Compile Data Set for Download or QSAR
maximum 50k data
Found 220 with Last Name = 'teske' and Initial = 'ka'
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50241662(CHEMBL4104741)
Affinity DataIC50:  7nMAssay Description:Inhibition of GST-tagged EED (unknown origin) after 1 hr by OG(488) as probe-based TR-FRET analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522394(CHEMBL4472296)
Affinity DataIC50:  9nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50011478(ITRAZOLE)
Affinity DataIC50:  40nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522382(CHEMBL4450586)
Affinity DataIC50:  89nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 1(Homo sapiens)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282169(CHEBI:3507 | Cefsulodin)
Affinity DataIC50:  98nMAssay Description:Inhibition of L3MBTL1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522397(CHEMBL4440172)
Affinity DataIC50:  110nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522400(CHEMBL4562342)
Affinity DataIC50:  140nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50181473(4-(4-(4-(4-(((3R,5R)-5-((1H-1,2,4-triazol-1-yl)met...)
Affinity DataIC50:  150nMAssay Description:Inhibition of CYP3A4 in human liver microsomes by LC-MS/MS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522393(CHEMBL4572598)
Affinity DataIC50:  160nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522373(CHEMBL4472335)
Affinity DataIC50:  190nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522396(CHEMBL4447164)
Affinity DataIC50:  190nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522372(CHEMBL4473575)
Affinity DataIC50:  210nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522380(CHEMBL4562519)
Affinity DataIC50:  260nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLethal(3)malignant brain tumor-like protein 1(Homo sapiens)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM60983((E)-2-(3,4-dihydroxybenzoyl)-3-(4-hydroxy-3-iodo-5...)
Affinity DataIC50:  282nMAssay Description:Inhibition of L3MBTL1 (unknown origin) by AlphaScreen assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522391(CHEMBL4462158)
Affinity DataIC50:  310nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHistone-lysine N-methyltransferase 2A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50164787(CHEMBL3798088)
Affinity DataIC50:  320nMAssay Description:Inhibition of recombinant SUMO-tagged MLL1 (unknown origin) by histone methyl transferase assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522379(CHEMBL4583477)
Affinity DataIC50:  390nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein argonaute-2(Homo sapiens)TBA
LigandPNGBDBM50608342(CHEMBL4439201)
Affinity DataIC50:  450nMAssay Description:Inhibition of AGO2 (unknown origin)More data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetProtein argonaute-2(Homo sapiens)TBA
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50:  690nMAssay Description:Inhibition of AGO2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522374(CHEMBL4471156)
Affinity DataIC50:  920nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein argonaute-2(Homo sapiens)TBA
LigandPNGBDBM81264(5-(2-aminoethyl)benzene-1,2,4-triol;hydrobromide |...)
Affinity DataIC50:  1.61E+3nMAssay Description:Inhibition of AGO2 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282161(CHEMBL4175336)
Affinity DataIC50:  1.65E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282163(CHEMBL4171889)
Affinity DataIC50:  1.74E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522385(CHEMBL4455409)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50139645(CHEBI:47828 | CHEMBL3544529)
Affinity DataIC50:  2.29E+3nMAssay Description:Antagonist activity against VDR-LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of VDR agonist LG190178-induced SRC2-3 coac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProtein lin-28 homolog A(Homo sapiens)TBA
LigandPNGBDBM367675(N,N,N′,N′-Tetrakis(2-pyridinylmethyl)-...)
Affinity DataIC50:  2.50E+3nMAssay Description:Inhibition of LIN28A (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetVitamin D3 receptor(Homo sapiens (Human))
University Of Wisconsin

Curated by ChEMBL
LigandPNGBDBM50139647(CHEMBL3764957)
Affinity DataIC50:  2.86E+3nMAssay Description:Antagonist activity against VDR-LBD (unknown origin) expressed in Escherichia coli assessed as inhibition of VDR agonist LG190178-induced SRC2-3 coac...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522386(CHEMBL4543531)
Affinity DataIC50:  3.00E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPolycomb protein EED(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50282157(CHEMBL4161291)
Affinity DataIC50:  3.87E+3nMAssay Description:Inhibition of full length N-terminal His-tagged EED (unknown origin) expressed in Rosetta2 BL21(DE3)pLysS cells after 30 mins by 3-FAM labelled fluor...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522375(CHEMBL4473720)
Affinity DataIC50:  3.90E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein lin-28 homolog A(Homo sapiens)TBA
LigandPNGBDBM50608339(CHEMBL4556019)
Affinity DataIC50:  4.03E+3nMAssay Description:Inhibition of LIN28A (unknown origin) by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522377(CHEMBL4571341)
Affinity DataIC50:  4.30E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetButyrophilin subfamily 3 member A1(Homo sapiens (Human))
Western Michigan University

