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Target
Monoglyceride lipase
Ligand
BDBM50459647
Substrate
n/a
Meas. Tech.
ChEMBL_1766915 (CHEMBL4202162)
IC50
1.2±n/a nM
Citation
 Aida, J; Fushimi, M; Kusumoto, T; Sugiyama, H; Arimura, N; Ikeda, S; Sasaki, M; Sogabe, S; Aoyama, K; Koike, T Design, Synthesis, and Evaluation of Piperazinyl Pyrrolidin-2-ones as a Novel Series of Reversible Monoacylglycerol Lipase Inhibitors. J Med Chem 61:9205-9217 (2018) [PubMed]  Article 
Target
Name:
Monoglyceride lipase
Synonyms:
HU-K5 | Lysophospholipase homolog | Lysophospholipase-like | MAGL | MGL | MGLL | MGLL_HUMAN
Type:
Hydrolase
Mol. Mass.:
33264.56
Organism:
Homo sapiens (Human)
Description:
Human recombinant MGL (Cayman Chemical, cat# 10008354).
Residue:
303
Sequence:
MPEESSPRRTPQSIPYQDLPHLVNADGQYLFCRYWKPTGTPKALIFVSHGAGEHSGRYEELARMLMGLDLLVFAHDHVGHGQSEGERMVVSDFHVFVRDVLQHVDSMQKDYPGLPVFLLGHSMGGAIAILTAAERPGHFAGMVLISPLVLANPESATTFKVLAAKVLNLVLPNLSLGPIDSSVLSRNKTEVDIYNSDPLICRAGLKVCFGIQLLNAVSRVERALPKLTVPFLLLQGSADRLCDSKGAYLLMELAKSQDKTLKIYEGAYHVLHKELPEVTNSVFHEINMWVSQRTATAGTASPP
  
Inhibitor
Name:
BDBM50459647
Synonyms:
CHEMBL4205102
Type:
Small organic molecule
Emp. Form.:
C25H26N4O2S
Mol. Mass.:
446.565
SMILES:
Cc1ccccc1-c1cccc(c1)N1CC(CC1=O)N1CCN(CC1)C(=O)c1nccs1
Structure:
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