032)
Affinity DataKi:  4.68nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50419449(CHEMBL1923027)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50361015(CHEMBL592379)
Affinity DataKi:  4.90nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414390(CHEMBL1202328)
Affinity DataKi:  5.01nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50415486(CHEMBL592663)
Affinity DataKi:  5.37nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM50003023(7-Ethyl-2-(hexahydro-2,5-methano-pentalen-3a-yl)-4...)
Affinity DataKi:  5.70nMAssay Description:Binding affinity towardsAdenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50415494(CHEMBL592434)
Affinity DataKi:  5.75nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50282315(2-Ethyl-3-[2'-(2H-tetrazol-5-yl)-biphenyl-4-yloxy]...)
Affinity DataKi:  5.90nMAssay Description:Inhibition of [125I]Sar1,Ile8 angiotensin II binding to Angiotensin II receptor type 1 in rat adrenocortical membraneMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50449919(CHEMBL2021415)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
LigandPNGBDBM50366331(CHEMBL1790055)
Affinity DataKi:  6.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414392(CHEMBL1202329)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414391(CHEMBL1202332 | CHEMBL553423)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]histamine from human H4 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM7966(2-(1H-imidazol-4-yl)ethan-1-amine | CHEMBL544208 |...)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]histamine from human H3 receptor expressed in HEK293 cells after 1 to 1.5 hrs by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM22911(2-(3H-imidazol-4-yl)ethylsulfanylmethanimidamide |...)
Affinity DataKi:  6.31nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
TargetAdenosine receptor A1(GUINEA PIG)
Kyowa Hakko Kogyo

Curated by ChEMBL
LigandPNGBDBM21173(1,3-dipropyl-8-cyclopentylxanthine | 8-cyclopentyl...)
Affinity DataKi:  6.40nMAssay Description:Binding affinity towards adenosine A1 receptor using N6-[3H]-cyclohexyladenosine in guinea pig forebrain membranesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50449910(CHEMBL2079782)
Affinity DataKi:  7.30nMAssay Description:Binding affinity for Angiotensin II receptor, type 1 determined using [125I]- labeled [Sar1,Ile8] angiotensin II in rat adrenocortical membranesMore data for this Ligand-Target Pair
In DepthDetails Article
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50412494(CHEMBL452847 | VUF-10497)
Affinity DataKi:  7.59nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H4 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50415480(CHEMBL591500)
Affinity DataKi:  7.59nMAssay Description:Displacement of [3H]histamine from human histamine H4 receptor expressed in HEK293T cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414389(CHEMBL1202324)
Affinity DataKi:  7.94nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Homo sapiens (Human))
Vu University Amsterdam

Curated by ChEMBL
LigandPNGBDBM50414376(CHEMBL561250)
Affinity DataKi:  7.94nMAssay Description:Displacement of [3H]N-alpha-methylhistamine from human histamine H3 receptor expressed in human SK-N-MC cells by liquid scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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