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Found 386 with Last Name = 'valdez' and Initial = 'l'
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  0.200nM ΔG°:  -51.5kJ/mole IC50:  0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340671(5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-di...)
Affinity DataKi:  0.400nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  0.600nM ΔG°:  -48.9kJ/mole IC50:  1.10nM EC50:  5nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340660(CHEMBL1762210 | rac-5,7-difluoro-3-hydroxy-2,2-dim...)
Affinity DataKi:  0.600nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  0.700nM ΔG°:  -48.6kJ/mole IC50:  0.200nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340666(6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-3-hydroxy-...)
Affinity DataKi:  0.700nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340662(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  0.800nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  1.10nM ΔG°:  -47.5kJ/mole IC50:  0.200nM EC50:  0.100nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18632((18Z)-18-{[3-(1-hydroxyethyl)thiophen-2-yl]methyli...)
Affinity DataKi:  1.20nM ΔG°:  -47.3kJ/mole IC50:  1.60nM EC50:  1.30nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  1.40nM ΔG°:  -47.0kJ/mole IC50:  0.400nM EC50:  0.300nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340668(CHEMBL1762207 | methyl 2-(5,7-difluoro-2,2-dimethy...)
Affinity DataKi:  1.5nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340664(6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2-dimeth...)
Affinity DataKi:  2nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  2.10nM ΔG°:  -46.0kJ/mole IC50:  1.40nM EC50:  0.200nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340665(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  2.20nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340663(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  2.70nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340661(CHEMBL1760023 | rac-5,7-difluoro-3-hydroxy-2,2-dim...)
Affinity DataKi:  3.80nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  4.40nM ΔG°:  -44.3kJ/mole IC50:  6.10nM EC50:  0.5nMpH: 7.5 T: 2°CAssay Description:Competitive Ligand Binding Assay- The Ki values were determined by the application of the Cheng-Prusoff equation: Ki=IC50/(1+[L]/Kd) where [L] is the...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM19190((1S,2R,10S,11S,14R,15S,17S)-14,17-dihydroxy-14-(2-...)
Affinity DataKi:  5.30nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340669(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  5.80nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340667(5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-di...)
Affinity DataKi:  7nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340672(5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-di...)
Affinity DataKi:  7nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18207((1R,2S,10S,11S,13R,14R,15S,17S)-1-fluoro-14,17-dih...)
Affinity DataKi:  7.20nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  10nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  21nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(CHEMBL1762210 | rac-5,7-difluoro-3-hydroxy-2,2-dim...)
Affinity DataKi:  27nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340670(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  31nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  38nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  42nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  48nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  57nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340664(6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2-dimeth...)
Affinity DataKi:  90nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18623((18Z)-12-methoxy-18-({3-[(1E)-1-(methoxyimino)ethy...)
Affinity DataKi:  110nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  150nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18617((18Z)-12-methoxy-18-{[3-(methoxymethyl)thiophen-2-...)
Affinity DataKi:  190nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340665(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  220nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340662(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  290nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  290nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  290nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18626((18Z)-12-methoxy-3,5,5-trimethyl-18-({3-[(2E)-pent...)
Affinity DataKi:  346nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlucocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM50340674(5,7-difluoro-6-(1H-indol-7-yl)-2,2-dimethyl-2,3-di...)
Affinity DataKi:  370nMAssay Description:Displacement of radiolabeled dexamethasone from glucocorticoid receptor expressed in baculovirusMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340663(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  380nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18632((18Z)-18-{[3-(1-hydroxyethyl)thiophen-2-yl]methyli...)
Affinity DataKi:  410nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340660(CHEMBL1762210 | rac-5,7-difluoro-3-hydroxy-2,2-dim...)
Affinity DataKi:  430nMAssay Description:Binding affinity to androgen receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340664(6-(3-chloro-1H-indol-7-yl)-5,7-difluoro-2,2-dimeth...)
Affinity DataKi:  570nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18628((18Z)-12-methoxy-3,5,5-trimethyl-18-{[3-(2,2,2-tri...)
Affinity DataKi:  670nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18622((18Z)-18-({3-[(1E)-1-(hydroxyimino)ethyl]thiophen-...)
Affinity DataKi:  790nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProgesterone receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340662(5,7-difluoro-2,2-dimethyl-6-(3-methyl-1H-indol-7-y...)
Affinity DataKi:  950nMAssay Description:Binding affinity to progesterone receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMineralocorticoid receptor(Homo sapiens (Human))
Ligand Pharmaceuticals

LigandPNGBDBM18616((18Z)-18-{[3-(hydroxymethyl)thiophen-2-yl]methylid...)
Affinity DataKi:  980nMAssay Description:The procedure for the cross reactivity receptor binding assays was using baculovirus-expressed receptors. After correcting for nonspecific binding, I...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNociceptin receptor(Homo sapiens (Human))
Dart Neuroscience

US Patent
LigandPNGBDBM558094(US11365191, Example 182)
Affinity DataKi: >1.00E+3nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetNociceptin receptor(Homo sapiens (Human))
Dart Neuroscience

US Patent
LigandPNGBDBM558072(US11365191, Example 12)
Affinity DataKi: >1.00E+3nMAssay Description:Formula (I) compounds were tested for antagonism of the nociceptin receptor (NOP) in a cell-based cAMP assay, using the LANCE cAMP Detection Kit, Per...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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