TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 2.10E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PTP1B catalytic domain (1 to 393 residues) expressed in Escherichia coli strain Rosetta2 (DE3) using DiFMU...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 3.10E+3nMAssay Description:Inhibition of human SHP1 (245 to 521 residues) expressed in Escherichia coli strain BL21(DE3) using DiFMUP as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 4.10E+3nMAssay Description:Inhibition of human SHP2 (246 to 527 residues) expressed in Escherichia coli strain BL21(DE3) using DiFMUP as substrate preincubated for 10 mins foll...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 4.80E+3nMAssay Description:Inhibition of human N-terminal His6-tagged PTP1B catalytic domain (1 to 298 residues) expressed in Escherichia coli strain Rosetta2 (DE3) using DiFMU...More data for this Ligand-Target Pair
TargetPhosphatidylinositol 3,4,5-trisphosphate 3-phosphatase and dual-specificity protein phosphatase PTEN(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 1.33E+4nMAssay Description:Inhibition of human PTEN (1 to 403 residues) expressed in Escherichia coli strain BL21(DE3) using DiFMUP as substrate preincubated for 10 mins follow...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 1.88E+4nMAssay Description:Inhibition of human N-terminal His6-tagged TCPTP catalytic domain (1 to 336 residues) expressed in Escherichia coli strain Rosetta2 (DE3) using DiFMU...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 2.30E+4nMAssay Description:Inhibition of human N-terminal His6-tagged TCPTP catalytic domain (1 to 296 residues) expressed in Escherichia coli strain Rosetta2 (DE3) using DiFMU...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase eta(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 1.12E+5nMAssay Description:Inhibition of human PTPRJ (1019 to 1311 residues) expressed in Escherichia coli strain BL21(DE3) using DiFMUP as substrate preincubated for 10 mins f...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 4.78E+5nMAssay Description:Inhibition of human N-terminal His6-tagged TCPTP catalytic domain (1 to 336 residues) expressed in Escherichia coli strain Rosetta2 (DE3) using DiFMU...More data for this Ligand-Target Pair
TargetReceptor-type tyrosine-protein phosphatase epsilon(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: >5.00E+5nMAssay Description:Inhibition of human PTPRE (107 to 707 residues) expressed in Escherichia coli strain BL21(DE3) using DiFMUP as substrate preincubated for 10 mins fol...More data for this Ligand-Target Pair
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Helmholtz Zentrum M�Nchen
Curated by ChEMBL
Affinity DataIC50: 9.10E+5nMAssay Description:Inhibition of human N-terminal His6-tagged PTP1B catalytic domain (1 to 393 residues) expressed in Escherichia coli strain Rosetta2 (DE3) using DiFMU...More data for this Ligand-Target Pair
Affinity DataEC50: 0.0770nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.470nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0680nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0480nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0870nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0680nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0730nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0800nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 50nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.70nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 2.40nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: >1.00E+3nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0460nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0580nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0780nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0760nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.590nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0550nMAssay Description:Agonist activity at GCGR expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 3.30nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0330nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.600nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.170nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 1.10nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.230nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.260nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.130nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.120nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.570nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.580nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.580nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0710nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0150nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0260nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0750nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0280nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0750nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0680nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair
Affinity DataEC50: 0.0870nMAssay Description:Agonist activity at GLP1R expressed in HEK293 cells assessed as stimulation of cAMP production by luciferase reporter gene assayMore data for this Ligand-Target Pair