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Found 4 Enz. Inhib. hit(s) with Target = 'Thyroid hormone receptor alpha' and Ligand = 'BDBM50012905'
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataEC50:  3.74E+3nMAssay Description:Agonist activity at recombinant His6-tagged THR-alpha (unknown origin) expressed in Escherichia coli BL21(DE3) co-expressing RXR preincubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataEC50:  2.85E+3nMAssay Description:Agonist activity at human THRalpha transfected in Huh7 cells co-transfected with luciferase reporter plasmid assessed as reduction in luciferase acti...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataEC50:  7.90E+3nMAssay Description:Huh7 cells were cultured in a DMEM medium supplemented with 10% FBS. The cells were inoculated into a 10 cm cell culture dish, proliferated to about ...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetThyroid hormone receptor alpha(Homo sapiens (Human))
Madrigal Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50012905(CHEMBL3261331 | US20240059676, Compound MGL-3196 |...)
Affinity DataEC50:  2.74E+3nMAssay Description:Agonist activity at wild type human TR alpha LBD expressed in Escherichia coli BL21 (DE3) assessed as induction of N-terminal biotinylated coactivato...More data for this Ligand-Target Pair
In DepthDetails PubMed