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Found 335 with Last Name = 'vincent' and Initial = 'm'
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051495((S)-2-[(S)-2-(2-Hydroxy-acetyl)-pyrrolidine-1-carb...)
Affinity DataIC50:  0.100nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat brainMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051520(CHEMBL305681 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carb...)
Affinity DataIC50:  0.900nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051511(CHEMBL80684 | [(1R,2S)-2-(4-Fluoro-phenyl)-cyclopr...)
Affinity DataIC50:  1.10nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051523(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Affinity DataIC50:  1.20nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Institut De Chimie Des Substances Naturelles

Curated by ChEMBL
LigandPNGBDBM50367254(ENALAPRILAT)
Affinity DataIC50:  1.20nMAssay Description:In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residuesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051504(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(th...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051515(CHEMBL80698 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carbo...)
Affinity DataIC50:  1.30nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051506(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051516(CHEMBL79213 | [(2S,3aS,7aS)-2-(Pyrrolidine-1-carbo...)
Affinity DataIC50:  1.40nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Institut De Chimie Des Substances Naturelles

Curated by ChEMBL
LigandPNGBDBM50011362(1-(3-Mercapto-2-methyl-propionyl)-pyrrolidine-2-ca...)
Affinity DataIC50:  1.5nMAssay Description:In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residuesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Institut De Chimie Des Substances Naturelles

Curated by ChEMBL
LigandPNGBDBM50011365(1-[2-(1-Carboxy-butylamino)-propionyl]-octahydro-i...)
Affinity DataIC50:  1.5nMAssay Description:In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residuesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Institut De Chimie Des Substances Naturelles

Curated by ChEMBL
LigandPNGBDBM50011361(1-[2-(1-Carboxy-butylamino)-acetyl]-octahydro-indo...)
Affinity DataIC50:  1.90nMAssay Description:In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residuesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051508(CHEMBL75968 | [(2S,3aS,7aS)-2-(Isoxazolidine-2-car...)
Affinity DataIC50:  2nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051489(((1R,2S)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Affinity DataIC50:  2.30nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051483(CHEMBL80865 | [(2S,3aS,7aS)-2-(2,5-Dihydro-pyrrole...)
Affinity DataIC50:  2.40nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051544(CHEMBL311848 | [(2S,3aS,7aS)-2-(2,3-Dihydro-pyrrol...)
Affinity DataIC50:  2.70nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051513(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(thiazolidin...)
Affinity DataIC50:  3.10nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051496(CHEMBL310228 | [(S)-3-(Pyrrolidine-1-carbonyl)-2-a...)
Affinity DataIC50:  3.20nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051537(CHEMBL80136 | [(1R,2S)-2-(4-Fluoro-phenyl)-cyclopr...)
Affinity DataIC50:  4nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051543((2-Benzyl-cyclopropyl)-[(S)-3-(pyrrolidine-1-carbo...)
Affinity DataIC50:  4.20nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051484(CHEMBL307938 | [(S)-3-(Pyrrolidine-1-carbonyl)-2-a...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051484(CHEMBL307938 | [(S)-3-(Pyrrolidine-1-carbonyl)-2-a...)
Affinity DataIC50:  4.80nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticamMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051486(((1R,2S)-2-Naphthalen-2-yl-cyclopropyl)-[(S)-3-(py...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051488(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b(Candida albicans (Yeast))
Massachusetts Institute of Technology

LigandPNGBDBM192008(Antimycin A | [(2R,3S,6S,7R)-3-[(3-formamido-2-hyd...)
Affinity DataIC50:  5nMpH: 7.4 T: 2°CAssay Description:The cytochrome b enzyme assay was adapted from previous studies (Gutierrez-Cirlos et al., 2004). Briefly, compounds were diluted in a 23 reaction buf...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051518(6,6,6-Trifluoro-5-phenyl-1-[(2S,3aS,7aS)-2-(pyrrol...)
Affinity DataIC50:  5nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50454200(CHEMBL2369824)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051540((R)-3-(Pyrrolidine-1-carbonyl)-2-aza-bicyclo[2.2.1...)
Affinity DataIC50:  5.5nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b(Homo sapiens (Human))
Massachusetts Institute of Technology

