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Found 109 with Last Name = 'ravna' and Initial = 'aw'
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50073436((2-(2-((dimethylamino)methyl)phenylthio)-5-iodophe...)
Affinity DataKi:  0.100nMAssay Description:Displacement of [125I]IPT from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50063266(6-Nitro-2-piperazin-1-yl-quinoline | 6-nitroquipaz...)
Affinity DataKi:  0.170nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264817(CHEMBL491028 | N-(5-chloro-2-(2-((dimethylamino)me...)
Affinity DataKi:  0.900nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]paroxetine from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  1.70nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105212(2-(4-Nonyl-piperazin-1-yl)-6-nitroquinoline (9))
Affinity DataKi:  1.80nM ΔG°:  -49.9kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105213(2-(4-Decyl-piperazin-1-yl)-6-nitroquinoline (10))
Affinity DataKi:  4.5nM ΔG°:  -47.6kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264818(CHEMBL490416 | N-(5-bromo-2-(2-((dimethylamino)met...)
Affinity DataKi:  8nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265295(CHEMBL497140 | N,N-Dimethyl-2-[2-(N-4-fluorobenzyl...)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25876(4,4-dimethyl-1-{4-[4-(quinolin-2-yl)piperazin-1-yl...)
Affinity DataKi:  11nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105214(2-(4-Undecyl-piperazin-1-yl)-6-nitroquinoline (11))
Affinity DataKi:  12.6nM ΔG°:  -45.1kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25869(2-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  13nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265291(CHEMBL525371 | N,N-Dimethyl-2-[2-(N-4-fluorobenzam...)
Affinity DataKi:  14nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363815(CHEMBL1945686)
Affinity DataKi:  15nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105215(2-(4-Dodecyl-piperazin-1-yl)-6-nitroquinoline (12))
Affinity DataKi:  16.1nM ΔG°:  -44.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105211(2-(4-Octyl-piperazin-1-yl)-6-nitroquinoline (8))
Affinity DataKi:  20.8nM ΔG°:  -43.8kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25873(8-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  24nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105207(2-(4-Butyl-piperazin-1-yl)-6-nitroquinoline (4))
Affinity DataKi:  24nM ΔG°:  -43.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  30nMAssay Description:Displacement of [3H]-5HT from human SERTMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264816(CHEMBL491027 | N-(2-(2-((dimethylamino)methyl)phen...)
Affinity DataKi:  34nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25871(1-{4-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]but...)
Affinity DataKi:  37nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25875(8-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-8-aza...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25874(2-{4-[4-(quinolin-2-yl)piperazin-1-yl]butyl}-2,3-d...)
Affinity DataKi:  39nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105210(2-(4-Heptyl-piperazin-1-yl)-6-nitroquinoline (7))
Affinity DataKi:  54.1nM ΔG°:  -41.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265294(CHEMBL496938 | N,N-Dimethyl-2-[2-(N-4-nitrobenzyla...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM54115(5-[4-Ethoxy-3-(1-methyl-7-oxo-3-propyl-6,7-dihydro...)
Affinity DataKi:  65.3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105209(2-(4-Hexyl-piperazin-1-yl)-6-nitroquinoline (6))
Affinity DataKi:  72.9nM ΔG°:  -40.7kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM50386476(CHEMBL2047880)
Affinity DataKi:  75.3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105208(2-(4-Pentyl-piperazin-1-yl)-6-nitroquinoline (5))
Affinity DataKi:  80.5nM ΔG°:  -40.5kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105205(2-(4-Ethyl-piperazin-1-yl)-6-nitroquinoline (2))
Affinity DataKi:  86.1nM ΔG°:  -40.3kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265293(CHEMBL450184 | N-Methyl-2-[2-(N-4-fluorobenzylamin...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265292(CHEMBL498367 | N,N-Dimethyl-2-[2-(N-4-nitrobenzami...)
Affinity DataKi: >100nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264819(CHEMBL522444 | N-(2-(2-((dimethylamino)methyl)phen...)
Affinity DataKi:  193nMAssay Description:Displacement of [125I]IDAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363810(CHEMBL1945681)
Affinity DataKi:  221nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50014407(2-(piperazin-1-yl)quinoline | 2-Piperazin-1-yl-qui...)
Affinity DataKi:  230nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM25872(2-{3-[2-methyl-4-(quinolin-2-yl)piperazin-1-yl]pro...)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi:  325nMAssay Description:Displacement of [3H]nisoxetine from human cloned NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM105206(2-(4-Propyl-piperazin-1-yl)-6-nitroquinoline (3))
Affinity DataKi:  496nM ΔG°:  -36.0kJ/molepH: 7.7 T: 2°CAssay Description:The assay was performed in accordance with the method described by Owens et al. with slight modifications. Rat cerebral cortex was homogenized in 30...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent serotonin transporter(Rattus norvegicus (rat))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264820(CHEMBL451264 | N-Methyl-2-[2-(N-4-fluorobenzamide)...)
Affinity DataKi: >500nMAssay Description:Displacement of [3H]MADAM from SERT in rat brain cortex membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363806(CHEMBL1945475)
Affinity DataKi:  711nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363808(CHEMBL1945679)
Affinity DataKi:  777nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50110788(2-(2-((dimethylamino)methyl)phenylthio)-5-methylan...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GBR12935 from human cloned DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265293(CHEMBL450184 | N-Methyl-2-[2-(N-4-fluorobenzylamin...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]nisoxetine from human cloned NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50264820(CHEMBL451264 | N-Methyl-2-[2-(N-4-fluorobenzamide)...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GBR12935 from human cloned DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265291(CHEMBL525371 | N,N-Dimethyl-2-[2-(N-4-fluorobenzam...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GBR12935 from human cloned DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265292(CHEMBL498367 | N,N-Dimethyl-2-[2-(N-4-nitrobenzami...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GBR12935 from human cloned DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent dopamine transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265294(CHEMBL496938 | N,N-Dimethyl-2-[2-(N-4-nitrobenzyla...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]GBR12935 from human cloned DAT expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSodium-dependent noradrenaline transporter(Homo sapiens (Human))
University Of Tours

Curated by ChEMBL
LigandPNGBDBM50265292(CHEMBL498367 | N,N-Dimethyl-2-[2-(N-4-nitrobenzami...)
Affinity DataKi: >1.00E+3nMAssay Description:Displacement of [3H]nisoxetine from human cloned NET expressed in HEK293 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
National Medicines Institute

Curated by ChEMBL
LigandPNGBDBM50363809(CHEMBL1945680)
Affinity DataKi:  1.10E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from 5HT1A receptor in cerebral cortex homogenates after 15 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-binding cassette sub-family C member 5(Homo sapiens (Human))
University Of Troms£

Curated by ChEMBL
LigandPNGBDBM14390(5-[2-ethoxy-5-(4-methyl-1-piperazinylsulfonyl)phen...)
Affinity DataKi:  1.20E+3nMAssay Description:Inhibition of ABCC5 in human erythrocytes assessed as inhibition of ATP-mediated [3H]cGMP uptake in inside-out vesicles after 60 mins by liquid scint...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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