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Found 460 with Last Name = 'smirk' and Initial = 'r'
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32522(pyridine amide, 30)
Affinity DataIC50:  0.100nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32520(pyridine amide, 28)
Affinity DataIC50:  1.10nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32521(pyridine amide, 29)
Affinity DataIC50:  1.10nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32527(pyridine amide, 35)
Affinity DataIC50:  1.70nMT: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32523(pyridine amide, 31)
Affinity DataIC50:  2nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32526(pyridine amide, 34)
Affinity DataIC50:  2nMT: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32508(pyridine amide, 23)
Affinity DataIC50:  2.5nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32519(pyridine amide, 27)
Affinity DataIC50:  2.90nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32524(pyridine amide, 32)
Affinity DataIC50:  3.60nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32529(pyridine amide, 37)
Affinity DataIC50:  4.60nMT: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32525(pyridine amide, 33)
Affinity DataIC50:  4.70nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM13592(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
Affinity DataIC50:  5nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32528(pyridine amide, 36)
Affinity DataIC50:  6.5nMT: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439474(CHEMBL2417906)
Affinity DataIC50:  7nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32512(pyridine amide, 6)
Affinity DataIC50:  7.20nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439477(CHEMBL2417903)
Affinity DataIC50:  9nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439475(CHEMBL2417905)
Affinity DataIC50:  11nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439487(CHEMBL2417893)
Affinity DataIC50:  11nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32507(pyridine amide, 22)
Affinity DataIC50:  11nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439486(CHEMBL2417894)
Affinity DataIC50:  13nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439473(CHEMBL2417907)
Affinity DataIC50:  13nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32518(pyridine amide, 9)
Affinity DataIC50:  17nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50377302(CHEMBL255930)
Affinity DataIC50:  20nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50377302(CHEMBL255930)
Affinity DataIC50:  20nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063315(CHEMBL3398446)
Affinity DataIC50:  20nMAssay Description:Binding affinity to PPARalpha (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32506(pyridine amide, 21)
Affinity DataIC50:  21nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32500(pyridine amide, 15)
Affinity DataIC50:  22nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439488(CHEMBL2417911)
Affinity DataIC50:  23nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439484(CHEMBL2417896)
Affinity DataIC50:  34nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM13592(2-{2-[(4-carbamimidoylphenyl)carbamoyl]-6-methoxyp...)
Affinity DataIC50:  35nMAssay Description:Inhibition of human F10a using S-2222 as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32499(pyridine amide, 8)
Affinity DataIC50:  35nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063311(CHEMBL3398444)
Affinity DataIC50:  40nMAssay Description:Binding affinity to PPARalpha (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor alpha(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063311(CHEMBL3398444)
Affinity DataIC50:  40nMAssay Description:Binding affinity to PPARalpha (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063315(CHEMBL3398446)
Affinity DataIC50:  40nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063313(CHEMBL3398454)
Affinity DataIC50:  50nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439478(CHEMBL2417902)
Affinity DataIC50:  51nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439472(CHEMBL2417908)
Affinity DataIC50:  60nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32513(pyridine amide, 7)
Affinity DataIC50:  79nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063089(CHEMBL3398443)
Affinity DataIC50:  80nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063311(CHEMBL3398444)
Affinity DataIC50:  80nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063311(CHEMBL3398444)
Affinity DataIC50:  80nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063089(CHEMBL3398443)
Affinity DataIC50:  80nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063099(CHEMBL3398459)
Affinity DataIC50:  90nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor X(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439475(CHEMBL2417905)
Affinity DataIC50:  100nMAssay Description:Inhibition of human F10a using S-2222 as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439479(CHEMBL2417901)
Affinity DataIC50:  101nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target11-beta-hydroxysteroid dehydrogenase 1 [23-292,A23S,F278E](Homo sapiens (Human))
Bristol-Myers Squibb

LigandPNGBDBM32501(pyridine amide, 16)
Affinity DataIC50:  106nMpH: 6.5 T: 2°CAssay Description:11beta-HSD1 microsomes isolated from HEK 293 cells over-expressing human 11beta-HSD1 were incubated with the substrate cortisone and cofactor NADPH a...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPeroxisome proliferator-activated receptor gamma(Homo sapiens (Human))
Bristol-Myers Squibb Research And Development (R & D)

Curated by ChEMBL
LigandPNGBDBM50063316(CHEMBL3398447)
Affinity DataIC50:  110nMAssay Description:Binding affinity to PPARgamma (unknown origin) using fluorescein-tagged dual PPARalpha/gamma activator by homogeneous fluorescence polarization bindi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439485(CHEMBL2417895)
Affinity DataIC50:  111nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCoagulation factor VII(Homo sapiens (Human))
Bristol-Myers Squibb Research & Development

Curated by ChEMBL
LigandPNGBDBM50439483(CHEMBL2417897)
Affinity DataIC50:  113nMAssay Description:Inhibition of human F7a using D-Ile-Pro-Arg-AFC as substrate after 3 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHexokinase-4(Homo sapiens (Human))
Bristol Myers Squibb

Curated by ChEMBL
LigandPNGBDBM50585812(CHEMBL5091943)
Affinity DataIC50:  122nMAssay Description:Displacement of fluorescent labeled derivative from recombinant human hepatic glucokinase incubated for 30 mins in presence of 12 mM glucose by fluor...More data for this Ligand-Target Pair
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