Reaction Details Report a problem with these data
Target
Mitogen-activated protein kinase 13
Ligand
BDBM50219253
Substrate
n/a
Meas. Tech.
ChEMBL_124321 (CHEMBL732629)
IC50
9.0±n/a nM
Citation
 Collis, AJ; Foster, ML; Halley, F; Maslen, C; McLay, IM; Page, KM; Redford, EJ; Souness, JE; Wilsher, NE RPR203494 a pyrimidine analogue of the p38 inhibitor RPR200765A with an improved in vitro potency. Bioorg Med Chem Lett 11:693-6 (2001) [PubMed]  Article 
Target
Name:
Mitogen-activated protein kinase 13
Synonyms:
MAP kinase 13 | MAP kinase p38 delta | MAPK 13 | MK13_MOUSE | Mapk13 | Mitogen-activated protein kinase 13 | Mitogen-activated protein kinase p38 delta | Serk4 | Stress-activated protein kinase 4
Type:
PROTEIN
Mol. Mass.:
42081.17
Organism:
Mus musculus
Description:
ChEMBL_105000
Residue:
366
Sequence:
MSLTRKRGFYKQDINKTAWELPKTYLAPAHVGSGAYGAVCSAIDKRTGEKVAIKKLSRPFQSEIFAKRAYRELLLLKHMHHENVIGLLDVFTPASSLRSFHDFYLVMPFMQTDLQKIMGMEFSEDKVQYLVYQMLKGLKYIHSAGIVHRDLKPGNLAVNEDCELKILDFGLARHTDTEMTGYVVTRWYRAPEVILSWMHYNQTVDIWSVGCIMAEMLTGKTLFKGKDYLDQLTQILKVTGVPGAEFVQKLKDKAAKSYIQSLPQSPKKDFTQLFPRASPQAADLLDKMLELDVDKRLTAAQALAHPFFEPFRDPEEETEAQQPFDDALEHEKLSVDEWKQHIYKEISNFSPIARKDSRRRSGMKLQ
  
Inhibitor
Name:
BDBM50219253
Synonyms:
CHEMBL161197
Type:
Small organic molecule
Emp. Form.:
C26H29FN6O4
Mol. Mass.:
508.5447
SMILES:
C[C@@]1(CO[C@@H](OC1)c1nc(c([nH]1)-c1ccnc(NC2CC2)n1)-c1ccc(F)cc1)C(=O)N1CCOCC1 |wU:4.7,1.0,wD:1.33,(10.32,.96,;9.56,-.37,;8.65,.88,;7.12,.72,;6.51,-.7,;7.4,-1.94,;8.93,-1.78,;4.98,-.86,;4.21,-2.19,;2.69,-1.87,;2.53,-.35,;3.94,.28,;1.2,.42,;1.2,1.96,;-.14,2.73,;-1.47,1.96,;-1.47,.42,;-2.81,-.35,;-4.14,.42,;-5.64,.02,;-4.73,1.97,;-.14,-.35,;1.55,-2.92,;1.87,-4.41,;.75,-5.43,;-.72,-4.97,;-1.87,-6,;-1.05,-3.46,;.09,-2.43,;10.89,-1.14,;10.89,-2.68,;12.22,-.37,;13.55,-1.15,;14.88,-.38,;14.89,1.16,;13.56,1.93,;12.21,1.17,)|
Structure:
Search PDB for entries with ligand similarity: