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Found 46 with Last Name = 'strand' and Initial = 'j'
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  80nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478156(CHEMBL258936)
Affinity DataIC50:  100nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478156(CHEMBL258936)
Affinity DataIC50:  110nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16755(Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...)
Affinity DataIC50:  110nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  130nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  160nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478159(CHEMBL261773)
Affinity DataIC50:  180nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478156(CHEMBL258936)
Affinity DataIC50:  190nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478159(CHEMBL261773)
Affinity DataIC50:  200nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378795(CHEMBL1215473)
Affinity DataIC50:  210nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50:  240nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478156(CHEMBL258936)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  300nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16755(Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...)
Affinity DataIC50:  340nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50370476(Combivir | ZIDOVUDINE TRIPHOSPHATE)
Affinity DataIC50:  420nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  550nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50:  600nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50:  680nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM72759(2-methyl-3-[(4-pyridin-2-ylpiperazin-1-yl)methyl]-...)
Affinity DataIC50:  700nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50:  900nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478157(Carbovir-Triphosphate)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  3.20E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50:  3.50E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 1(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50:  3.70E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16755(Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...)
Affinity DataIC50:  5.90E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50:  8.20E+3nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50:  1.29E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378796(CHEMBL1215544)
Affinity DataIC50:  1.30E+4nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50:  1.94E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378797(CHEMBL1215545)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50:  3.02E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16752(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-(...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16753(2-[2-(2-chlorophenyl)-5-[4-(4-acetylphenoxy)phenyl...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBeta-secretase 2(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16754(2-[2-(adamantan-1-yl)-5-phenyl-1H-pyrrol-1-yl]-N-[...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16755(Acylguanidine, 10d | N-[(1Z)-amino[(3-hydroxypropy...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPepsin A-4(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50: >5.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCathepsin D(Homo sapiens (Human))
Wyeth Research

LigandPNGBDBM16751((N-(diaminomethylene)-2,4-diphenyl-1H-pyrrole-1-ac...)
Affinity DataIC50:  6.00E+4nMpH: 4.5 T: 2°CAssay Description:A homogenous, continuous fluorescence resonance energy transfer (FRET) assay was used to assess compound inhibition of enzyme based on the cleavage o...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50027028(2-(piperazin-1-yl)nicotinamide | 2-Piperazin-1-yl-...)
Affinity DataIC50:  1.02E+5nMAssay Description:Inhibition of acidic mammalian chitinase after 60 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50027028(2-(piperazin-1-yl)nicotinamide | 2-Piperazin-1-yl-...)
Affinity DataKd:  1.41E+5nMAssay Description:Binding affinity to biotinylated-acidic mammalian chitinaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378796(CHEMBL1215544)
Affinity DataKd:  1.70E+4nMAssay Description:Binding affinity to biotinylated-acidic mammalian chitinaseMore data for this Ligand-Target Pair
TargetAcidic mammalian chitinase(Homo sapiens (Human))
Pfizer

Curated by ChEMBL
LigandPNGBDBM50378795(CHEMBL1215473)
Affinity DataKd:  1.69E+3nMAssay Description:Binding affinity to biotinylated-acidic mammalian chitinaseMore data for this Ligand-Target Pair