Found 2095 with Last Name = 'shoichet' and Initial = 'bk' TargetHistamine H1 receptor(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataKi: 0.800nMAssay Description:Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 0.930nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR expressed in human recombinant SH-SY5Y cell membranes after 120 minsMore data for this Ligand-Target Pair
3D Structure (crystal)Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 1.5nMAssay Description:Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assayMore data for this Ligand-Target Pair
TargetNeuronal acetylcholine receptor subunit alpha-4/beta-2(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 1.60nMAssay Description:Displacement of [3H]cytisine from alpha4beta2 nAChR expressed in human recombinant SH-SY5Y cell membranes after 120 minsMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 2nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 2.20nMAssay Description:Competitive inhibition of N-terminal His6-tagged KDM4C (1 to 352 residues) (unknown origin) expressed in Escherichia coli Rosetta 2(DE3)pLysS using A...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 2.40nMAssay Description:Displacement of [3H]-5-CT from human 5-HT5A receptor at 1 uM incubated for 2 hr by radioligand binding assayMore data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 2.5nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 3.10nMAssay Description:Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assayMore data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 3.70nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 3.70nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 4nMAssay Description:Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 4.10nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 4.10nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 4.5nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 4.70nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M2(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 4.90nMAssay Description:Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M2 receptor expressed in HEK293T cell membranes after 1 hr by liqu...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 5.60nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 5.90nMAssay Description:This study supports a structure-based approach for GPCR ligand discovery. These new chemotypes may stabilize receptor conformations not explored prev...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 5.90nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 6.20nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
Affinity DataKi: 6.5nMAssay Description:This study supports a structure-based approach for GPCR ligand discovery. These new chemotypes may stabilize receptor conformations not explored prev...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 6.5nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 6.70nMAssay Description:Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assayMore data for this Ligand-Target Pair
Target5-hydroxytryptamine receptor 5A(Homo sapiens (Human))
University Of California
Curated by ChEMBL
University Of California
Curated by ChEMBL
Affinity DataKi: 6.70nMAssay Description:Displacement of [3H]-5-CT from human 5-HT5A receptor at 32 uM incubated for 2 hr by radioligand binding assayMore data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 7.70nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 8.30nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetSigma non-opioid intracellular receptor 1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 10nMAssay Description:Displacement of [3H]-pentazocin from the Sigma1 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 10nMAssay Description:Inhibition of Escherichia coli beta-lactamaseMore data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 12nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 12nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 14nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetDelta-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 17nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 18nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 18nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 19nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetHistamine H1 receptor(Homo sapiens (Human))
University Of California San Francisco
Curated by ChEMBL
University Of California San Francisco
Curated by ChEMBL
Affinity DataKi: 19nMAssay Description:Displacement of [3H]pyrilamine from human HRH1 expressed in HEK cell membranes after 90 mins by scintillation counting methodMore data for this Ligand-Target Pair
Affinity DataKi: 20nMAssay Description:Binding affinity of the compound towards AmpC beta-lactamase binding site from Escherichia coliMore data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 20nMAssay Description:Activity of compound against Muscarinic acetylcholine receptor M1 (CHRM1) by displacement of 3H-QNBMore data for this Ligand-Target Pair
Affinity DataKi: 20nMpH: 7.0Assay Description:Enzyme inhibition assay using AmpC or TEM-1 from escherichia coli.More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 22nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 22nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetKappa-type opioid receptor(Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 23nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMuscarinic acetylcholine receptor M1(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 23nMAssay Description:Displacement of [3H]N-methyl-scopolamine bromide from human recombinant muscarinic M1 receptor expressed in HEK293T cell membranes after 1 hr by liqu...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 25nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetMu-type opioid receptor [N127C](Homo sapiens (Human))
The Regents of The University of California
US Patent
The Regents of The University of California
US Patent
Affinity DataKi: 25nMAssay Description:Each compound was initially tested at 20 μM and was incubated with 3H-DPN at a concentration equal to the Kd (0.4 nM) of the radioligand in _...More data for this Ligand-Target Pair
TargetSigma intracellular receptor 2(Homo sapiens (Human))
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Qbi Covid-19 Research Group (Qcrg)
Curated by ChEMBL
Affinity DataKi: 25nMAssay Description:Displacement of [3H]-DTG from the Sigma2 receptorMore data for this Ligand-Target Pair
Affinity DataKi: 27nMAssay Description:Inhibitory activity against E. coli AmpC beta-lactamase.More data for this Ligand-Target Pair
