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Found 77 with Last Name = 'vermeulen' and Initial = 'j'
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214016(CHEMBL243342 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  230nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214007(CHEMBL394621 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  240nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214001(CHEMBL389494 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  290nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214008(CHEMBL243343 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  340nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214003(CHEMBL243134 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  390nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214000(CHEMBL243180 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  450nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214004(CHEMBL243116 | N-(4-((1-(2-fluorobenzyl)-3-butyl-2...)
Affinity DataIC50:  540nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214014(CHEMBL245018 | N-(4-((1-(2-fluorobenzyl)-3-butyl-2...)
Affinity DataIC50:  630nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214010(CHEMBL244165 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  690nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214012(CHEMBL394368 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  790nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214009(3-(cyclopropylmethyl)-8-({4-[(dimethylsulfamoyl)am...)
Affinity DataIC50:  960nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214002(CHEMBL244590 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  1.25E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214015(1-(2-fluorobenzyl)-8-(4-aminobenzyl)-3-(cyclopropy...)
Affinity DataIC50:  1.56E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214006(CHEMBL397513 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  1.80E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214013(CHEMBL242486 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  1.95E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214017(CHEMBL244589 | N-(4-((1-(2-fluorobenzyl)-3-(cyclop...)
Affinity DataIC50:  2.07E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50133801(CHEMBL120708 | N-(4-((1-(2-fluorobenzyl)-3-butyl-2...)
Affinity DataIC50:  2.11E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214018(CHEMBL428567 | N-(4-((1-(2-fluorobenzyl)-3-butyl-2...)
Affinity DataIC50:  2.30E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214011(1-(2-fluorobenzyl)-8-(4-aminobenzyl)-3-butyl-1H-pu...)
Affinity DataIC50:  2.56E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214019(8-(2,4-diaminobenzyl)-1-(2-fluorobenzyl)-3-butyl-1...)
Affinity DataIC50:  5.65E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetPhosphoenolpyruvate carboxykinase, cytosolic [GTP](Homo sapiens (Human))
Roche Research Center

Curated by ChEMBL
LigandPNGBDBM50214005(CHEMBL242437 | N-{3-acetylamino-4-[3-butyl-1-(2-fl...)
Affinity DataIC50:  8.70E+3nMAssay Description:Inhibition of human cPEPCKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C9(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataIC50:  2.20E+4nMAssay Description:Inhibition of CYP2C9 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 2C19(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP2C19 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A5(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A5 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataIC50: >5.00E+4nMAssay Description:Inhibition of CYP3A4 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012817(CHEMBL3261330 | USRE46024, 19)
Affinity DataEC50:  6.98E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012859(CHEMBL3261319 | USRE46024, 2)
Affinity DataEC50:  7.01E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012901(CHEMBL3261320 | USRE46024, 4)
Affinity DataEC50:  7.01E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012902(CHEMBL3261318 | USRE46024, 1)
Affinity DataEC50:  7.75E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012903(CHEMBL3261328 | USRE46024, 17)
Affinity DataEC50:  8.88E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012904(CHEMBL3261329)
Affinity DataEC50:  9.17E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012859(CHEMBL3261319 | USRE46024, 2)
Affinity DataEC50:  1.20E+4nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012817(CHEMBL3261330 | USRE46024, 19)
Affinity DataEC50:  1.44E+4nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012902(CHEMBL3261318 | USRE46024, 1)
Affinity DataEC50:  1.56E+4nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012906(CHEMBL3261323 | USRE46024, 10)
Affinity DataEC50:  780nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012907(CHEMBL3261336 | USRE46024, 13)
Affinity DataEC50:  820nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012908(CHEMBL3261334 | USRE46024, 22)
Affinity DataEC50:  1.25E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012903(CHEMBL3261328 | USRE46024, 17)
Affinity DataEC50:  2.04E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012910(CHEMBL3261326 | USRE46024, 14)
Affinity DataEC50:  2.99E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012901(CHEMBL3261320 | USRE46024, 4)
Affinity DataEC50:  2.38E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012911(CHEMBL3261332 | USRE46024, 12)
Affinity DataEC50:  2.75E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012912(CHEMBL3261321 | USRE46024, 3)
Affinity DataEC50:  3.28E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataEC50:  3.74E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012910(CHEMBL3261326 | USRE46024, 14)
Affinity DataEC50:  4.29E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50115668(3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phen...)
Affinity DataEC50:  3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataEC50:  5nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataEC50:  10nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18860((2R)-2-amino-3-[4-(4-hydroxy-3-iodophenoxy)-3,5-di...)
Affinity DataEC50:  15nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50115668(3,5-dimethyl-4-(4'-hydroxy-3'-isopropylbenzyl)phen...)
Affinity DataEC50:  18nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
TargetThyroid hormone receptor beta(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM18869(2-{3,5-dichloro-4-[4-hydroxy-3-(propan-2-yl)phenox...)
Affinity DataEC50:  23nMAssay Description:Agonist activity at recombinant His6-tagged THR-beta (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 m...More data for this Ligand-Target Pair
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