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Found 418 with Last Name = 'tung' and Initial = 'r'
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4690((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00000600nMAssay Description:Displacement of [3H]GW0385 from HIV1 proteaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0000150nMAssay Description:Displacement of [3H]GW0385 from HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM4685((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.0000150nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0000570nMAssay Description:Inhibition of HIV1 protease by fluorescent peptide substrate based assayMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM8125((3R,3aS,6aR)-hexahydrofuro[2,3-b]furan-3-yl N-[(2S...)
Affinity DataKi:  0.00147nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM50479982(Aptivus | CHEBI:63628 | Tipranavir | U-140690 | US...)
Affinity DataKi:  0.00800nMAssay Description:Inhibition of HIV1 protease by fluorescent peptide substrate based assayMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108297(US8604046, 77)
Affinity DataKi:  0.00800nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM518((3S,4aS,8aS)-N-tert-butyl-2-[(2R,3R)-2-hydroxy-3-[...)
Affinity DataKi:  0.0100nM ΔG°:  -62.8kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM520(1,3-thiazol-5-ylmethyl N-[(2S,3S,5S)-3-hydroxy-5-[...)
Affinity DataKi:  0.0200nM ΔG°:  -61.1kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108281(US8604046, 61)
Affinity DataKi:  0.0300nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetProtease(Human immunodeficiency virus 1 (HIV-1))
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0360nMAssay Description:Inhibition of HIV1 proteaseMore data for this Ligand-Target Pair
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108315(US8604046, 95)
Affinity DataKi:  0.0400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM519((2S)-N-[(2S,3R)-4-[(3S,4aS,8aS)-3-(tert-butylcarba...)
Affinity DataKi:  0.0400nM ΔG°:  -59.3kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108294(US8604046, 74)
Affinity DataKi:  0.0400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM9183((2R,4S)-2-benzyl-5-[(3S,5R)-3,5-dibenzyl-2-oxopyrr...)
Affinity DataKi:  0.0500nM ΔG°:  -58.8kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108295(US8604046, 75)
Affinity DataKi:  0.0600nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108284(US8604046, 64)
Affinity DataKi:  0.0600nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM517((2S)-1-[(2S,4R)-4-benzyl-2-hydroxy-4-{[(1S,2R)-2-h...)
Affinity DataKi:  0.0700nM ΔG°:  -58.0kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108282(US8604046, 62)
Affinity DataKi:  0.0700nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108310(US8604046, 90)
Affinity DataKi:  0.0800nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108328(US8604046, 108)
Affinity DataKi:  0.0900nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108316(US8604046, 96)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108303(US8604046, 83)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108296(US8604046, 76)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108305(US8604046, 85)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi: <0.100nMAssay Description:Binding affinity to HIV-1 protease was determinedMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108283(US8604046, 63)
Affinity DataKi:  0.100nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108317(US8604046, 97)
Affinity DataKi:  0.150nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108304(US8604046, 84)
Affinity DataKi:  0.150nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108311(US8604046, 91)
Affinity DataKi:  0.200nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108292(US8604046, 72)
Affinity DataKi:  0.200nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108293(US8604046, 73)
Affinity DataKi:  0.200nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108309(US8604046, 89)
Affinity DataKi:  0.240nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108299(US8604046, 79)
Affinity DataKi:  0.300nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108288(US8604046, 68)
Affinity DataKi:  0.400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108291(US8604046, 71)
Affinity DataKi:  0.400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108290(US8604046, 70)
Affinity DataKi:  0.400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108306(US8604046, 86)
Affinity DataKi:  0.400nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108287(US8604046, 67)
Affinity DataKi:  0.5nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM9225((2R,4S)-2-benzyl-5-[(3R,5R)-3,5-dibenzyl-2-oxopyrr...)
Affinity DataKi: >0.5nM ΔG°: >-53.1kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM9235((2S)-N-(cyclopentylmethyl)-3-[(3S,5R)-3,5-dibenzyl...)
Affinity DataKi:  0.5nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108308(US8604046, 88)
Affinity DataKi:  0.5nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetGag-Pol polyprotein [489-587](Human immunodeficiency virus type 1)
Glaxosmithkline

Curated by ChEMBL
LigandPNGBDBM577((3S)-oxolan-3-yl N-[(2S,3R)-4-[(4-aminobenzene)(2-...)
Affinity DataKi:  0.600nMAssay Description:Compound was assayed for inhibition against HIV protease activityMore data for this Ligand-Target Pair
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108268(US8604046, 48)
Affinity DataKi:  0.600nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108307(US8604046, 87)
Affinity DataKi:  0.600nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetOxytocin receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM50406692(CHEMBL2112249)
Affinity DataKi:  0.700nMAssay Description:Compound was evaluated for OT receptor affinity by displacement of [3H]OT from binding sites in uterine tissue taken from pregnant ratsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetOxytocin receptor(RAT)
Merck Research Laboratories

Curated by ChEMBL
LigandPNGBDBM81891(CAS_188397 | L-366,948 | NSC_188397)
Affinity DataKi:  0.700nMMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetHistamine H3 receptor(Macaca mulatta (Rhesus macaque))
Sanofi

US Patent
LigandPNGBDBM108289(US8604046, 69)
Affinity DataKi:  0.700nMAssay Description:The compounds of this invention have been demonstrated to displace [3H]- methylhistamine radioligand binding to mammalian cell membranes expressing r...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetDimer of Gag-Pol polyprotein [501-599,Q508K,L534I,L564I,C568A,C596A](Human immunodeficiency virus type 1)
Glaxosmithkline

LigandPNGBDBM9229((2R,4S)-2-benzyl-5-[(3S)-3,5-dibenzyl-1,1-dioxo-1,...)
Affinity DataKi:  0.800nM ΔG°:  -51.9kJ/molepH: 6.4 T: 2°CAssay Description:The Ki values were determined using fluorogenic substrate, 2-(aminobenzoyl)-Thr-Ile-Nle-Phe(p-NO2)-Gln-ArgNH2. A standard curve relating changes in f...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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