LigandPNGBDBM192008(Antimycin A | [(2R,3S,6S,7R)-3-[(3-formamido-2-hyd...)
Affinity DataIC50:  7nMpH: 7.4 T: 2°CAssay Description:The cytochrome b enzyme assay was adapted from previous studies (Gutierrez-Cirlos et al., 2004). Briefly, compounds were diluted in a 23 reaction buf...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051487(5,5-Dicyclopropyl-1-[(S)-3-(pyrrolidine-1-carbonyl...)
Affinity DataIC50:  9nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051491(CHEMBL77149 | [(2S,3aS,7aS)-2-(3-Hydroxy-pyrrolidi...)
Affinity DataIC50:  11nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051506(((1R,2S)-2-Phenyl-cyclopropyl)-[(S)-3-(pyrrolidine...)
Affinity DataIC50:  14nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051481(CHEMBL306957 | [(1R,2S)-2-(4-Methoxy-phenyl)-cyclo...)
Affinity DataIC50:  16nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051542(5,5-Dicyclopropyl-1-[(2S,3aS,7aS)-2-(pyrrolidine-1...)
Affinity DataIC50:  17nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051536(6,6-Dicyclopropyl-1-[(S)-3-(pyrrolidine-1-carbonyl...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051512((R)-3-(2,5-Dihydro-pyrrole-1-carbonyl)-2-aza-bicyc...)
Affinity DataIC50:  20nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAngiotensin-converting enzyme(Oryctolagus cuniculus)
Institut De Chimie Des Substances Naturelles

Curated by ChEMBL
LigandPNGBDBM50011367(1-(3-Mercapto-2-methyl-propionyl)-pyrrolidine-2-ca...)
Affinity DataIC50:  23nMAssay Description:In vitro activity against angiotensin I converting enzyme especially against Hip-His-Leu residuesMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051510((R)-3-(Pyrrolidine-1-carbonyl)-2-aza-bicyclo[2.2.2...)
Affinity DataIC50:  23nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051546((E)-6,6-Dicyclopropyl-1-[(S)-3-(pyrrolidine-1-carb...)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051517((R)-3-(Thiazolidine-3-carbonyl)-2-aza-bicyclo[2.2....)
Affinity DataIC50:  24nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051509(5,5-Dicyclopropyl-1-[(S)-3-(pyrrolidine-1-carbonyl...)
Affinity DataIC50:  26nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b(Candida albicans (Yeast))
Massachusetts Institute of Technology

LigandPNGBDBM192013(Inz-4)
Affinity DataIC50:  26nMpH: 7.4 T: 2°CAssay Description:The cytochrome b enzyme assay was adapted from previous studies (Gutierrez-Cirlos et al., 2004). Briefly, compounds were diluted in a 23 reaction buf...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051479((3-Phenyl-cyclobutyl)-[(S)-3-(pyrrolidine-1-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051505(4-Phenyl-1-[(R)-3-(pyrrolidine-1-carbonyl)-2-aza-b...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051479((3-Phenyl-cyclobutyl)-[(S)-3-(pyrrolidine-1-carbon...)
Affinity DataIC50:  27nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051550((3aS,7aS)-2-(Azetidine-1-carbonyl)-octahydro-indol...)
Affinity DataIC50:  30nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051547((S)-2-(Pyrrolidine-1-carbonyl)-pyrrolidine-1-carbo...)
Affinity DataIC50:  32nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Rattus norvegicus)
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051527(((1S,2R)-2-Phenyl-cyclopropyl)-[(2S,3aS,7aS)-2-(py...)
Affinity DataIC50:  33nMAssay Description:Inhibitory activity of the compound was evaluated against Post-proline cleaving enzyme from rat cortexMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProlyl endopeptidase(Homo sapiens (Human))
Institut De Recherche Servier

Curated by ChEMBL
LigandPNGBDBM50051534(4-Phenyl-1-[(2R,3aS,7aS)-2-(pyrrolidine-1-carbonyl...)
Affinity DataIC50:  34nMAssay Description:Inhibitory activity evaluated against Post-proline cleaving enzyme from Flavobacterium meningosepticumMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome b(Candida albicans (Yeast))
Massachusetts Institute of Technology

LigandPNGBDBM192077(Inz-68)
Affinity DataIC50:  35.2nMpH: 7.4 T: 2°CAssay Description:The cytochrome b enzyme assay was adapted from previous studies (Gutierrez-Cirlos et al., 2004). Briefly, compounds were diluted in a 23 reaction buf...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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