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Found 188 with Last Name = 'varrone' and Initial = 'm'
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM21393(7-(dipropylamino)-5,6,7,8-tetrahydronaphthalen-1-o...)
Affinity DataKi:  3.40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420342(CHEMBL2089156)
Affinity DataKi:  5.80nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50419878(CHEMBL1956195)
Affinity DataKi:  10nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM13211((3S,6S,9aS)-6-[(2S)-2-aminobutanamido]-N-(diphenyl...)
Affinity DataKi:  25nM ΔG°:  -43.1kJ/mole IC50:  460nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50412245(CHEMBL495095)
Affinity DataKi:  28nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417343(CHEMBL1276140)
Affinity DataKi:  35nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50419878(CHEMBL1956195)
Affinity DataKi:  36nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420341(CHEMBL2089155)
Affinity DataKi:  40nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420342(CHEMBL2089156)
Affinity DataKi:  42nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50319673(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Affinity DataKi:  44nMAssay Description:Displacement of [3H]epibatidine from rat alpha7 nAChR expressed in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420341(CHEMBL2089155)
Affinity DataKi:  45nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417343(CHEMBL1276140)
Affinity DataKi:  52nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50412245(CHEMBL495095)
Affinity DataKi:  58nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM13212((3S,6S,9aS)-N-(diphenylmethyl)-6-[(2S)-2-(methylam...)
Affinity DataKi:  61nM ΔG°:  -40.9kJ/mole IC50:  530nMpH: 7.5 T: 2°CAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417343(CHEMBL1276140)
Affinity DataKi:  71nMAssay Description:Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor mic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50412245(CHEMBL495095)
Affinity DataKi:  85nMAssay Description:Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2A adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417342(CHEMBL1276139)
Affinity DataKi:  100nMAssay Description:Displacement of [3H]RX821002 from human alpha2A adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50019646(2-(alpha-(2,6-Dichlorophenoxy)ethyl)2-imidazoline ...)
Affinity DataKi:  126nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417342(CHEMBL1276139)
Affinity DataKi:  178nMAssay Description:Agonist activity at human alpha2C adrenoceptor expressed in CHO cells assessed as extracellular acidification measured after 4 mins by cytosensor mic...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420341(CHEMBL2089155)
Affinity DataKi:  234nMAssay Description:Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetNeuronal acetylcholine receptor subunit alpha-7(Rattus norvegicus (Rat))
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50300802(5-Morpholin-4-ylpentanoic acid(4-pyridin-3-ylpheny...)
Affinity DataKi:  260nMAssay Description:Displacement of [3H]epibatidine from rat rat alpha7 nAChR expressed in rat GH4C1 cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50419878(CHEMBL1956195)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2C adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420342(CHEMBL2089156)
Affinity DataKi:  275nMAssay Description:Displacement of [3H]RX821002 from human alpha2C adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420341(CHEMBL2089155)
Affinity DataKi:  339nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50412245(CHEMBL495095)
Affinity DataKi:  339nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417343(CHEMBL1276140)
Affinity DataKi:  398nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50419878(CHEMBL1956195)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50420342(CHEMBL2089156)
Affinity DataKi:  407nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAlpha-2B adrenergic receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417342(CHEMBL1276139)
Affinity DataKi:  562nMAssay Description:Displacement of [3H]RX821002 from human alpha2B adrenoceptor expressed in CHO cells after 30 mins by scintillation countingMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50016897(2-(2,6-dichloroanilino)-1,3-diazacyclopentene-(2) ...)
Affinity DataKi:  3.24E+3nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 4(Homo sapiens (Human))
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50319673(1-[6-(4-Fluorophenyl)pyridin-3-yl]-3-(4-piperidin-...)
Affinity DataKi:  6.00E+3nMAssay Description:Binding affinity to 5HT4 receptorMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target5-hydroxytryptamine receptor 1A(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50417342(CHEMBL1276139)
Affinity DataKi: <1.00E+4nMAssay Description:Displacement of [3H]8-OH-DPAT from human 5HT1A receptor expressed in HeLa cells after 30 minsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-2(Homo sapiens (Human))
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50441357(CHEMBL2431805)
Affinity DataIC50:  4nMAssay Description:Inhibition of GST-tagged Tankyrases 2 (unknown origin) by autoPARsylationassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPoly [ADP-ribose] polymerase tankyrase-1(Homo sapiens (Human))
Siena Biotech

Curated by ChEMBL
LigandPNGBDBM50441357(CHEMBL2431805)
Affinity DataIC50:  11nMAssay Description:Inhibition of GST-tagged Tankyrases 1 (unknown origin) by autoPARsylationassayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32615(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 40d)
Affinity DataIC50:  27nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32589(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 18b | 1-...)
Affinity DataIC50:  35nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetBaculoviral IAP repeat-containing protein 3(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32589(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 18b | 1-...)
Affinity DataIC50:  49nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32582(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 4b)
Affinity DataIC50:  54nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32601(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 26d)
Affinity DataIC50:  54nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32603(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 28b)
Affinity DataIC50:  54nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32609(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 36b)
Affinity DataIC50:  55nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32588(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 18a | 1-...)
Affinity DataIC50:  56nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32595(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 22c | 1-...)
Affinity DataIC50:  58nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32611(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 38b)
Affinity DataIC50:  60nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32606(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 34a)
Affinity DataIC50:  70nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32613(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 40b)
Affinity DataIC50:  70nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32589(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 18b | 1-...)
Affinity DataIC50:  72nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32599(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 26b | 1-...)
Affinity DataIC50:  75nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32600(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 26c)
Affinity DataIC50:  83nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetE3 ubiquitin-protein ligase XIAP(Homo sapiens (Human))
Universita Degli Studi Di Milano

LigandPNGBDBM32605(1-aza-2-oxobicyclo[5.3.0]decane scaffold, 32b)
Affinity DataIC50:  85nMAssay Description:Fluorescence polarization was measured on an Ultra plate reader (Tecan) at excitation and emission wavelengths of 485 and 530 nm, respectively. The e...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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