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Found 1458 with Last Name = 'shin' and Initial = 'd'
LigandPNGBDBM50403096(CHEMBL2216895)
Affinity DataKi:  0.200nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180206((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  0.280nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180197((2S,3S,4R,5R)-5-(2-chloro-6-(3-iodobenzylamino)-9H...)
Affinity DataKi:  0.380nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180219((2-chloropurin-9-yl)-3,4-dihydroxytetrahydrothiphe...)
Affinity DataKi:  0.400nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403075(CHEMBL2216902)
Affinity DataKi:  0.460nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403074(CHEMBL2216903)
Affinity DataKi:  0.576nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180204((2S,3S,4R,5R)-5-(2-chloro-6-(cyclopropylamino)-9H-...)
Affinity DataKi:  0.670nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180209((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H...)
Affinity DataKi:  0.890nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403100(CHEMBL2216891 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  1.05nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Rattus norvegicus)
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50118812((2S,3S,4R,5R)-3,4-Dihydroxy-5-[6-(3-iodo-benzylami...)
Affinity DataKi:  1.10nMAssay Description:Binding affinity for rat Adenosine A3 receptor in CHO cells using [125I]iodo-AB-MECA More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50403100(CHEMBL2216891 | US8765940, 4-(3,3-dimethyl-6-(4-mo...)
Affinity DataKi:  1.10nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180199((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  1.10nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124797(US8765940, 1-(5,7-difluoro-3-methyl-4-(6'-(4-morph...)
Affinity DataKi:  1.27nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124781(US8765940, 1-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-...)
Affinity DataKi:  1.37nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124778(US8765940, 1-(5,7-difluoro-3-methyl-4-(6'-(4-m...)
Affinity DataKi:  1.49nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124765(US8765940, 1'-(5,7-difluoro-3-methyl-2-(5-meth...)
Affinity DataKi:  1.51nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124764(US8765940, 2-(2,2-dimethyl-4-morpholinyl)-4-(3,3-d...)
Affinity DataKi:  1.52nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124749(US8765940, 1-(4-(3,3-dimethyl-6-(4-morpholinyl)-2,...)
Affinity DataKi:  1.54nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM16047((4S)-4-[(2S)-2-[(2R,4S,5S)-5-[(2S)-2-[(2S)-2-[(4S)...)
Affinity DataKi:  1.60nM ΔG°:  -52.2kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
LigandPNGBDBM124759(US8765940, 1-(7-fluoro-3-methyl-4-(6'-(4-morph...)
Affinity DataKi:  1.62nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180207((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  1.63nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124767(US8765940, 1-(7-fluoro-3-methyl-2-(4-methyl-2-pyri...)
Affinity DataKi:  1.96nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A1(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180210((2S,3S,4R,5R)-5-(2-chloro-6-(cyclopentylamino)-9H-...)
Affinity DataKi:  2nMAssay Description:Displacement of [3H]R-PIA from human adenosine A1 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180198((2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)...)
Affinity DataKi:  2.18nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124766(US8765940, 1-(7-fluoro-3-methyl-2-(2-pyridinyl)-4-...)
Affinity DataKi:  2.22nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180215((2S,3S,4R,5R)-5-(2-chloro-6-(cyclopropylamino)-9H-...)
Affinity DataKi:  2.24nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124799(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.24nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124783(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.30nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124798(US8765940, 1-(5,7-difluoro-3-methyl-4-(6'-(4-morph...)
Affinity DataKi:  2.30nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50403099(CHEMBL2216892)
Affinity DataKi:  2.30nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124743(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.34nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124775(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.36nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124758(US8765940, 1-(5,7-difluoro-3-methyl-4-(6'-(4-morph...)
Affinity DataKi:  2.36nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124676(US8765940, 4-(1-(7-fluoro-3-methyl-2-(2-(methylsul...)
Affinity DataKi:  2.44nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetBeta-secretase 1(Homo sapiens (Human))
University of Illinois At Chicago

LigandPNGBDBM16250(CHEMBL290001 | N-(tert-butoxycarbonyl)-L-valyl-N-[...)
Affinity DataKi:  2.5nM ΔG°:  -51.1kJ/molepH: 4.5 T: 2°CAssay Description:Enzyme activities were assayed by monitoring the hydrolysis of substrate in the presence or absence of inhibitor compounds. The hydrolysis was record...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180203((2S,3S,4R,5R)-5-[2-chloro-6-(2-methyl-benzylamino)...)
Affinity DataKi:  2.5nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124734(US8765940, 3-((4-(3,3-dimethyl-6-(4-morpholinyl)-2...)
Affinity DataKi:  2.68nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124757(US8765940, 1'-(8-chloro-2,3-dimethyl-4-quinoli...)
Affinity DataKi:  2.68nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124779(US8765940, tert-butyl 4-(5,7-difluoro-3-methyl-4-(...)
Affinity DataKi:  2.70nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Eli Lilly

Curated by ChEMBL
LigandPNGBDBM50204261(CHEMBL3969063)
Affinity DataKi:  2.70nMAssay Description:Displacement of [3H]-LY459477 from human mGlu3 receptor expressed in hamster AV12 cell membranes co-expressing human EAAT1 after 90 mins by liquid sc...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124731(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.77nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180208((2S,3S,4R,5R)-5-(2-chloro-6-(methylamino)-9H-purin...)
Affinity DataKi:  2.82nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180210((2S,3S,4R,5R)-5-(2-chloro-6-(cyclopentylamino)-9H-...)
Affinity DataKi:  2.83nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124732(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.87nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM124728(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  2.90nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50403101(CHEMBL2216890)
Affinity DataKi:  2.90nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine receptor A3(Homo sapiens (Human))
Ewha Womans University

Curated by ChEMBL
LigandPNGBDBM50180217((2S,3S,4R,5R)-5-(6-(3-iodobenzylamino)-2-chloro-9H...)
Affinity DataKi:  2.96nMAssay Description:Displacement of [125I]AB-MECA from human adenosine A3 receptor transfected in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM124747(US8765940, 4-(3,3-dimethyl-6-(4-morpholinyl)-2,3-d...)
Affinity DataKi:  3nMpH: 7.0Assay Description:A PI3K Alphascreen assay (PerkinElmer, Waltham, Mass.) was used to measure the activity of a panel of four phosphoinositide 3-kinases: PI3Kα, PI...More data for this Ligand-Target Pair
In DepthDetails US Patent
LigandPNGBDBM50403083(CHEMBL2216850)
Affinity DataKi:  3nMAssay Description:Inhibition of PI3KdeltaMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50396616(CHEMBL2171930 | US8765940, 4-(1-(7-fluoro-3-methyl...)
Affinity DataKi:  3nMAssay Description:Inhibition of PI3Kdelta using phosphatidylinositol-4,5-bisphosphate by ATP bioluminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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