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Found 7 Enz. Inhib. hit(s) with Target = 'Reverse transcriptase' and Ligand = 'BDBM50478158'
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  550nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type LAI by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  1.20E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  1.30E+3nMAssay Description:Inhibition of HIV1 LAI reverse transcriptase wild type in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  4.00E+3nMAssay Description:Inhibition of HIV1 pNL4-3 reverse transcriptase wild type pNL4-3 in presence of 5 mM ATP by heteropolymeric DNA polymerase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli using calf thymus DNA substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataKd:  2.30E+4nMAssay Description:Binding affinity to HIV1 wild type reverse transcriptase p66/p51 expressed in Escherichia coli assessed as incorporation of drug to DNA by gel electr...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReverse transcriptase(Human immunodeficiency virus 1)
Emory University

Curated by ChEMBL
LigandPNGBDBM50478158(Tenofovir diphospahte | tenofovir diphosphate)
Affinity DataKd:  1.65E+4nMAssay Description:Binding affinity to wild type HIV1 reverse transcriptase by pre-steady state kinetics studyMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed