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Found 784 with Last Name = 'oste' and Initial = 'l'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Imperial College

Curated by PDSP Ki Database
LigandPNGBDBM50354849(CCI-18781 | Cutivate | FLUTICASONE PROPIONATE | Fl...)
Affinity DataKi:  0.238nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Imperial College

Curated by PDSP Ki Database
LigandPNGBDBM86696(des-CIC | desisobutyryl-ciclesonide)
Affinity DataKi:  0.310nMMore data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Imperial College

Curated by PDSP Ki Database
LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  6.70nMMore data for this Ligand-Target Pair
TargetEctonucleotide pyrophosphatase/phosphodiesterase family member 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50187686(CHEMBL3828074 | US10526329, Compound 2 | US1107261...)
Affinity DataKi:  15nMAssay Description:Competitive inhibition of human ATX using LPC (16:0) as substrate after 30 mins by Michaelis-Menten plot analysisMore data for this Ligand-Target Pair
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548385(Glpg-1205 | Glpg1205)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-9-(2-phenylethyl)-2-(2-pyrazin-2-yloxyethoxy)-6,7-dihydropyrimido[6,1-a]isoquinolin-4-one from recombinant FLAG-tagged GPR84 (un...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  5.00E+3nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  8.00E+3nM IC50:  1.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  9.00E+3nM IC50:  2.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  9.00E+3nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of NaMN substrate by malachite gre...More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  1.00E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318652((E)-4-(2-(anthracen-9-ylmethylene)hydrazinyl)-N-(3...)
Affinity DataKi:  1.00E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of ATP substrate by malachite gree...More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  1.80E+4nM IC50:  3.60E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  1.80E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of NaMN substrate by malachite gre...More data for this Ligand-Target Pair
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290175(4-ammonio-5-{[(2R,4S,6S)-4-hydroxy-6-(hydroxymethy...)
Affinity DataKi:  2.00E+4nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  2.10E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNicotinate-nucleotide adenylyltransferase(Escherichia coli)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  2.50E+4nM IC50:  6.50E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  3.20E+4nMAssay Description:The enzymatic assay was masured at fixed NaMN and ATP concentration (equal to two-fold km values)with various concentration of inhibitory compounds.More data for this Ligand-Target Pair
TargetProbable nicotinate-nucleotide adenylyltransferase(Bacillus anthracis)
Burnham Institute For Medical Research

LigandPNGBDBM50318653(3-amino-N-(3-fluorophenyl)-6-(thiophen-2-yl)thieno...)
Affinity DataKi:  3.20E+4nMAssay Description:Inhibition of Bacillus anthracis nicotinate-nucleotide adenylyltransferase preincubated for 5 mins before addition of ATP substrate by malachite gree...More data for this Ligand-Target Pair
TargetTyrosine--tRNA ligase, cytoplasmic(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM20461((6E)-N-[(4-hydroxy-3-methoxyphenyl)methyl]-8-methy...)
Affinity DataKi:  4.20E+4nMAssay Description:Compound was tested for the inhibition of aminoacyl tRNA SynthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50290174(4-ammonio-5-{[(2R,6S)-6-(hydroxymethyl)piperidin-2...)
Affinity DataKi:  2.30E+5nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403640(CHEMBL2115178)
Affinity DataKi:  3.80E+5nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50366478(CHEMBL609498)
Affinity DataKi:  5.00E+5nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetGlutamine--tRNA ligase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50403639(CHEMBL2114154)
Affinity DataKi:  1.14E+7nMAssay Description:Compound was tested for the inhibition of Escherichia coli glutamyl-t-RNA synthetaseMore data for this Ligand-Target Pair
In DepthDetails Article
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576247(CHEMBL4874736)
Affinity DataIC50:  0.0320nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359779(CHEMBL1928271)
Affinity DataIC50:  0.260nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576248(CHEMBL4864274)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576248(CHEMBL4864274)
Affinity DataIC50:  0.300nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359773(CHEMBL1928265)
Affinity DataIC50:  0.310nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576247(CHEMBL4874736)
Affinity DataIC50:  0.320nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576240(CHEMBL4877932)
Affinity DataIC50:  0.430nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576240(CHEMBL4877932)
Affinity DataIC50:  0.430nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetG-protein coupled receptor 84(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50548398(CHEMBL3718309)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at recombinant human GPR84 stably overexpressed in HEK293T cell membranes co-expressing G-alpha assessed as inhibition of DIM-sti...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Rattus norvegicus (Rat))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of rat NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576242(CHEMBL4850513)
Affinity DataIC50:  0.610nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576242(CHEMBL4850513)
Affinity DataIC50:  0.610nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359795(CHEMBL1928258)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359767(CHEMBL1928259)
Affinity DataIC50:  0.690nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359774(CHEMBL1928266)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359768(CHEMBL1928260)
Affinity DataIC50:  0.75nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576246(CHEMBL4847056)
Affinity DataIC50:  0.770nMAssay Description:Antagonist activity at recombinant human S1P2 receptor in HFL1 cells assessed as inhibition of EC80 S1P-induced IL8 release incubated for 16 to 24 hr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576246(CHEMBL4847056)
Affinity DataIC50:  0.770nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359777(CHEMBL1928269)
Affinity DataIC50:  0.780nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSphingosine 1-phosphate receptor 2(Homo sapiens (Human))
Galapagos

Curated by ChEMBL
LigandPNGBDBM50576234(CHEMBL4852127)
Affinity DataIC50:  0.800nMAssay Description:Antagonist activity at recombinant human S1P2 receptor expressed in human CHO cells assessed as EC80 S1P-induced activation incubated for 4 hrs in pr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetNeprilysin(Oryctolagus cuniculus (rabbit))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50197517((S)-2-{1-[3-(4-chloro-phenyl)-propylcarbamoyl]-cyc...)
Affinity DataIC50:  0.800nMAssay Description:Inhibition of rabbit NEPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359778(CHEMBL1928270)
Affinity DataIC50:  0.860nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
TBA

Curated by ChEMBL
LigandPNGBDBM591((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  0.900nMAssay Description:The compound was tested in vitro for its inhibitory activity against HIV-1 Proteinase activityMore data for this Ligand-Target Pair
In DepthDetails Article
TargetDimer of Gag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxo Group Research

LigandPNGBDBM591((2R,4S)-2-[(R)-(benzylcarbamoyl)(1-phenylacetamido...)
Affinity DataIC50:  0.900nMpH: 6.0 T: 2°CAssay Description:IC50 values were obtained by assaying the enzyme against the synthetic substrate peptide KQGTVSFNFPQIT, which was tritiated at the proline residue, a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359790(CHEMBL1928253)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359789(CHEMBL1928252)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50359771(CHEMBL1928263)
Affinity DataIC50:  1nMAssay Description:Inhibition of human PDE5 isolated from corpus cavernosum after 30 to 60 mins by scintillation counting methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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