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Found 282 with Last Name = 'sheeler' and Initial = 'r'
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  11nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  14nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitotriosidase-1(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  312nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChitotriosidase-1(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataKi:  3.40E+3nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged chitotriosidase expressed in CHO-K1 cells using 4-methylumbelliferyl-beta-D-N,N',N\...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215791(2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-di...)
Affinity DataIC50:  1nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215766(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  2nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215788(CHEMBL399534 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215761(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50:  3nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215793(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215774(CHEMBL246424 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  3nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243685(CHEMBL4084573)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243795(CHEMBL4077644)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215758(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215758(2-((2-aminopyridin-4-yl)methylamino)-N-(2,2-difluo...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215759(CHEMBL247423 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50:  4nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215773(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase B-raf(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215791(2-((2-acetamidopyridin-4-yl)methylamino)-N-(2,2-di...)
Affinity DataIC50:  5nMAssay Description:Inhibition of b-RafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215761(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215775(1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243799(CHEMBL4077482)
Affinity DataIC50:  5.40nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243685(CHEMBL4084573)
Affinity DataIC50:  6.20nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215789(1-(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50:  7nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetVascular endothelial growth factor receptor 2(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215770(1-(5-((5-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)ca...)
Affinity DataIC50:  7nMAssay Description:Inhibition of VEGFR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215782(CHEMBL398052 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  8nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243746(CHEMBL4068944)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243760(CHEMBL4082060)
Affinity DataIC50:  8nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243746(CHEMBL4068944)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243760(CHEMBL4082060)
Affinity DataIC50:  8.70nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215798(CHEMBL395700 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  9nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243795(CHEMBL4077644)
Affinity DataIC50:  9.70nMAssay Description:Inhibition of [3H]WIN-35428 binding to the dopamine transporterMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215777(4-((4-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  11nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243799(CHEMBL4077482)
Affinity DataIC50:  11nMAssay Description:Inhibition of [3H]GBR-12935 binding to the dopamine transporter.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215787(4-((5-((2,2,3,3-tetrafluoro-2,3-dihydrobenzo[b][1,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215776(CHEMBL247591 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215768(1-methyl-3-(5-((1-methyl-4-((2,2,3,3-tetrafluoro-2...)
Affinity DataIC50:  12nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215772(CHEMBL248860 | N-(2,2-difluorobenzo[d][1,3]dioxol-...)
Affinity DataIC50:  13nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataIC50:  14nMAssay Description:Inhibition of human recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-alpha serine/threonine-protein kinase(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50:  15nMAssay Description:Inhibition of pAktMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215771(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  16nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215763(1-methyl-3-(5-((1-methyl-4-((4-(trifluoromethylthi...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215795(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  17nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439246(CHEMBL2418830)
Affinity DataIC50:  17nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215784(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  18nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215785(4-((2-((2,2-difluorobenzo[d][1,3]dioxol-5-yl)carba...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Mus musculus)
Oncoarendi Therapeutics

Curated by ChEMBL
LigandPNGBDBM50243745(CHEMBL4076989)
Affinity DataIC50:  19nMAssay Description:Inhibition of mouse recombinant full length C-terminal His-tagged acidic mammalian chitinase expressed in CHO-K1 cells using 4-methylumbelliferyl-bet...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215781(2-(pyridin-4-ylmethylamino)-N-(2,2,3,3-tetrafluoro...)
Affinity DataIC50:  19nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
Bayer Research Center

Curated by ChEMBL
LigandPNGBDBM50215790(2-((2-(3-(1H-imidazol-1-yl)propylamino)pyridin-4-y...)
Affinity DataIC50:  20nMAssay Description:Inhibition of human recombinant cKit by FRET assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439247(CHEMBL2418831)
Affinity DataIC50:  21nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetArginase-1(Homo sapiens (Human))
Institutes For Pharmaceutical Discovery

Curated by ChEMBL
LigandPNGBDBM50439245(CHEMBL2418991)
Affinity DataIC50:  22nMAssay Description:Inhibition of human arginase-1 assessed as L-arginine conversion to L-ornithine measured as urea level after 1 hr by colorimetric assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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