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Target
Glucagon-like peptide 1 receptor
Ligand
BDBM50324714
Substrate
n/a
Meas. Tech.
ChEMBL_651180 (CHEMBL1227945)
EC50
0.075±n/a nM
Citation
 Day, JW; Ottaway, N; Patterson, JT; Gelfanov, V; Smiley, D; Gidda, J; Findeisen, H; Bruemmer, D; Drucker, DJ; Chaudhary, N; Holland, J; Hembree, J; Abplanalp, W; Grant, E; Ruehl, J; Wilson, H; Kirchner, H; Lockie, SH; Hofmann, S; Woods, SC; Nogueiras, R; Pfluger, PT; Perez-Tilve, D; DiMarchi, R; Tschöp, MH A new glucagon and GLP-1 co-agonist eliminates obesity in rodents. Nat Chem Biol 5:749-57 (2009) [PubMed]  Article 
Target
Name:
Glucagon-like peptide 1 receptor
Synonyms:
GLP-1 receptor | GLP-1-R | GLP-1R | GLP1R | GLP1R_HUMAN | Glucagon-like peptide 1 receptor | Glucagon-like peptide 1 receptor (GLP-1)
Type:
Enzyme
Mol. Mass.:
53035.78
Organism:
Homo sapiens (Human)
Description:
P43220
Residue:
463
Sequence:
MAGAPGPLRLALLLLGMVGRAGPRPQGATVSLWETVQKWREYRRQCQRSLTEDPPPATDLFCNRTFDEYACWPDGEPGSFVNVSCPWYLPWASSVPQGHVYRFCTAEGLWLQKDNSSLPWRDLSECEESKRGERSSPEEQLLFLYIIYTVGYALSFSALVIASAILLGFRHLHCTRNYIHLNLFASFILRALSVFIKDAALKWMYSTAAQQHQWDGLLSYQDSLSCRLVFLLMQYCVAANYYWLLVEGVYLYTLLAFSVLSEQWIFRLYVSIGWGVPLLFVVPWGIVKYLYEDEGCWTRNSNMNYWLIIRLPILFAIGVNFLIFVRVICIVVSKLKANLMCKTDIKCRLAKSTLTLIPLLGTHEVIFAFVMDEHARGTLRFIKLFTELSFTSFQGLMVAILYCFVNNEVQLEFRKSWERWRLEHLHIQRDSSMKPLKCPTSSLSSGATAGSSMYTATCQASCS
  
Inhibitor
Name:
BDBM50324714
Synonyms:
CHEMBL1222088
Type:
Small organic molecule
Emp. Form.:
C155H227N41O50S
Mol. Mass.:
3496.771
SMILES:
CSCC[C@H](NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1c[nH]c2ccccc12)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CCCCN)NC(=O)[C@H](C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CCC(O)=O)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CCCCN)NC(=O)[C@H](CO)NC(=O)[C@H](Cc1ccc(O)cc1)NC(=O)[C@H](CC(O)=O)NC(=O)[C@H](CO)NC(=O)[C@@H](NC(=O)[C@H](Cc1ccccc1)NC(=O)[C@@H](NC(=O)CNC(=O)[C@H](CCC(N)=O)NC(=O)[C@H](CO)N[C@@H](Cc1cnc[nH]1)C(O)=O)[C@@H](C)O)[C@@H](C)O)C(C)C)C(=O)N[C@@H](CC(N)=O)C(=O)N[C@@H]([C@@H](C)O)C(N)=O |r,wU:178.191,168.175,148.161,133.142,113.120,96.104,76.86,62.70,43.53,30.37,8.12,232.238,206.214,wD:197.208,189.195,220.228,174.179,223.231,160.169,142.148,121.133,105.112,87.95,71.74,54.61,39.41,16.28,4.4,240.246,241.249,210.215,(49.7,-5.19,;48.4,-4.39,;48.4,-2.8,;47.09,-2.01,;47.09,-.42,;45.78,.38,;44.48,-.41,;44.48,-2.01,;43.16,.38,;43.16,1.97,;44.48,2.77,;44.48,4.36,;45.79,1.97,;41.85,-.41,;40.54,.39,;40.54,1.97,;39.24,-.41,;39.24,-2,;40.54,-2.79,;41.92,-2.15,;42.94,-3.33,;42.18,-4.72,;42.64,-6.22,;41.62,-7.4,;40.15,-7.06,;39.68,-5.55,;40.7,-4.38,;37.93,.39,;36.62,-.4,;36.62,-2,;35.31,.39,;35.31,1.98