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Found 126 with Last Name = 'sakuma' and Initial = 's'
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366072(5-[4-[5-(2-Methoxybenzyl)-1H-tetrazol-1-yl]phenyl]...)
Affinity DataIC50:  25nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366073(5-[4-[5-(2-Hydroxybenzyl)-1H-tetrazol-1-yl]phenyl]...)
Affinity DataIC50:  37nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366069(US9873683, Example 79)
Affinity DataIC50:  39nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366075(5-[4-(5-Phenethyl-1H-tetrazol-1-yl)phenyl]-1H-naph...)
Affinity DataIC50:  44nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365870(US9873683, Example 31)
Affinity DataIC50:  51nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366049(US9873683, Example 43)
Affinity DataIC50:  53nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366062(US9873683, Example 67)
Affinity DataIC50:  53nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393615(US09969700, 173)
Affinity DataIC50:  64nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366057(US9873683, Example 61)
Affinity DataIC50:  74nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366078(5-[6-[5-(2-Hydroxybenzyl)-1H-tetrazol-1-yl]pyridin...)
Affinity DataIC50:  77nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366077(5-[4-(2-Phenethyl-1H-imidazol-1-yl)phenyl]-1H-naph...)
Affinity DataIC50:  78nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365827(US9873683, Example 27)
Affinity DataIC50:  78nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365950(US9873683, Example 37)
Affinity DataIC50:  79nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365816(US9873683, Example 25)
Affinity DataIC50:  82nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366071(US9873683, Example 83)
Affinity DataIC50:  87nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366058(US9873683, Example 62)
Affinity DataIC50:  88nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365756(US9873683, Example 22)
Affinity DataIC50:  91nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366048(US9873683, Example 42)
Affinity DataIC50:  92nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366050(US9873683, Example 47)
Affinity DataIC50:  94nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366060(US9873683, Example 65)
Affinity DataIC50:  130nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366056(US9873683, Example 57)
Affinity DataIC50:  130nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365944(US9873683, Example 32)
Affinity DataIC50:  180nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366054(US9873683, Example 54)
Affinity DataIC50:  190nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365840(US9873683, Example 30)
Affinity DataIC50:  270nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365785(US9873683, Example 23)
Affinity DataIC50:  300nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366076(5-[4-[5-(2-Methoxybenzyl)-1H-tetrazol-1-yl]phenyl]...)
Affinity DataIC50:  320nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366067(US9873683, Example 73)
Affinity DataIC50:  320nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366055(US9873683, Example 55)
Affinity DataIC50:  340nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366074(5-[4-[5-[2-(Pyridin-3-yl)ethyl]-1H-tetrazol-1-yl]p...)
Affinity DataIC50:  380nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393614(US09969700, 48)
Affinity DataIC50:  430nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393617(US09969700, 197)
Affinity DataIC50:  440nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366059(US9873683, Example 64)
Affinity DataIC50:  520nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393612(5-[4-[(2-Chlorophenylacetyl)amino]phenyl]-1H-napht...)
Affinity DataIC50:  540nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM365989(US9873683, Example 38)
Affinity DataIC50:  550nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366061(US9873683, Example 66)
Affinity DataIC50:  550nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366053(US9873683, Example 53)
Affinity DataIC50:  590nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366065(US9873683, Example 71)
Affinity DataIC50:  590nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366046(US9873683, Example 40)
Affinity DataIC50:  630nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366047(US9873683, Example 41)
Affinity DataIC50:  650nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366063(US9873683, Example 68)
Affinity DataIC50:  790nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393616(US09969700, 196)
Affinity DataIC50:  970nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393613(US09969700, 20)
Affinity DataIC50:  1.20E+3nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366070(US9873683, Example 80)
Affinity DataIC50:  1.30E+3nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366052(US9873683, Example 51)
Affinity DataIC50:  1.70E+3nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM393619(5-[4-(2-Iodobenzoyl)aminophenyl]-1,2,3,4,8,9,10,11...)
Affinity DataIC50:  1.80E+3nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366068(US9873683, Example 74)
Affinity DataIC50:  2.50E+3nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366066(US9873683, Example 72)
Affinity DataIC50:  3.40E+3nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM366051(US9873683, Example 50)
Affinity DataIC50:  3.70E+3nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM22416((3S,4R)-3-[(1,3-benzodioxol-5-yloxy)methyl]-4-(4-f...)
Affinity DataIC50:  4.00E+3nMAssay Description:The P2X4 receptor antagonist activity of the compounds of the present invention was measured as follows. The 1321N1 cells stably expressing human P2X...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetP2X purinoceptor 4(Homo sapiens (Human))
Nippon Chemiphar

US Patent
LigandPNGBDBM86422(CAS_61869-08-7 | NSC_43815 | PAROXETINE | US987368...)
Affinity DataIC50:  4.00E+3nMAssay Description:The 1321N1 cells stably expressing human P2X4 receptor were seeded on a 96-well plate, cultured under the conditions of 37° C. and 5% CO2 for 24 hour...More data for this Ligand-Target Pair
In DepthDetails US Patent
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