Compile Data Set for Download or QSAR
maximum 50k data
Found 100 with Last Name = 'ortiz' and Initial = 'ma'
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM2579((2S,3R,4R,6R)-3-methoxy-2-methyl-4-(methylamino)-2...)
Affinity DataIC50:  0.00200nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.100nMAssay Description:Inhibition of BLK (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BTK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of BMX (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of BMX (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of BLK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of BTK (unknown origin) using Blk/Lyntide as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs in pr...More data for this Ligand-Target Pair
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  4.90nMAssay Description:Inhibition of ITK (unknown origin) using Blk/Lyntide as substrate preincubated for 1 hr followed by substrate addition and measured after 2 hrs in pr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of EGFR (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assayMore data for this Ligand-Target Pair
TargetCytoplasmic tyrosine-protein kinase BMX(Homo sapiens (Human))TBA
LigandPNGBDBM50614536(CHEMBL5278149)
Affinity DataIC50:  5.70nMAssay Description:Inhibition of BMX (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50614536(CHEMBL5278149)
Affinity DataIC50:  13nMAssay Description:Inhibition of BTK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  29nMAssay Description:Inhibition of HCK (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  30nMAssay Description:Inhibition of HCK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  33nMAssay Description:Inhibition of JAK3 (unknown origin) incubated for 1 hr in presence of ATP by Z'LYTE assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  34nMAssay Description:Inhibition of SRC (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase Blk(Homo sapiens (Human))TBA
LigandPNGBDBM50614536(CHEMBL5278149)
Affinity DataIC50:  36nMAssay Description:Inhibition of BLK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50357312(IBRUTINIB | PCI-32765 | US10124003, Ref. Ex. Compo...)
Affinity DataIC50:  44nMAssay Description:Covalent inhibition of NanoLuc fused BTK (unknown origin) expressed in HEK293 cells incubated for 90 mins by NanoBRET assayMore data for this Ligand-Target Pair
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  109nMAssay Description:Covalent inhibition of NanoLuc fused BTK (unknown origin) expressed in HEK293 cells incubated for 90 mins by NanoBRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447840(BMS-204493 | CHEMBL472172)
Affinity DataIC50:  114nMAssay Description:Inverse agonist activity at RARalpha (unknown origin)More data for this Ligand-Target Pair
TargetEpidermal growth factor receptor(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  197nMAssay Description:Inhibition of EGFR (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50542351(CHEMBL4637017)
Affinity DataIC50:  210nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50542348(CHEMBL4647760)
Affinity DataIC50:  226nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50542350(CHEMBL4635320)
Affinity DataIC50:  308nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase BTK(Homo sapiens (Human))TBA
LigandPNGBDBM50614536(CHEMBL5278149)
Affinity DataIC50:  314nMAssay Description:Covalent inhibition of NanoLuc fused BTK (unknown origin) expressed in HEK293 cells incubated for 90 mins by NanoBRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50542349(CHEMBL4649625)
Affinity DataIC50:  318nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase ITK/TSK(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  344nMAssay Description:Inhibition of ITK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50542347(CHEMBL4638119)
Affinity DataIC50:  654nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))TBA
LigandPNGBDBM50614535(CHEMBL5271284)
Affinity DataIC50:  874nMAssay Description:Inhibition of JAK3 (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447837(CHEMBL3114297)
Affinity DataIC50:  1.28E+3nMAssay Description:Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as inhibition of ATRA-induced transcriptional activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50542346(CHEMBL4649046)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProto-oncogene tyrosine-protein kinase Src(Homo sapiens (Human))TBA
LigandPNGBDBM50614536(CHEMBL5278149)
Affinity DataIC50:  1.71E+3nMAssay Description:Inhibition of SRC (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetTyrosine-protein kinase HCK(Homo sapiens (Human))TBA
LigandPNGBDBM50614536(CHEMBL5278149)
Affinity DataIC50:  2.31E+3nMAssay Description:Inhibition of HCK (unknown origin) by Z'LYTE assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447838(CHEMBL3114296)
Affinity DataIC50:  2.65E+3nMAssay Description:Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as inhibition of ATRA-induced transcriptional activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM50299148((S)-1-(4-(5-cyclopropyl-1H-pyrazol-3-ylamino)pyrro...)
Affinity DataIC50:  3.16E+3nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447838(CHEMBL3114296)
Affinity DataIC50:  3.37E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447835(CHEMBL3114299)
Affinity DataIC50:  4.43E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRetinoic acid receptor alpha(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50244760((E)-4-{3-[3-Adamantan-1-yl-4-(2-methoxy-ethoxymeth...)
Affinity DataIC50:  4.47E+3nMAssay Description:Antagonist activity at Gal4-fused RARalpha (unknown origin) transfected in HEK293 cells assessed as inhibition of ATRA-induced transcriptional activi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase LMTK3(Homo sapiens)
San Diego State University

