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Found 1102 with Last Name = 'paone' and Initial = 'dv'
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362044(US10272077, Example 4 | US9833448, Example 4)
Affinity DataKi:  0.0150nMAssay Description:Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362044(US10272077, Example 4 | US9833448, Example 4)
Affinity DataKi:  0.0150nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320811((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...)
Affinity DataKi:  0.0160nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362171(US10272077, Example 5 | US9833448, Example 5)
Affinity DataKi:  0.0170nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320710((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3-fluorop...)
Affinity DataKi:  0.0170nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362171(US10272077, Example 5 | US9833448, Example 5)
Affinity DataKi:  0.0170nMAssay Description:Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320946((R)- or (S)-1- (Cyclopropyl(4-(1,1- difluoroethyl)...)
Affinity DataKi:  0.0200nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320813((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...)
Affinity DataKi:  0.0220nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320712((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-2-fluorop...)
Affinity DataKi:  0.0240nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320710((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3-fluorop...)
Affinity DataKi:  0.0250nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320811((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...)
Affinity DataKi:  0.0270nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320944((R)- or (S)-1-(1-(4- (difluoromethyl)-2- fluorophe...)
Affinity DataKi:  0.0300nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320813((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-3- fluorop...)
Affinity DataKi:  0.0300nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320801((R)- or (S)-l-(1-(4-(1,1- Difluoroethyl)phenyl)-2-...)
Affinity DataKi:  0.0300nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50342639(CHEMBL1770729 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0360nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320712((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-2-fluorop...)
Affinity DataKi:  0.0360nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320799((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)pro...)
Affinity DataKi:  0.0380nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50342638(CHEMBL1770728 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0390nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50342625(CHEMBL1770715 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0400nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320732((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)-2-...)
Affinity DataKi:  0.0400nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320726((R)- or (S)-6-(Dimethylamino)- 1-(1-(2-fluoro-4- (...)
Affinity DataKi:  0.0400nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320795((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Affinity DataKi:  0.0410nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320797((R)- or (S)-1-(Cyclopropyl(2-fluoro-4- (trifluorom...)
Affinity DataKi:  0.0420nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320801((R)- or (S)-l-(1-(4-(1,1- Difluoroethyl)phenyl)-2-...)
Affinity DataKi:  0.0430nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Affinity DataKi:  0.0440nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320817((R)- or (S)-6-(Dimethylamino)-1-(1-(3- fluoro-4-(t...)
Affinity DataKi:  0.0440nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320809((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-2- fluorop...)
Affinity DataKi:  0.0450nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320815((R)- or (S)-6-(Dimethylamino)-1-(1-(3- fluoro-4-(t...)
Affinity DataKi:  0.0460nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320770((R)- or (S)-6-(Dimethylamino)-3- (fluoromethyl)-1-...)
Affinity DataKi:  0.0470nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320728((R)- or (S)-1-(Cyclopropyl(2- fluoro-4- (trifluoro...)
Affinity DataKi:  0.0470nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320793((R)- or (S)-6-(Dimethylamino)-1-(1-(2- fluoro-4-(t...)
Affinity DataKi:  0.0480nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320789((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)phenyl)eth...)
Affinity DataKi:  0.0480nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320728((R)- or (S)-1-(Cyclopropyl(2- fluoro-4- (trifluoro...)
Affinity DataKi:  0.0500nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320809((R)- or (S)-1-(1-(4-(1,1-Difluoroethyl)-2- fluorop...)
Affinity DataKi:  0.0500nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320948((R)- or (S)-1- (Cyclopropyl(4-(1,1- difluoroethyl)...)
Affinity DataKi:  0.0500nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50342636(CHEMBL1770726 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM50342634(CHEMBL1770724 | N-((6S,9R)-6-(2,3-difluorophenyl)-...)
Affinity DataKi:  0.0500nMAssay Description:Displacement of [125I]-CGRP from human recombinant CGRP receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320807((R)- or (S)-1-(Cyclopropyl(4-(1,1- difluoroethyl)p...)
Affinity DataKi:  0.0530nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320670((R)- or (S)-6-(Dimethylamino)-3- (hydroxymethyl)-1...)
Affinity DataKi:  0.0540nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM381649(US10272077, Example 17)
Affinity DataKi:  0.0550nMAssay Description:The binding of 125I-CGRP to receptors in SK-N-MC cell membranes was carried out essentially as described (Edvinsson et al. (2001) Eur. J. Pharmacol. ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCalcitonin gene-related peptide type 1 receptor(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM362174(US9833448, Example 17)
Affinity DataKi:  0.0550nMAssay Description:Cells were resuspended in DMEM/F12 (Hyclone) supplemented with 1 g/L BSA and 300 μM isobutyl-methylxanthine. Cells were then plated in a 384-wel...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320706((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3- fluoro...)
Affinity DataKi:  0.0550nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320756(US10174037, Example 162 | US10174037, Example 163)
Affinity DataKi:  0.0560nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320706((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3- fluoro...)
Affinity DataKi:  0.0570nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320797((R)- or (S)-1-(Cyclopropyl(2-fluoro-4- (trifluorom...)
Affinity DataKi:  0.0580nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320770((R)- or (S)-6-(Dimethylamino)-3- (fluoromethyl)-1-...)
Affinity DataKi:  0.0580nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetcGMP-dependent 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320774((R)- or (S)-1-(Cyclopropyl(3-fluoro-4- (trifluorom...)
Affinity DataKi:  0.0580nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320726((R)- or (S)-6-(Dimethylamino)- 1-(1-(2-fluoro-4- (...)
Affinity DataKi:  0.0590nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320817((R)- or (S)-6-(Dimethylamino)-1-(1-(3- fluoro-4-(t...)
Affinity DataKi:  0.0630nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetPhosphodiesterase(Macaca mulatta (Rhesus macaque))
Merck Sharp & Dohme

US Patent
LigandPNGBDBM320710((R)- or (S)-1-(1-(4-(1,1- Difluoroethyl)-3-fluorop...)
Affinity DataKi:  0.0630nMAssay Description:Performed by Lab B. The activity of the compounds in accordance with the present invention as PDE2 inhibitors may be readily determined using a fluor...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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