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Found 163 with Last Name = 'souness' and Initial = 'je'
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM14361((R,S)-Rolipram | 4-(3-cyclopentyloxy-4-methoxy-phe...)
Affinity DataKi:  4.5nMAssay Description:Inhibition of rolipram binding to Phosphodiesterase 4More data for this Ligand-Target Pair
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataKi:  60nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216308(CHEMBL297296)
Affinity DataKi:  200nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216314(CHEMBL49351)
Affinity DataKi:  2.40E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216313(CHEMBL300959)
Affinity DataKi:  2.60E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216322(CHEMBL301351)
Affinity DataKi:  2.80E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216320(CHEMBL430948)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216309(CHEMBL301366)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216312(CHEMBL296824)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216311(CHEMBL300427)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216310(CHEMBL52224)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216306(CHEMBL48221)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50216307(CHEMBL300038)
Affinity DataKi: >3.70E+3nMAssay Description:Displacement of [3H]rolipram binding to guinea pig brain membraneMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473625(CHEMBL69319)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041849(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(3,5-dichloro-pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041849(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(3,5-dichloro-pyr...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM14775(3-(cyclopentyloxy)-N-(3,5-dichloropyridin-4-yl)-4-...)
Affinity DataIC50:  1nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473629(CHEMBL70053 | RPR-238677)
Affinity DataIC50:  2nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041853(3-Cyclopentyloxy-N-(3,5-dichloro-1-oxy-pyridin-4-y...)
Affinity DataIC50:  2nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473626(CHEMBL71572 | RPR-239938)
Affinity DataIC50:  3nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473627(CHEMBL308203 | RPR-239939)
Affinity DataIC50:  3.5nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473623(CHEMBL309802 | RPR-238778)
Affinity DataIC50:  4nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473629(CHEMBL70053 | RPR-238677)
Affinity DataIC50:  4nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcAMP-specific 3',5'-cyclic phosphodiesterase 4A/4B/4C/4D(Homo sapiens (Human))
Rh£Ne-Poulenc Rorer Central Research

Curated by ChEMBL
LigandPNGBDBM50064858((R)-4-(2-(3-(cyclopentyloxy)-4-methoxyphenyl)-2-ph...)
Affinity DataIC50:  4.5nMAssay Description:Inhibition of guinea pig macrophage Phosphodiesterase 4More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219254(CHEMBL347592)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473632(CHEMBL71425 | RPR-239457)
Affinity DataIC50:  5nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473626(CHEMBL71572 | RPR-239938)
Affinity DataIC50:  6nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473627(CHEMBL308203 | RPR-239939)
Affinity DataIC50:  6nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473625(CHEMBL69319)
Affinity DataIC50:  6nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041831(3-Cyclopentyloxy-N-(3,5-dibromo-pyridin-4-yl)-4-me...)
Affinity DataIC50:  7nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219252(CHEMBL159932)
Affinity DataIC50:  7nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041846(3-Butoxy-N-(3,5-dichloro-pyridin-4-yl)-4-methoxy-b...)
Affinity DataIC50:  8nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473623(CHEMBL309802 | RPR-238778)
Affinity DataIC50:  9nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte THP-1 cell linesMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219253(CHEMBL161197)
Affinity DataIC50:  9nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041886(3-(Bicyclo[2.2.1]hept-2-yloxy)-N-(2,6-dichloro-phe...)
Affinity DataIC50:  10nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473622(CHEMBL70705 | RPR-239497)
Affinity DataIC50:  12nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041847(CHEMBL295976 | N-(3-Chloro-pyridin-4-yl)-3-cyclope...)
Affinity DataIC50:  16nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50219251(CHEMBL423071)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity against p38 kinase (40 ng/well) was determined in mouseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041875(3-Cyclopentyloxy-N-(3,5-dichloro-2,6-difluoro-pyri...)
Affinity DataIC50:  20nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041838(3-(cyclopentyloxy)-N-(2,6-dichlorophenyl)-4-methox...)
Affinity DataIC50:  23nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132421(3-[1-(1H-Pyrrol-2-yl)-meth-(Z)-ylidene]-5-(thiophe...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132420(3-((1H-pyrrol-2-yl)methylene)-5-(pyridin-3-yl)indo...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein kinase JAK3(Homo sapiens (Human))
Aventis Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50132427(5-Pyridin-3-yl-3-[1-(1H-pyrrol-2-yl)-meth-(Z)-ylid...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity against Janus Kinase 3 protein tyrosine kinase.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041869(3-Cyclopentyloxy-N-(3,5-dimethyl-pyridin-4-yl)-4-m...)
Affinity DataIC50:  35nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473630(CHEMBL67911 | RPR-235455)
Affinity DataIC50:  47nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041824(3-Cyclohexyloxy-N-(3,5-dichloro-pyridin-4-yl)-4-me...)
Affinity DataIC50:  50nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473631(CHEMBL308003 | RPR-200765A)
Affinity DataIC50:  60nMAssay Description:Inhibition of p38-related TNF alpha release by human monocyte cell line (THP-1)More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 13(Mus musculus)
Aventis Pharma

Curated by ChEMBL
LigandPNGBDBM50473628(CHEMBL307604 | RPR-235315)
Affinity DataIC50:  62nMAssay Description:Inhibition of murine Mitogen-activated protein kinase p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041879(3-Butoxy-N-(3,5-dibromo-pyridin-4-yl)-4-methoxy-be...)
Affinity DataIC50:  70nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target3',5'-cyclic-AMP phosphodiesterase(Sus scrofa)
RhôNe-Poulenc Rorer

Curated by ChEMBL
LigandPNGBDBM50041844(3-(cyclopentyloxy)-N-(2,6-difluorophenyl)-4-methox...)
Affinity DataIC50:  70nMAssay Description:Inhibitory potency against pig aortic PDE IVMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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