Curated by ChEMBL
LigandPNGBDBM158154(US10081622, Compound 11 | US10370379, Entrectinib ...)
Affinity DataIC50:  4.65E+3nMAssay Description:Inhibition of LMTK3 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447839(CHEMBL565088)
Affinity DataIC50:  4.75E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447837(CHEMBL3114297)
Affinity DataIC50:  4.78E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235609(CHEMBL4096280)
Affinity DataIC50:  5.10E+3nMAssay Description:Antagonist activity at mouse Gal4-fused DBD RORgamma LBD (Pro-261-end) expressed in TRex-CHOK1 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInhibitor of nuclear factor kappa-B kinase subunit beta(Homo sapiens (Human))
Universidade De Vigo

Curated by ChEMBL
LigandPNGBDBM50447836(CHEMBL3114298)
Affinity DataIC50:  5.16E+3nMAssay Description:Inhibition of recombinant IKKbeta (unknown origin) using ulight-IkappaomegaBalpha as substrate after 2 hrs by LANCE ultra TR-FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235608(CHEMBL4067306)
Affinity DataIC50:  5.60E+3nMAssay Description:Antagonist activity at mouse Gal4-fused DBD RORgamma LBD (Pro-261-end) expressed in TRex-CHOK1 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235604(CHEMBL4088559)
Affinity DataIC50:  5.80E+3nMAssay Description:Antagonist activity at mouse Gal4-fused DBD RORgamma LBD (Pro-261-end) expressed in TRex-CHOK1 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235602(CHEMBL4101440)
Affinity DataIC50:  5.80E+3nMAssay Description:Compound was tested for CETP inhibition by a precipitation method to separate lipoproteins after incubation of radiolabeled HDL with LDL and CETP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235608(CHEMBL4067306)
Affinity DataIC50:  6.00E+3nMAssay Description:Antagonist activity at human Gal4-fused DBD RORalpha LBD (Pro-211-end) expressed in TRex-CHOK1 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235607(CHEMBL4091903)
Affinity DataIC50:  6.30E+3nMAssay Description:Binding affinity against 5-hydroxytryptamine 3 receptor using [3H]BRL-43694 as radioligand in rat posterior cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235621(CHEMBL4071074)
Affinity DataIC50:  6.30E+3nMAssay Description:Antagonist activity at mouse Gal4-fused DBD RORgamma LBD (Pro-261-end) expressed in TRex-CHOK1 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-alpha(Homo sapiens (Human))
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235609(CHEMBL4096280)
Affinity DataIC50:  6.40E+3nMAssay Description:Antagonist activity at human Gal4-fused DBD RORalpha LBD (Pro-211-end) expressed in TRex-CHOK1 cells after 20 hrs by luciferase reporter gene assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNuclear receptor ROR-gamma(Mus musculus)
Torrey Pines Institute For Molecular Studies

Curated by ChEMBL
LigandPNGBDBM50235602(CHEMBL4101440)
Affinity DataIC50:  6.40E+3nMAssay Description:Compound was tested for CETP inhibition by a precipitation method to separate lipoproteins after incubation of radiolabeled HDL with LDL and CETP.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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