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Found 4649 with Last Name = 'pinder' and Initial = 'j'
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513177(CHEMBL4444602)
Affinity DataKi:  0.140nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM350085(3-[3-[4-[dideuterio(methylamino)methyl]phenyl]isox...)
Affinity DataKi:  0.165nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM420857(US10479784, Compound IIA-10 | US10961232, Compound...)
Affinity DataKi:  0.210nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM420852(US10479784, Compound IIA-5 | US10961232, Compound ...)
Affinity DataKi:  0.270nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513173(CHEMBL4566104)
Affinity DataKi:  0.530nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  0.600nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513176(CHEMBL4448538)
Affinity DataKi:  0.75nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277679(CHEMBL484006 | N-(4-(4-(4-tert-butylpiperazin-1-yl...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513178(CHEMBL4434665)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293690(CHEMBL564941 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM420609(US10479784, Compound IA-116 | US10961232, Compound...)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293686(CHEMBL559900 | N-(5-methyl-1H-pyrazol-3-yl)-2-(nap...)
Affinity DataKi:  1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277678(CHEMBL485186 | N-(4-(4-(4-cyclopropylpiperazin-1-y...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293689(CHEMBL549668 | N-methyl-N-(4-(4-(5-methyl-1H-pyraz...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277640(CHEMBL485351 | N-(4-(4-(4-ethylpiperazin-1-yl)-6-(...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293669(CHEMBL564449 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513181(CHEMBL4440048)
Affinity DataKi:  1nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293671(CHEMBL561421 | N-(4-(4-(5-cyclopropyl-1H-pyrazol-3...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293699(CHEMBL554941 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <1nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513172(CHEMBL4467848)
Affinity DataKi:  1.20nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277679(CHEMBL484006 | N-(4-(4-(4-tert-butylpiperazin-1-yl...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277639(CHEMBL484609 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277586(CHEMBL484951 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.60nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277637(CHEMBL482778 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  1.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase B(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM13534(CHEMBL572878 | N-[4-({4-[(3-methyl-1H-pyrazol-5-yl...)
Affinity DataKi:  1.80nMAssay Description:Inhibition of Aurora-B by time dependent kinetic studyMore data for this Ligand-Target Pair
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293680(2-(2,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293687(CHEMBL552033 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293682(2-(3,4-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  2nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513175(CHEMBL4530813)
Affinity DataKi:  2nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293698(CHEMBL563682 | N-(4-(4-(azetidin-1-yl)-6-(5-methyl...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293693(CHEMBL557279 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM420860(US10479784, Compound IIA-13 | US10961232, Compound...)
Affinity DataKi:  2.40nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand Info
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293700(CHEMBL560630 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi: <3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293679(2-(2,3-dichlorophenylthio)-N-(5-methyl-1H-pyrazol-...)
Affinity DataKi:  3nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277638(CHEMBL482779 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  3.70nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293695(CHEMBL561617 | N-(4-(4-cyclopropyl-6-(5-methyl-1H-...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293697(CHEMBL557682 | N-(4-(4-(5-methyl-1H-pyrazol-3-ylam...)
Affinity DataKi:  3.90nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50341747(3-amino-6-(4-(isopropylsulfonyl)phenyl)-N-phenylpy...)
Affinity DataKi:  4nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50277585(CHEMBL484950 | N-(4-(4-(3-methyl-1H-pyrazol-5-ylam...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAurora kinase A(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50293677(2-(3-chlorophenylthio)-N-(5-methyl-1H-pyrazol-3-yl...)
Affinity DataKi:  4nMAssay Description:Inhibition of Aurora-A by coupled assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM50513179(CHEMBL4558884)
Affinity DataKi:  4nMAssay Description:Inhibition of recombinant human full-length N-terminal Flag epitope-tagged ATR expressed in HEK293T cells using ASELPASQPQPFSAKKK peptide as substrat...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323349(US9630956, Compound I-86)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323350(US9630956, Compound I-87)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323351(US9630956, Compound I-88)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323352(US9630956, Compound I-89)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323353(US9630956, Compound I-90)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323354(US9630956, Compound I-91)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323355(US9630956, Compound I-92)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323356(US9630956, Compound I-93)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetSerine/threonine-protein kinase ATR(Homo sapiens (Human))
Vertex Pharmaceuticals (Europe)

Curated by ChEMBL
LigandPNGBDBM323357(US9630956, Compound I-94)
Affinity DataKi: <5nMAssay Description:Compounds were screened for their ability to inhibit ATR kinase using a radioactive-phosphate incorporation assay. Assays were carried out in a mixtu...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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