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Found 1447 with Last Name = 'pevarello' and Initial = 'p'
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247250(US9447029, 1-1)
Affinity DataKi:  100nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247253(US9447029, 1-6)
Affinity DataKi:  100nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247254(US9447029, 1-7)
Affinity DataKi:  100nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247256(US9447029, 1-15)
Affinity DataKi:  200nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247257(US9447029, 1-18)
Affinity DataKi:  200nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247260(US9447029, 1-32)
Affinity DataKi:  300nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247255(US9447029, 1-14)
Affinity DataKi:  500nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247259(US9447029, 1-29)
Affinity DataKi:  700nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247264(US9447029, 4-1)
Affinity DataKi:  1.10E+3nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetVoltage-dependent N-type calcium channel subunit alpha-1B(Homo sapiens (Human))
Newron Pharmaceuticals

US Patent
LigandPNGBDBM247263(US9447029, 3-3)
Affinity DataKi:  1.70E+3nMAssay Description:Cells and methods: Functional inhibition of the sodium currents is studied using whole cell patch clamp methods (Hamill O. P., Marty A., Neher E., Sa...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7167(3-(4-sulfamoylphenyl)-3,4,10,11-tetraazatricyclo[7...)
Affinity DataIC50:  0.300nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31541(pyrazolo[4,3-h]quinazoline-3-carboxamide, 24)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307546(CHEMBL598401 | Ethyl 4-[(3-Carbamoyl-1-methyl-4,5-...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307543(1-Methyl-8-{[1-(methylsulfonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  1nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7177(3-(4-methanesulfonylphenyl)-3,4,10,11-tetraazatric...)
Affinity DataIC50:  1nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7214(3-(2,2,2-trifluoroethyl)-3,4,10,11-tetraazatricycl...)
Affinity DataIC50:  2nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31532(pyrazolo[4,3-h]quinazoline-3-carboxamide, 1)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM31539(pyrazolo[4,3-h]quinazoline-3-carboxamide, 22)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates, followed by quantitation of the phosphorylat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7107((2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(1-oxo...)
Affinity DataIC50:  2nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7169(3-[4-(methylsulfamoyl)phenyl]-3,4,10,11-tetraazatr...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7173(3-[4-(butylsulfamoyl)phenyl]-3,4,10,11-tetraazatri...)
Affinity DataIC50:  2nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307522(8-(Cyclopentylamino)-1-methyl-4,5-dihydro-1H-pyraz...)
Affinity DataIC50:  2nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7111((2S)-N-(5-Cyclopropyl-1H-pyrazol-3-yl)-2-[4-(2-oxo...)
Affinity DataIC50:  2nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7163(3-Phenylacetamidoaminopyrazole deriv. 40 | CS10 | ...)
Affinity DataIC50:  3nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  3nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7159(3-Phenylacetamidoaminopyrazole deriv. 36 | N-(5-Cy...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7162(3-Phenylacetamidoaminopyrazole deriv. 39 | 4 -{2-[...)
Affinity DataIC50:  4nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307520(8-(Cyclohexylamino)-1-methyl-4,5-dihydro-1H-pyrazo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307545(1-Methyl-8-{[1-(phenylsulfonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  4nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7166(3-(4-sulfamoylphenyl)-3,4,10,11-tetraazatricyclo[7...)
Affinity DataIC50:  4nMpH: 7.4 T: 2°CAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7195(3-(4-cyanophenyl)-3,4,10,11-tetraazatricyclo[7.3.0...)
Affinity DataIC50:  5nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307509(CHEMBL592272 | N-1-Dimethyl-8-{[1-(phenylsulfonyl)...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50378657(CHEMBL1230607)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK5/p25 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50027427(CHEMBL1744453)
Affinity DataIC50:  5nMAssay Description:Inhibition of human CDK2/cyclin A expressed in Escherichia coli BL21 by scintillation proximity assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307538(8-(Cyclopentylamino)-1-(4-sulfamoylphenyl)-4,5-dih...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307529(8-(Cyclopentylamino)-1-(2,2,2-trifluoroethyl)-4,5-...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  5nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 7(Homo sapiens (Human))
Axxam

US Patent
LigandPNGBDBM446067(2-chloro-6-fluoro-N-(2-{4-[(3-fluorophenyl)methoxy...)
Affinity DataIC50:  5.95nMAssay Description:In order to directly monitor the block of P2X7 channel, an electrophysiological assay was developed and implemented on the QPatch16X automated electr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCyclin-dependent kinase 5 activator 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK5/P25More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307553(8-(Cyclopentylamino)-1-(4-methoxyphenyl)-4,5-dihyd...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307506(1-Methyl-8-{[1-(phenylcarbonyl)piperidin-4-yl]amin...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307530(8-(Cyclopentylamino)-1-(1-methylpiperidin-4-yl)-4,...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase/G2/mitotic-specific cyclin- 1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  6nMAssay Description:Inhibition of CDK1/Cyclin BMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307535(8-[(1-Acetylpiperidin-4-yl)amino]-1-methyl-4,5-dih...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A1/Cyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307550(1-(1-Acetylpiperidin-4-yl)-8-(cyclopentylamino)-4,...)
Affinity DataIC50:  7nMAssay Description:Inhibition of CDK2/Cyclin AMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7187(3-(4-chlorophenyl)-3,4,10,11-tetraazatricyclo[7.3....)
Affinity DataIC50:  8nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCyclin-A2/Cyclin-dependent kinase 2(Homo sapiens (Human))
Nerviano Medical Sciences

LigandPNGBDBM7206(3-(pyridin-2-yl)-3,4,10,11-tetraazatricyclo[7.3.0....)
Affinity DataIC50:  8nMAssay Description:The biochemical activity of compounds was determined by incubation with specific enzymes and substrates in the presence ATP/[gamma-33P] ATP. After in...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCyclin-dependent kinase 2/G1/S-specific cyclin-E1(Homo sapiens (Human))
Nerviano Medical Sciences

Curated by ChEMBL
LigandPNGBDBM50307507(CHEMBL597754 | N-1-Dimethyl-8-{[1-(methylsulfonyl)...)
Affinity DataIC50:  8nMAssay Description:Inhibition of CDK2/Cyclin EMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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