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Found 267 with Last Name = 'orsale' and Initial = 'mv'
TargetHistone deacetylase 1(Homo sapiens (Human))
Irbm Science Park

Curated by ChEMBL
LigandPNGBDBM50175036(CHEMBL3809599)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of recombinant human His-tagged HDAC1 expressed in insect cells preincubated for 10 mins followed by addition of FLUOR DE LYS as fluoresce...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316229(2-(1,2,3,4-tetrahydroisoquinolin-6-yl)-2H-indazole...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316242(2-(4-(piperidin-1-ylmethyl)phenyl)-2H-indazole-7-c...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 2(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PARP2 by trichloroacetic acid precipitation assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316237(2-(4-{[(2-Fluoroethyl)amino]methyl}phenyl)-2H-inda...)
Affinity DataIC50:  2.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316230(2-(1,2,3,4-tetrahydroisoquinolin-7-yl)-2H-indazole...)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316225((R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316228(2-(4-(pyrrolidin-2-yl)phenyl)-2H-indazole-7-carbox...)
Affinity DataIC50:  3.10nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316226((S)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316225((R)-2-(4-(piperidin-3-yl)phenyl)-2H-indazole-7-car...)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316234(2-(4-(1-(methylamino)ethyl)phenyl)-2H-indazole-7-c...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316244(2-(4-((dimethylamino)methyl)phenyl)-2H-indazole-7-...)
Affinity DataIC50:  3.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50306210(2-(4-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Affinity DataIC50:  3.80nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1807225 | CHEMBL1813106)
Affinity DataIC50:  4nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50480787(CHEMBL549592)
Affinity DataIC50:  4nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316238(2-{4-[(Ethylamino)methyl]phenyl}-2H-indazole-7-car...)
Affinity DataIC50:  4.30nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316243(2-[4-(Pyrrolidin-1-ylmethyl)phenyl]-2H-indazole-7-...)
Affinity DataIC50:  4.80nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1807225 | CHEMBL1813106)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350335(CHEMBL1813107)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316231(2-(3-((methylamino)methyl)phenyl)-2H-indazole-7-ca...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316239(2-(4-(((2-(dimethylamino)ethyl)(methyl)amino)methy...)
Affinity DataIC50:  5.90nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM22638(2-(4-acetyl-1-methylpiperazin-2-yl)-N-[(4-fluoroph...)
Affinity DataIC50:  6nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350339(CHEMBL1813111)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316235(2-(4-((isopropylamino)methyl)phenyl)-2H-indazole-7...)
Affinity DataIC50:  6.70nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50245989(1-(5-(3-((4-(1,3,4-oxadiazol-2-yl)phenoxy)methyl)-...)
Affinity DataIC50:  7nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350339(CHEMBL1813111)
Affinity DataIC50:  7nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350338(CHEMBL1813110)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316227(2-(4-(piperidin-4-yl)phenyl)-2H-indazole-7-carboxa...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350339(CHEMBL1813111)
Affinity DataIC50:  9nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349259(CHEMBL1807222 | CHEMBL1813105)
Affinity DataIC50:  12nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349259(CHEMBL1807222 | CHEMBL1813105)
Affinity DataIC50:  12nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350342(CHEMBL1813114)
Affinity DataIC50:  13nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50480771(CHEMBL563757)
Affinity DataIC50:  14nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316249(2-(3-Chlorophenyl)-2H-indazole-7-carboxamide | CHE...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316236(2-(4-{[(2,2-Difluoroethyl)amino]methyl}phenyl)-2H-...)
Affinity DataIC50:  14nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349262(CHEMBL1807225 | CHEMBL1813106)
Affinity DataIC50:  15nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50480773(CHEMBL564267)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50480773(CHEMBL564267)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349268(CHEMBL1807231 | CHEMBL1813109)
Affinity DataIC50:  15nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM25351(N-[2-(4-{[(4-fluorophenyl)methyl]carbamoyl}-5-hydr...)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50245986(2,2,2-trifluoro-1-(5-(3-(thiophen-2-ylmethyl)-1,2,...)
Affinity DataIC50:  15nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistone deacetylase 4(Homo sapiens (Human))
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50245988(4-((5-(5-(2,2,2-trifluoroacetyl)thiophen-2-yl)-1,2...)
Affinity DataIC50:  15nMAssay Description:Inhibition of His-tagged HDAC4 catalytic domain (unknown origin) expressed in Escherichia coliMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIntegrase(Human immunodeficiency virus 1)
Irbm-Merck Research Laboratories Rome

Curated by ChEMBL
LigandPNGBDBM50480773(CHEMBL564267)
Affinity DataIC50:  15nMAssay Description:Inhibition of recombinant HIV-1 integrase strand transfer activityMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350335(CHEMBL1813107)
Affinity DataIC50:  16nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316233(2-(4-(2-(methylamino)propan-2-yl)phenyl)-2H-indazo...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350342(CHEMBL1813114)
Affinity DataIC50:  17nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase 1(Homo sapiens (Human))
Irbm/Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50316241(2-[4-(Morpholin-4-ylmethyl)phenyl]-2H-indazole-7-c...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human PARP1 by SPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349268(CHEMBL1807231 | CHEMBL1813109)
Affinity DataIC50:  18nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 20% normal human serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50350338(CHEMBL1813110)
Affinity DataIC50:  18nMAssay Description:Displacement of BODIPY-cyclopamine from human Smo expressed in HEK293 cells in presence of 2% fetal calf serumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Homo sapiens (Human))
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50349268(CHEMBL1807231 | CHEMBL1813109)
Affinity DataIC50:  18nMAssay Description:Antagonist activity at smoothened expressed in mouse Shh Light2 cells assessed as inhibition of purmorphamine- induced Gli-dependent luciferase gene ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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