,;36.62,2.78,;36.62,4.37,;35.31,5.17,;37.93,5.16,;33.99,-.4,;32.69,.39,;32.69,1.98,;31.38,-.4,;30.07,.4,;28.76,-.39,;28.76,-1.99,;27.45,.4,;27.45,1.99,;28.76,2.79,;30.07,1.98,;31.38,2.78,;31.38,4.37,;30.07,5.17,;28.77,4.38,;26.15,-.39,;24.82,.4,;24.82,1.99,;23.52,-.39,;23.52,-1.98,;24.86,-2.75,;26.2,-1.98,;24.86,-4.29,;22.21,.41,;20.9,-.39,;20.9,-1.98,;19.59,.41,;19.59,2,;20.9,2.8,;20.9,4.39,;19.57,5.16,;19.57,6.7,;18.27,-.38,;16.97,.41,;16.97,2,;15.65,-.38,;15.65,-1.97,;14.36,.42,;13.04,-.37,;13.04,-1.97,;11.74,.42,;11.74,2,;13.07,2.78,;13.07,4.32,;14.39,5.09,;14.39,6.63,;15.74,7.4,;13.07,7.4,;10.43,-.37,;9.11,.42,;9.11,2.02,;7.8,-.36,;7.8,-1.96,;9.11,-2.76,;9.11,-4.35,;10.42,-5.14,;7.76,-5.11,;6.48,.43,;5.19,-.35,;5.19,-1.96,;3.87,.44,;3.87,2.02,;5.22,2.79,;5.22,4.34,;3.87,5.12,;6.55,5.12,;2.58,-.35,;1.25,.44,;1.25,2.03,;-.06,-.35,;-.06,-1.95,;1.25,-2.74,;2.56,-1.95,;1.25,-4.33,;-1.36,.44,;-2.67,-.34,;-2.67,-1.94,;-3.98,.45,;-3.98,2.03,;-2.67,2.83,;-2.67,4.42,;-1.36,2.03,;-5.29,-.34,;-6.6,.45,;-6.6,2.03,;-7.9,-.34,;-7.9,-1.94,;-6.6,-2.73,;-5.29,-1.94,;-3.98,-2.74,;-3.99,-4.33,;-2.68,-5.12,;-5.3,-5.12,;-6.6,-4.32,;-9.24,.45,;-10.53,-.33,;-10.53,-1.93,;-11.83,.45,;-11.83,2.04,;-10.53,2.84,;-10.53,4.43,;-9.23,5.24,;-9.23,6.83,;-13.14,-.33,;-14.45,.46,;-14.45,2.04,;-15.77,-.33,;-15.77,-1.93,;-14.45,-2.72,;-17.08,.46,;-18.38,-.32,;-18.38,-1.92,;-19.7,.46,;-19.7,2.05,;-18.38,2.85,;-17.07,2.05,;-15.77,2.85,;-15.76,4.44,;-14.44,5.24,;-17.08,5.25,;-18.38,4.44,;-21,-.32,;-22.31,.47,;-22.31,2.05,;-23.63,-.32,;-23.63,-1.91,;-22.31,-2.71,;-21.01,-1.91,;-22.31,-4.3,;-24.93,.47,;-26.25,-.32,;-26.25,-1.91,;-27.55,.47,;-27.55,2.06,;-26.25,2.86,;-28.86,-.31,;-30.18,.48,;-30.18,2.06,;-31.47,-.31,;-32.81,.48,;-34.09,-.31,;-34.09,-1.9,;-35.41,.48,;-35.41,2.07,;-34.09,2.87,;-32.79,2.06,;-31.47,2.87,;-31.47,4.45,;-32.8,5.26,;-34.1,4.46,;-36.71,-.3,;-38.02,.48,;-38.02,2.07,;-39.35,-.3,;-40.65,.49,;-41.95,-.3,;-41.95,-1.89,;-43.26,.49,;-44.58,-.29,;-45.88,.49,;-45.88,2.08,;-47.19,-.29,;-47.19,-1.88,;-45.88,-2.68,;-45.88,-4.28,;-47.2,-5.07,;-44.59,-5.07,;-48.5,.5,;-49.81,-.29,;-49.81,-1.88,;-51.13,.5,;-51.13,2.09,;-49.81,2.89,;-52.43,-.29,;-53.77,.49,;-53.77,2.01,;-55.09,2.77,;-56.34,1.91,;-57.57,2.83,;-57.07,4.29,;-55.53,4.26,;-55.1,-.28,;-56.42,.49,;-55.1,-1.82,;-39.35,-1.89,;-40.65,-2.7,;-38.02,-2.69,;-31.47,-1.9,;-32.81,-2.7,;-30.18,-2.7,;31.38,-1.99,;32.69,-2.78,;30.07,-2.79,;48.4,.38,;48.4,1.96,;49.72,-.42,;51.01,.37,;51.01,1.96,;52.33,2.76,;53.64,1.96,;52.33,4.35,;52.33,-.42,;52.33,-2.01,;53.64,.37,;54.95,-.43,;54.95,-2.02,;53.64,-2.81,;56.26,-2.81,;56.26,.37,;57.57,-.43,;56.26,1.95,)|
Structure:
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