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Found 1472 with Last Name = 'wallace' and Initial = 'em'
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136465(US8865726, 96)
Affinity DataIC50:  0.510nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136478(US8865726, 109)
Affinity DataIC50:  0.510nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136474(US8865726, 105 | US8865726, 140)
Affinity DataIC50:  0.510nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192361(US9187462, I-41)
Affinity DataIC50:  0.550nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192386(US9187462, I-66)
Affinity DataIC50:  0.600nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291559(CHEMBL268473 | {2-Benzo[1,3]dioxol-5-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192385(US9187462, I-65)
Affinity DataIC50:  0.600nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291555(CHEMBL276690 | {2-Benzo[1,3]dioxol-4-yl-1-[(S)-2-b...)
Affinity DataIC50:  0.700nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291558(CHEMBL276872 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  0.740nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136496(US8865726, 127)
Affinity DataIC50:  0.790nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192322(US9187462, I-2)
Affinity DataIC50:  0.800nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136472(US8865726, 103)
Affinity DataIC50:  0.870nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  0.900nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetNeprilysin(Rattus norvegicus (Rat))
Novartis Institute For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  1nMAssay Description:In vitro inhibition of rat neutral endopeptidaseMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50398382(CHEMBL2177387)
Affinity DataIC50:  1nMAssay Description:Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192364(US9187462, I-44)
Affinity DataIC50:  1nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50064106(CGS-26303 | CHEMBL290698 | {[(R)-2-Biphenyl-4-yl-1...)
Affinity DataIC50:  1nMAssay Description:Inhibitory activity against neutral endopeptidase (NEP).More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192352(US9187462, I-32)
Affinity DataIC50:  1.10nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192368(US9187462, I-48)
Affinity DataIC50:  1.10nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192436(US9187462, II-46)
Affinity DataIC50:  1.10nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192359(US9187462, I-39)
Affinity DataIC50:  1.20nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136464(US8865726, 95)
Affinity DataIC50:  1.20nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192388(BDBM192402 | US9187462, I-68)
Affinity DataIC50:  1.20nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192335(US9187462, I-15)
Affinity DataIC50:  1.20nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192403(US9187462, II-13)
Affinity DataIC50:  1.20nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192389(US9187462, I-69)
Affinity DataIC50:  1.20nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136482(US8865726, 113)
Affinity DataIC50:  1.30nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192437(US9187462, II-47)
Affinity DataIC50:  1.30nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192388(BDBM192402 | US9187462, I-68)
Affinity DataIC50:  1.30nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192342(US9187462, I-22)
Affinity DataIC50:  1.40nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192332(US9187462, I-12)
Affinity DataIC50:  1.40nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192438(US9187462, II-48)
Affinity DataIC50:  1.40nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192367(US9187462, I-47)
Affinity DataIC50:  1.40nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetNeprilysin(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50291557(CHEMBL268761 | {1-[(S)-2-Biphenyl-4-yl-1-(1H-tetra...)
Affinity DataIC50:  1.5nMAssay Description:Inhibition of neutral endopeptidase 24.11(NEP)More data for this Ligand-Target Pair
In DepthDetails Article
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192353(US9187462, I-33)
Affinity DataIC50:  1.5nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192443(US9187462, II-53)
Affinity DataIC50:  1.5nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136385(US8865726, 16)
Affinity DataIC50:  1.5nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136441(US8865726, 72)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136501(US8865726, 132)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192356(US9187462, I-36)
Affinity DataIC50:  1.60nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136431(US8865726, 62)
Affinity DataIC50:  1.60nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136466(US8865726, 97)
Affinity DataIC50:  1.70nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136384(US8865726, 15)
Affinity DataIC50:  1.70nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136487(US8865726, 118)
Affinity DataIC50:  1.70nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192351(US9187462, I-31)
Affinity DataIC50:  1.70nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192327(US9187462, I-7)
Affinity DataIC50:  1.80nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetMitogen-activated protein kinase 1 [8-360](Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM192442(US9187462, II-52)
Affinity DataIC50:  1.90nMpH: 7.3Assay Description:Compounds were tested in an enzymatic assay using human ERK-2 (Mitogen Activated Kinase 1), recombinantly expressed as an N-terminal 6-His fusion pro...More data for this Ligand-Target Pair
In DepthDetails US Patent
TargetVascular endothelial growth factor A(Homo sapiens (Human))
Peloton Therapeutics

US Patent
LigandPNGBDBM282581(4-Bromo-5-(3-chloro-5-fluorophenoxy)-2,2-difluoro-...)
Affinity DataIC50:  2nMpH: 7.5Assay Description:The total assay volume was about 100 μL in the following configuration: 2-μL compound in DMSO, 88 μL buffer with protein and probe and...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetRAC-gamma serine/threonine-protein kinase(Homo sapiens (Human))
Array Biopharma

Curated by ChEMBL
LigandPNGBDBM50398358(CHEMBL2177361)
Affinity DataIC50:  2nMAssay Description:Competitive inhibition of wild-type full-length amino-terminal polyhistidine-tagged human Akt3 expressed in recombinant baculovirus system using fluo...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetSerine/threonine-protein kinase mTOR(Homo sapiens (Human))
Array Biopharma

US Patent
LigandPNGBDBM136375(US8865726, 6)
Affinity DataIC50:  2nMpH: 7.5 T: 2°CAssay Description:The ability of compounds of Formula I to inhibit mTOR was determined in a radioactive filtration assay that measures the transfer of radiolabeled pho...More data for this Ligand-Target Pair
In DepthDetails US Patent
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