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Found 1239 with Last Name = 'tian' and Initial = 'g'
TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50367032(COFORMYCIN)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM22925((8R)-3-[(2R,4S,5R)-4-hydroxy-5-(hydroxymethyl)oxol...)
Affinity DataKi:  0.100nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM11639(4-[5-(4-methylphenyl)-3-(trifluoromethyl)-1H-pyraz...)
Affinity DataKi:  0.470nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM28393((+)-EHNA | (2S,3R)-3-(6-amino-9H-purin-9-yl)nonan-...)
Affinity DataKi:  2nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50566910(CHEMBL4870569)
Affinity DataKi:  3nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50099385((1S,2R,6S,7R)-4-[4-(4-Pyrimidin-2-yl-piperazin-1-y...)
Affinity DataKi:  5.80nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50001859((buspirone) 8-[4-(4-Pyrimidin-2-yl-piperazin-1-yl)...)
Affinity DataKi:  8.90nMAssay Description:Agonist activity at 5HT1A receptor (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50566912(CHEMBL4859571)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50566901(CHEMBL4865464)
Affinity DataKi:  12nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50566913(CHEMBL4857474)
Affinity DataKi:  19nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50566911(CHEMBL4868446)
Affinity DataKi:  32nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50072064(5-Chloro-3-(4-methanesulfonyl-phenyl)-6''-methyl-[...)
Affinity DataKi:  69nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50404651(CHEMBL1555103)
Affinity DataKi:  80nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Janssen Research And Development

Curated by ChEMBL
LigandPNGBDBM50566900(CHEMBL4862802)
Affinity DataKi:  114nMAssay Description:Inhibition of human recombinant COX-2 using arachidonic acid as substrate preincubated for 60 mins followed by substrate addition for 2 secs by ADPH ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50404652(CHEMBL2114367)
Affinity DataKi:  122nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50373038(CHEMBL407567)
Affinity DataKi:  150nMAssay Description:Inhibition of CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50301283((R)-2-benzyl-5-nitro-4-oxopentanoic acid | CHEMBL5...)
Affinity DataKi:  160nMAssay Description:Inhibition of Carboxypeptidase A assessed as amount of Cl-CPL consumed by UV spectrometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50301281((+/-)-2-benzyl-5,5,5-trifluoro-4-oxopentanoic acid...)
Affinity DataKi:  200nMAssay Description:Inhibition of Carboxypeptidase A assessed as amount of Cl-CPL consumed by UV spectrometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAcetylcholinesterase(Electrophorus electricus (Electric eel))
Henan University

Curated by ChEMBL
LigandPNGBDBM50443692(CHEMBL3093837)
Affinity DataKi:  386nMAssay Description:Mixed-type inhibition of electric eel AChE using acetylthiocholine chloride as substrate incubated for 15 mins prior to substrate addition by Linewea...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50301282((+/-)-2-benzyl-5-nitro-4-oxopentanoic acid | CHEMB...)
Affinity DataKi:  430nMAssay Description:Inhibition of Carboxypeptidase A assessed as amount of Cl-CPL consumed by UV spectrometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50373036(CHEMBL259621)
Affinity DataKi:  450nMAssay Description:Inhibition of CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50034908((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Affinity DataKi:  500nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAdenosine deaminase(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50034908((2R,3S)-3-((R)-6-Amino-purin-9-yl)-nonan-2-ol | (2...)
Affinity DataKi:  500nMAssay Description:Compound was evaluated for the inhibition of adenosine deaminaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50373037(CHEMBL261332)
Affinity DataKi:  790nMAssay Description:Inhibition of CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50373039(CHEMBL407566)
Affinity DataKi:  2.08E+3nMAssay Description:Inhibition of CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50301280((+/-)-2-benzyl-5-bromo-4-oxopentanoic acid | CHEMB...)
Affinity DataKi:  1.50E+4nMAssay Description:Inhibition of Carboxypeptidase A assessed as amount of Cl-CPL consumed by UV spectrometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50301284((S)-2-benzyl-5-nitro-4-oxopentanoic acid | CHEMBL5...)
Affinity DataKi:  3.10E+4nMAssay Description:Inhibition of Carboxypeptidase A assessed as amount of Cl-CPL consumed by UV spectrometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50373035(CHEMBL259221)
Affinity DataKi:  6.26E+4nMAssay Description:Inhibition of CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50373037(CHEMBL261332)
Affinity DataKi:  6.80E+4nMAssay Description:Inhibition of CPAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCarboxypeptidase A1(Homo sapiens (Human))
Yanbian University

