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Found 35 with Last Name = 'robertson' and Initial = 'as'
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105466((S)-6-Amino-2-[(R)-2-[(4-benzenesulfonyl-piperazin...)
Affinity DataIC50:  2.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105472((S)-6-Amino-2-[(R)-2-[(1-benzenesulfonyl-piperidin...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105465((4R,8S,11S,17S)-8-(4-Amino-butyl)-17-(2-amino-3-na...)
Affinity DataIC50:  4.10nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105470((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(4-meth...)
Affinity DataIC50:  4.40nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105469((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(2-oxo-...)
Affinity DataIC50:  6.5nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105469((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(2-oxo-...)
Affinity DataIC50:  6.5nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105468((S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carb...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105468((S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carb...)
Affinity DataIC50:  6.90nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105471((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(toluen...)
Affinity DataIC50:  9.20nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105466((S)-6-Amino-2-[(R)-2-[(4-benzenesulfonyl-piperazin...)
Affinity DataIC50:  29nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105470((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(4-meth...)
Affinity DataIC50:  67nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105472((S)-6-Amino-2-[(R)-2-[(1-benzenesulfonyl-piperidin...)
Affinity DataIC50:  120nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105465((4R,8S,11S,17S)-8-(4-Amino-butyl)-17-(2-amino-3-na...)
Affinity DataIC50:  270nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105467((S)-6-Amino-2-[(S)-2-[(biphenyl-4-carbonyl)-amino]...)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105467((S)-6-Amino-2-[(S)-2-[(biphenyl-4-carbonyl)-amino]...)
Affinity DataIC50:  1.20E+3nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105473((S)-2-[(S)-3-(3-Fluoro-phenyl)-2-(toluene-4-sulfon...)
Affinity DataIC50: >2.00E+3nMAssay Description:Inhibitory concentration of the compound towards binding of sst2 receptor using [125I]-somatostatin as radioligand in Neuro2A cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105473((S)-2-[(S)-3-(3-Fluoro-phenyl)-2-(toluene-4-sulfon...)
Affinity DataIC50:  6.50E+3nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSomatostatin receptor type 2(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50105471((S)-6-Amino-2-((R)-3-(1H-indol-3-yl)-2-{[4-(toluen...)
Affinity DataIC50:  7.70E+3nMAssay Description:Antagonistic activity of the compound towards sst2 receptor in GH4C1 cells a concentration of 1-2 x 10e6/mL incubated for 20 minutesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394690(CHEMBL2165624)
Affinity DataEC50:  2.49E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394691(CHEMBL2165623)
Affinity DataEC50:  565nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394692(CHEMBL2165622)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394693(CHEMBL2165621)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  90nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394682(CHEMBL2165619)
Affinity DataEC50:  114nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  900nMAssay Description:Induction of glucokinase translocation from nucleus to cytoplasm in cryopreserved rat hepatocytes after 1 hr by Hoechst staining-based fluorescence m...More data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  190nMAssay Description:Induction of glucokinase translocation from nucleus to cytoplasm in cryopreserved rat hepatocytes after 1 hr by Hoechst staining-based fluorescence m...More data for this Ligand-Target Pair
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394681(CHEMBL2165620)
Affinity DataEC50:  6.90E+3nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as stimulation of glucose-induced insulin secretionMore data for this Ligand-Target Pair
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394689(CHEMBL2165625)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394688(CHEMBL2165626)
Affinity DataEC50:  284nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394687(CHEMBL2165627)
Affinity DataEC50:  456nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394686(CHEMBL2165617)
Affinity DataEC50:  1.08E+3nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394685(CHEMBL2165618)
Affinity DataEC50: >1.00E+4nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Rattus norvegicus)
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394682(CHEMBL2165619)
Affinity DataEC50:  153nMAssay Description:Activation of glucokinase in rat INS-1 cells assessed as stimulation of glucose-induced insulin secretionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394683(CHEMBL2165616)
Affinity DataEC50:  212nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50394684(CHEMBL2165615)
Affinity DataEC50:  188nMAssay Description:Activation of human recombinant glucokinase using 6.5 mM glucose by spectrophotometric analysisMore data for this Ligand-Target Pair