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Target
Somatostatin receptor type 2
Ligand
BDBM50105468
Substrate
n/a
Meas. Tech.
ChEMBL_200992 (CHEMBL801243)
IC50
6.9±n/a nM
Citation
 Hay, BA; Cole, BM; DiCapua, FM; Kirk, GW; Murray, MC; Nardone, RA; Pelletier, DJ; Ricketts, AP; Robertson, AS; Siegel, TW Small molecule somatostatin receptor subtype-2 antagonists. Bioorg Med Chem Lett 11:2731-4 (2001) [PubMed]  Article 
Target
Name:
Somatostatin receptor type 2
Synonyms:
SOMATOSTATIN SST2 | SRIF-1 | SS-2-R | SS2-R | SS2R | SSR2_HUMAN | SSTR2 | Somatostatin receptor type 2 (SSTR2)
Type:
Enzyme
Mol. Mass.:
41344.94
Organism:
Homo sapiens (Human)
Description:
P30874
Residue:
369
Sequence:
MDMADEPLNGSHTWLSIPFDLNGSVVSTNTSNQTEPYYDLTSNAVLTFIYFVVCIIGLCGNTLVIYVILRYAKMKTITNIYILNLAIADELFMLGLPFLAMQVALVHWPFGKAICRVVMTVDGINQFTSIFCLTVMSIDRYLAVVHPIKSAKWRRPRTAKMITMAVWGVSLLVILPIMIYAGLRSNQWGRSSCTINWPGESGAWYTGFIIYTFILGFLVPLTIICLCYLFIIIKVKSSGIRVGSSKRKKSEKKVTRMVSIVVAVFIFCWLPFYIFNVSSVSMAISPTPALKGMFDFVVVLTYANSCANPILYAFLSDNFKKSFQNVLCLVKVSGTDDGERSDSKQDKSRLNETTETQRTLLNGDLQTSI
  
Inhibitor
Name:
BDBM50105468
Synonyms:
(S)-6-Amino-2-[(R)-2-[(4-benzoyl-piperazine-1-carbonyl)-amino]-3-(1H-indol-3-yl)-propionylamino]-hexanoic acid tert-butyl ester | CHEMBL93304
Type:
Small organic molecule
Emp. Form.:
C33H44N6O5
Mol. Mass.:
604.7397
SMILES:
CC(C)(C)OC(=O)[C@H](CCCCN)NC(=O)[C@@H](Cc1c[nH]c2ccccc12)NC(=O)N1CCN(CC1)C(=O)c1ccccc1
Structure:
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