Curated by ChEMBL
LigandPNGBDBM50301279((+/-)-2-benzyl-4-oxopentanoic acid | CHEMBL568460)
Affinity DataKi:  2.07E+5nMAssay Description:Inhibition of Carboxypeptidase A assessed as amount of Cl-CPL consumed by UV spectrometerMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319696(6-(2-(4-(2-fluorobenzo[b]thiophen-4-yl)piperazin-1...)
Affinity DataIC50:  0.0920nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50:  0.200nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319702(5-(2-(4-(2-fluorobenzo[b]thiophen-4-yl)piperazin-1...)
Affinity DataIC50:  0.219nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319695(7-(2-(4-(2-fluorobenzo[b]thiophen-4-yl)piperazin-1...)
Affinity DataIC50:  0.242nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319701(6-(4-(4-(2-fluorobenzo[b]thiophen-4-yl)piperazin-1...)
Affinity DataIC50:  0.320nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319626(5-(2-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)ethy...)
Affinity DataIC50:  0.384nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of TRKA GS95R mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581522(CHEMBL5075273)
Affinity DataIC50:  0.400nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319692(7-(2-(4-(2-fluorobenzo[b]thiophen-4-yl)piperazin-1...)
Affinity DataIC50:  0.480nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581524(CHEMBL5078405)
Affinity DataIC50:  0.5nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50525064(CHEMBL4455533)
Affinity DataIC50:  0.540nMAssay Description:Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 2A(Homo sapiens (Human))
Shanghai Institute Of Materia Medica

Curated by ChEMBL
LigandPNGBDBM50464898(CHEMBL4287980)
Affinity DataIC50:  0.600nMAssay Description:Antagonist activity at 5-HT2A receptor (unknown origin) after 10 mins by calcium 5 dye based FLIPR assayMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50525060(CHEMBL4462192)
Affinity DataIC50:  0.620nMAssay Description:Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc...More data for this Ligand-Target Pair
TargetD(2) dopamine receptor(Homo sapiens (Human))
Shanghai Institute of Material Medica, Chinese Academy of Sciences

US Patent
LigandPNGBDBM319700(6-(4-(4-(benzo[b]thiophen-4-yl)piperazin-1-yl)buty...)
Affinity DataIC50:  0.672nMAssay Description:The D2 receptor agonism activity test (The agonism activity of test compounds on D2 receptor expressing human recombinant D2 receptor in HEK293 cells...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581525(CHEMBL5088000)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of wildtype TRKA (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 40 mi...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50525071(CHEMBL4474634)
Affinity DataIC50:  0.790nMAssay Description:Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetcGMP-specific 3',5'-cyclic phosphodiesterase(Homo sapiens (Human))
Chinese Academy Of Sciences

Curated by ChEMBL
LigandPNGBDBM50525067(CHEMBL4444940)
Affinity DataIC50:  0.830nMAssay Description:Inhibition of N-terminal GST-tagged human PDE5A1 expressed in baculovirus infected sf9 cells using [3H]cGMP as substrate measured after 30 mins by sc...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetHigh affinity nerve growth factor receptor(Homo sapiens (Human))
Central China Normal University

Curated by ChEMBL
LigandPNGBDBM50581523(CHEMBL5092943)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of TRKA G667C mutant (unknown origin) preincubated for 30 mins followed by biotinylated TK-peptide substrate addition and measured after 4...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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