Affinity DataIC50: 0.350nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 0.526nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 0.540nMAssay Description:Inhibition of RET (658 to 1072) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 0.730nMAssay Description:Inhibition of RET (658 to 1072) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 0.850nMAssay Description:Inhibition of RET (658 to 1072) (unknown origin) by HTRF assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of NGF-activated full length TRKA (unknown origin) expressed in mouse BA/F3 cells assessed as inhibition of cell proliferationMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of TPM3-fused TRKA (unknown origin) expressed in human KM12 cells assessed as inhibition of cell proliferation after 48 hrs by luciferase ...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: <1nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 1.18nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 1.22nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 1.31nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 1.70nMAssay Description:Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l...More data for this Ligand-Target Pair
Affinity DataIC50: 1.90nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 2nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
Affinity DataIC50: 2nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.06nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 2.10nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 2.13nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.30nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.5nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 2.80nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 3nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of NGF-activated full length TRKA (unknown origin) expressed in mouse BA/F3 cells assessed as inhibition of cell proliferationMore data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetKinesin-1 heavy chain/Proto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 3.30nMAssay Description:Inhibition of KIF5B-RET (unknown origin) transfected in mouse Ba/F3 cells assessed as reduction in cell viability incubated for 48 hrs by brightglo-l...More data for this Ligand-Target Pair
TargetProto-oncogene tyrosine-protein kinase receptor Ret(Homo sapiens (Human))
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
The Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of RET (unknown origin) expressed in mouse BaF3 cells assessed as reduction in cell proliferation incubated for 48 hrs by cell proliferati...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alpha assessed as phosphorylation of fluorescently-labelled MK2 using Hsp27 peptide as substrate after 60 mins by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:Inhibition of p38alpha assessed as phosphorylation FITC-labeled Hsp27 after 60 mins by fluorescence based cascade assayMore data for this Ligand-Target Pair
Affinity DataIC50: 4nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
TargetBDNF/NT-3 growth factors receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of Tel-fused TRKB (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetNT-3 growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of Tel-fused TRKC (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Genomics Institute Of The Novartis Research Foundation
Curated by ChEMBL
Affinity DataIC50: 4nMAssay Description:Inhibition of Tel-fused TRKA (unknown origin) overexpressed in mouse BA/F3 cells assessed as inhibition of cell proliferation after 48 hrs by lucifer...More data for this Ligand-Target Pair
Affinity DataIC50: 4.20nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair
Affinity DataIC50: 4.30nMAssay Description:The glucocorticoid receptor fluorescence polarization ligand binding (GRFP) assay is used to evaluate direct binding of testing compounds to full-len...More data for this Ligand-Target Pair