Curated by ChEMBL
LigandPNGBDBM50236893(CHEBI:15664 | CHEMBL145233)
Affinity DataIC50:  4.56E+3nMAssay Description:Displacement of GDP-BODIPY from C-terminal 6His-tagged BTN3A1 R499A mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 60...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522399(CHEMBL4456292)
Affinity DataIC50:  5.70E+3nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProtein lin-28 homolog A(Homo sapiens)TBA
LigandPNGBDBM50608340(CHEMBL1314668)
Affinity DataIC50:  7.00E+3nMAssay Description:Inhibition of LIN28A (unknown origin) by FRET assayMore data for this Ligand-Target Pair
Ligand Info
In DepthDetails PubMed
TargetButyrophilin subfamily 3 member A1(Homo sapiens (Human))
Western Michigan University

Curated by ChEMBL
LigandPNGBDBM50516697(CHEMBL4302450)
Affinity DataIC50:  7.87E+3nMAssay Description:Displacement of GDP-BODIPY from C-terminal 6His-tagged BTN3A1 full interaction domain (unknown origin) expressed in Escherichia coli BL21 (DE) measur...More data for this Ligand-Target Pair
TargetButyrophilin subfamily 3 member A1(Homo sapiens (Human))
Western Michigan University

Curated by ChEMBL
LigandPNGBDBM50516697(CHEMBL4302450)
Affinity DataIC50:  7.87E+3nMAssay Description:Displacement of GDP-BODIPY from C-terminal 6His-tagged BTN3A1 B30.2 domain (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 60...More data for this Ligand-Target Pair
TargetProtein lin-28 homolog A(Homo sapiens)TBA
LigandPNGBDBM50468906(CHEMBL1733963)
Affinity DataIC50:  8.00E+3nMAssay Description:Inhibition of LIN28A (unknown origin) by FRET assayMore data for this Ligand-Target Pair
In DepthDetails PubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50179360(CHEMBL3040216)
Affinity DataIC50:  8.10E+3nMAssay Description:Inhibition of Cbx7 (unknown origin) using FITC-labeled SETDB1-K1170me3 peptide as probe by fluorescence polarization assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetButyrophilin subfamily 3 member A1(Homo sapiens (Human))
Western Michigan University

Curated by ChEMBL
LigandPNGBDBM50236893(CHEBI:15664 | CHEMBL145233)
Affinity DataIC50:  9.64E+3nMAssay Description:Displacement of GDP-BODIPY from C-terminal 6His-tagged BTN3A1 W421A mutant (unknown origin) expressed in Escherichia coli BL21 (DE) measured after 60...More data for this Ligand-Target Pair
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522371(CHEMBL4565311)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522392(CHEMBL4530520)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522395(CHEMBL4553424)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522376(CHEMBL4448878)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522378(CHEMBL4464304)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522401(CHEMBL4541851)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522398(CHEMBL4551142)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A(Homo sapiens (Human))
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50058655(1,1',1'',1'''-[disulfanediylbis(carbonothioylnitri...)
Affinity DataIC50:  1.00E+4nMAssay Description:Inhibition of JARID1A PHD finger domain (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522381(CHEMBL4466705)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetSmoothened homolog(Mus musculus)
University Of Connecticut

Curated by ChEMBL
LigandPNGBDBM50522383(CHEMBL4556073)
Affinity DataIC50: >1.00E+4nMAssay Description:Inhibition of smo-mediated hedgehog signaling pathway in mouse ASZ001 cells assessed as decrease in Gli1 mRNA expression after 48 hrs by qPCR methodMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Displayed 1 to 50 (of 220 total ) | Next | Last >>
Jump to: