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Found 9919 with Last Name = 'setti' and Initial = 'l'
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427363(CHEMBL2326002)
Affinity DataKi:  0.0800nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427364(CHEMBL2326001)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427365(CHEMBL2326000)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427367(CHEMBL2325998)
Affinity DataKi:  0.100nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427370(CHEMBL2326007)
Affinity DataKi:  0.200nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM19854(CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanom...)
Affinity DataKi:  0.200nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525600(CHEMBL4469412)
Affinity DataKi:  0.200nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410611(CHEMBL414669)
Affinity DataKi:  0.25nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410588(CHEMBL200708)
Affinity DataKi:  0.290nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525603(CHEMBL4528271)
Affinity DataKi:  0.300nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525602(CHEMBL4569479)
Affinity DataKi:  0.400nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410609(CHEMBL198798)
Affinity DataKi:  0.450nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410590(CHEMBL200543)
Affinity DataKi:  0.470nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410587(CHEMBL200602)
Affinity DataKi:  0.480nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM19854(CHEMBL426819 | CRA-013783/L-006235 | N-{1-[(cyanom...)
Affinity DataKi:  0.5nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064172(1-benzylspiro[hexahydropyridine-4,2'-(3',4'-dihydr...)
Affinity DataKi:  0.5nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410607(CHEMBL200744)
Affinity DataKi:  0.570nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410571(CHEMBL200287)
Affinity DataKi:  0.590nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387328(CHEMBL2046649)
Affinity DataKi:  0.600nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50064171(1'-benzylspiro[3,4-dihydro-2H-chromene-2,4'-(hexah...)
Affinity DataKi:  0.620nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410580(CHEMBL435913)
Affinity DataKi:  0.670nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410575(CHEMBL199470)
Affinity DataKi:  0.790nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50142480((E)-7-[(1R,2S,3R)-3-Hydroxy-2-((E)-(S)-3-hydroxy-o...)
Affinity DataKi:  0.800nMAssay Description:Binding affinity was determined against prostanoid EP4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188295((R,S)-4-methyl-2-[3'-(2-piperazin-1-yl-thiazol-4-y...)
Affinity DataKi:  0.800nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410591(CHEMBL200506)
Affinity DataKi:  0.940nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410612(CHEMBL200166)
Affinity DataKi:  0.950nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C epsilon type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427363(CHEMBL2326002)
Affinity DataKi:  1nMAssay Description:Inhibition of PKC epsilon (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525604(CHEMBL4532737)
Affinity DataKi: <1nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427366(CHEMBL2325999)
Affinity DataKi:  1nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427374(CHEMBL2326009)
Affinity DataKi:  1nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1A adrenergic receptor(Rattus norvegicus (Rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  1.05nMAssay Description:Compound was tested for its binding affinity towards Alpha-1A adrenergic receptor using [3H]-prazosin from rat submaxillary glandMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188296((R)-2-{3'-[2-(4-tert-butyl-piperazin-1-yl)-thiazol...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50188297((R,S)-4-methyl-2-{3'-[2-(4-methyl-piperazin-1-yl)-...)
Affinity DataKi:  1.30nMAssay Description:Inhibition of human cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM50036764(1'-benzylspiro[1,2,3,4-tetrahydronaphthalene-2,4'-...)
Affinity DataKi:  1.40nMAssay Description:Compound was tested for its binding affinity towards sigma 1 receptor using [3H]-(+)-pentazocine from guinea pig brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM19855(Balicatib | CHEMBL371064 | N-[1-(cyanomethylcarbam...)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410595(CHEMBL200507)
Affinity DataKi:  1.40nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410572(CHEMBL440035)
Affinity DataKi:  1.5nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410592(CHEMBL200455)
Affinity DataKi:  1.60nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410594(CHEMBL200596)
Affinity DataKi:  1.60nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin E2 receptor EP4 subtype(Homo sapiens (Human))
Roche Palo Alto

Curated by ChEMBL
LigandPNGBDBM50142482(7-{(R)-2-[(E)-(S)-3-Hydroxy-4-(3-trifluoromethyl-p...)
Affinity DataKi:  1.60nMAssay Description:Agonist activity against recombinant prostanoid EP4 receptor stably transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387349(CHEMBL2046644)
Affinity DataKi:  2nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50410606(CHEMBL383186)
Affinity DataKi:  2nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525587(CHEMBL4589844)
Affinity DataKi:  2nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50427382(CHEMBL2326019)
Affinity DataKi:  2nMAssay Description:Inhibition of full-length recombinant PKC theta (unknown origin) using ERMRPRKRQGSVRRRV as substrate after 60 mins by scintillation counting analysis...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Homo sapiens (Human))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM50129070(Acetic acid (2S,3S)-3-((S)-2-benzyloxycarbonylamin...)
Affinity DataKi:  2.20nMAssay Description:Inhibitory activity of the compound was measured against Cathepsin KMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin K(Oryctolagus cuniculus (rabbit))
Celera Genomics

Curated by ChEMBL
LigandPNGBDBM19857(N-{1-[(cyanomethyl)carbamoyl]cyclohexyl}-4-[2-(mor...)
Affinity DataKi:  2.30nMAssay Description:Inhibitory constant against rabbit cathepsin K using Z-Phe-Arg-AMC substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-1B adrenergic receptor(Rattus norvegicus (rat))
University Of Camerino

Curated by ChEMBL
LigandPNGBDBM29568(CHEMBL2 | PRAZOSIN | PRAZOSIN HYDROCHLORIDE | [3H]...)
Affinity DataKi:  2.93nMAssay Description:Compound was tested for its binding affinity towards Alpha-1B adrenergic receptor using [3H]-prazosin from rat liverMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50387330(CHEMBL2046643)
Affinity DataKi:  3nMAssay Description:Inhibition of PKCthetaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525584(CHEMBL4453941)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein kinase C theta type(Homo sapiens (Human))
Vertex Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50525599(CHEMBL4461370)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant full length His tagged PKC theta expressed in baculovirus using ERMRPRKRQGSVRRRV peptide as substrate incubated for 6...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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