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Found 590 with Last Name = 'sasaki' and Initial = 'm'
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591389(CHEMBL5179778)
Affinity DataKi:  56nMAssay Description:Irreversible inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substr...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM50591390(CHEMBL5190754)
Affinity DataKi:  224nMAssay Description:Irreversible inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substr...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetyl-CoA carboxylase 1(Mus musculus)
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50247081(CHEMBL4060253)
Affinity DataIC50:  0.180nMAssay Description:Inhibition of mouse His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by subst...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99943(US8501750, 56)
Affinity DataIC50:  0.340nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50247130(CHEMBL4073202)
Affinity DataIC50:  0.580nMAssay Description:Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-Co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50459632(CHEMBL4204645)
Affinity DataIC50:  0.640nMAssay Description:Inhibition of His-tagged human MAGL expressed in Escherichia coli BL21(DE3) assessed as reduction in arachidonic acid production from 2-arachidonoylg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50247081(CHEMBL4060253)
Affinity DataIC50:  0.760nMAssay Description:Inhibition of ACC1 in human HCT116 cells assessed as reduction of [14C]acetate uptake preincubated for 60 mins followed by addition of [14C]acetate a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99950(US8501750, 83)
Affinity DataIC50:  0.770nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetReplicase polyprotein 1ab(2019-nCoV)
Kyushu University

Curated by ChEMBL
LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of recombinant full length SARS-CoV-2 3CLpro expressed in Escherichia coli using Ac-Abu-Tle-Leu-Gln-MCA as fluorogenic substrate preincuba...More data for this Ligand-Target Pair
TargetEnteropeptidase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50595346(CHEMBL5189108)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of human recombinant Enteropeptidase assessed as inhibition based on steady state using 5FAM-Abu-Gly-Asp -Asp-Asp -Lys-Ile-Val-Gly-Gly-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnteropeptidase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50595346(CHEMBL5189108)
Affinity DataIC50:  0.810nMAssay Description:Inhibition of human recombinant Enteropeptidase assessed as inhibition based on steady state using 5FAM-Abu-Gly-Asp -Asp-Asp -Lys-Ile-Val-Gly-Gly-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnteropeptidase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50595349(CHEMBL5202756)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human recombinant Enteropeptidase assessed as inhibition based on steady state using 5FAM-Abu-Gly-Asp -Asp-Asp -Lys-Ile-Val-Gly-Gly-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnteropeptidase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50595349(CHEMBL5202756)
Affinity DataIC50:  0.820nMAssay Description:Inhibition of human recombinant Enteropeptidase assessed as inhibition based on steady state using 5FAM-Abu-Gly-Asp -Asp-Asp -Lys-Ile-Val-Gly-Gly-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50247114(CHEMBL4086127)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-Co...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50247112(CHEMBL4085633)
Affinity DataIC50:  0.960nMAssay Description:Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-Co...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99952(US8501750, 105)
Affinity DataIC50:  1nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99949(US8501750, 76)
Affinity DataIC50:  1nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99946(US8501750, 60)
Affinity DataIC50:  1nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99953(US8501750, 107)
Affinity DataIC50:  1.10nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99947(US8501750, 63)
Affinity DataIC50:  1.10nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of DPP4 in human Caco2 cells after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99961(US8501750, 131)
Affinity DataIC50:  1.20nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99951(US8501750, 99)
Affinity DataIC50:  1.20nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99945(US8501750, 59)
Affinity DataIC50:  1.20nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetStearoyl-CoA desaturase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50267928(CHEMBL4066506)
Affinity DataIC50:  1.20nMAssay Description:Displacement of (5-(6-(10H-spiro(1-benzofuran-3,30-pyrrolidin)-10-yl)pyridazin-3-yl)-1,2,4-oxadiazol-3-yl)[3H2]methanol from SCD1 in human liver micr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMonoglyceride lipase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50459647(CHEMBL4205102)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of His-tagged human MAGL expressed in Escherichia coli BL21(DE3) assessed as reduction in arachidonic acid production from 2-arachidonoylg...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetEnteropeptidase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50595352(CHEMBL5175180)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant Enteropeptidase assessed as inhibition based on steady state using 5FAM-Abu-Gly-Asp -Asp-Asp -Lys-Ile-Val-Gly-Gly-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetEnteropeptidase(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50595352(CHEMBL5175180)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of human recombinant Enteropeptidase assessed as inhibition based on steady state using 5FAM-Abu-Gly-Asp -Asp-Asp -Lys-Ile-Val-Gly-Gly-Lys...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99981(US8501750, 186)
Affinity DataIC50:  1.20nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99980(US8501750, 181)
Affinity DataIC50:  1.20nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99974(US8501750, 153)
Affinity DataIC50:  1.30nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDipeptidyl peptidase 4(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50336806(1-(3-(aminomethyl)-2-isobutyl-4-p-tolylquinolin-6-...)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of human Dipeptidyl peptidase-4 expressed in Caco-2 cells using Gly-Pro-pNA.Tos as substrate after 60 mins by microplate reader analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99992(US8501750, 215)
Affinity DataIC50:  1.30nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99993(US8501750, 221)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99988(US8501750, 209)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99977(US8501750, 157)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99954(US8501750, 109)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99984(US8501750, 197)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99967(US8501750, 143)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99958(US8501750, 127)
Affinity DataIC50:  1.40nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99972(US8501750, 150)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99985(US8501750, 198)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99987(US8501750, 205)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99966(US8501750, 142)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99964(US8501750, 136)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99973(US8501750, 152)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAcetyl-CoA carboxylase 1(Homo sapiens (Human))
Takeda Pharmaceutical

Curated by ChEMBL
LigandPNGBDBM50529222(CHEMBL4528475)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of recombinant human His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins follo...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99963(US8501750, 135)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99948(US8501750, 73)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetType-1 angiotensin II receptor(Homo sapiens (Human))
Takeda Pharmaceutical

US Patent
LigandPNGBDBM99970(US8501750, 148)
Affinity DataIC50:  1.5nMAssay Description:Binding assay using human AT1.More data for this Ligand-Target Pair
In DepthDetails US Patent
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