Affinity DataKi: 6.20nMAssay Description:Inhibition of hexa-His-tagged JNK2 expressed in baculoviral system using GST-tagged cJun as substrate preincubated for 15 mins prior ATP addition mea...More data for this Ligand-Target Pair
Affinity DataKi: 44nMAssay Description:Inhibition of hexa-His-tagged JNK1 expressed in baculoviral system using GST-tagged c-Jun as substrate preincubated for 15 mins prior ATP addition me...More data for this Ligand-Target Pair
Affinity DataIC50: 0.0800nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type A receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0870nMAssay Description:Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.0870nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.180nMAssay Description:Inhibition of mouse His-tagged ACC1 expressed in baculovirus infected SF9 cells using acetyl-CoA as substrate incubated for 60 mins followed by subst...More data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.200nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.230nMAssay Description:Tested for the inhibition of [125I]-PYY binding to HEK 293 cells stably expressed with human neuropeptide NPY Y5 receptorMore data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.25nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.280nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.370nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.470nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.540nMAssay Description:Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
Affinity DataIC50: 0.580nMAssay Description:Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-Co...More data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with the Human NPY-Y5 cDNA (compound prepared by para...More data for this Ligand-Target Pair
Affinity DataIC50: 0.590nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...More data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.630nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.660nMAssay Description:Compound was evaluated for the inhibition of 124 I-CCK-8 binding at CCK-B receptorCholecystokinin type B receptorcerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.670nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 (125I-CCK-8) binding to Cholecystokinin type A receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.680nMAssay Description:Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.680nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type A receptor of rat pancreatic membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
Affinity DataIC50: 0.700nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with the Human NPY-Y5 cDNA (compound prepared by para...More data for this Ligand-Target Pair
Affinity DataIC50: 0.710nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with the Human NPY-Y5 cDNA (compound prepared by para...More data for this Ligand-Target Pair
Affinity DataIC50: 0.760nMAssay Description:Inhibition of ACC1 in human HCT116 cells assessed as reduction of [14C]acetate uptake preincubated for 60 mins followed by addition of [14C]acetate a...More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.810nMAssay Description:Compound was evaluated for the inhibition of 124 I-CCK-8 binding at Cholecystokinin type B receptor on guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.830nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.840nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 0.850nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with the Human NPY-Y5 cDNA (compound prepared by para...More data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.890nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.890nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...More data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 0.900nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 0.960nMAssay Description:Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-Co...More data for this Ligand-Target Pair
Affinity DataIC50: 0.960nMAssay Description:Inhibition of recombinant human ACC1 expressed in SF-9 cells preincubated for 60 mins followed by addition of substrate solution containing acetyl-Co...More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 0.960nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
TargetNeprilysin(Rattus norvegicus (Rat))
Novartis Institute For Biomedical Research
Curated by ChEMBL
Novartis Institute For Biomedical Research
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
TargetGastrin/cholecystokinin type B receptor(Homo sapiens (Human))
Fujisawa Pharmaceutical
Curated by ChEMBL
Fujisawa Pharmaceutical
Curated by ChEMBL
Affinity DataIC50: 1nMAssay Description:Inhibition of [125I]-Cholecystokinin-8 binding to Cholecystokinin type B receptor of guinea pig cerebral cortical membranesMore data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 1nMAssay Description:Inhibition of JNK1 (unknown origin) assessed as reduction in phosphorylated ULight-labeled 4EBP1 peptide measured after 1 hr by time-resolved fluores...More data for this Ligand-Target Pair
Affinity DataIC50: 1.10nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with the Human NPY-Y5 cDNA (compound prepared by para...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Displacement of (5-(6-(10H-spiro(1-benzofuran-3,30-pyrrolidin)-10-yl)pyridazin-3-yl)-1,2,4-oxadiazol-3-yl)[3H2]methanol from SCD1 in human liver micr...More data for this Ligand-Target Pair
Affinity DataIC50: 1.20nMAssay Description:Inhibition of 125 I-PYY binding to human Neuropeptide Y receptor type 5More data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 1.30nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.30nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...More data for this Ligand-Target Pair
Target1,3-beta-glucan synthase(Candida albicans (Yeast))
Nippon Roche Research Center
Curated by ChEMBL
Nippon Roche Research Center
Curated by ChEMBL
Affinity DataIC50: 1.40nMAssay Description:In vitro inhibitory activity against Beta glucan synthaseMore data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with Human NPY-Y5 cDNA (compound prepared by manual s...More data for this Ligand-Target Pair
Affinity DataIC50: 1.40nMAssay Description:Inhibitory concentration of total specific binding of [125I]- -PYY to HEK 293 cells transfected with the Human NPY-Y5 cDNA (compound prepared by para...More data for this Ligand-Target Pair