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Found 5238 with Last Name = 'walsh' and Initial = 'm'
TargetATP-dependent 6-phosphofructokinase(Trypanosoma brucei)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50446088(CHEMBL3108870)
Affinity DataKi:  52nMAssay Description:Competitive inhibition Trypanosoma brucei PFK using fructose-6-phosphate as substrate by Line-weaver Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent 6-phosphofructokinase(Trypanosoma brucei)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50446088(CHEMBL3108870)
Affinity DataKi:  240nMAssay Description:Mixed type inhibition Trypanosoma brucei PFK using ATP as substrate by Line-weaver Burk plot analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189696(CHEMBL3827924)
Affinity DataKi:  4.80E+3nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189697(CHEMBL3827733)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189699(CHEMBL3827834)
Affinity DataKi:  1.00E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189698(CHEMBL3827336)
Affinity DataKi:  1.69E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189711(CHEMBL3827805)
Affinity DataKi:  2.50E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189780(CHEMBL3827954)
Affinity DataKi:  3.31E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
TargetChromobox protein homolog 7(Homo sapiens (Human))
Icahn School Of Medicine At Mount Sinai

Curated by ChEMBL
LigandPNGBDBM50189762(CHEMBL3827451)
Affinity DataKi:  3.93E+4nMAssay Description:Binding affinity to CBX7ChD (7 to 66 residues) (unknown origin) expressed in RIPL-BL21 (DE3)-CodonPlus competent cells in presence of FITC-labeled SE...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM420298(CVD-0006356 | PF-00835231 | PF-0835231 | US1152494...)
Affinity DataIC50:  0.650nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPurchasePDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM50097721(CHEMBL1879790 | EN300-11843)
Affinity DataIC50:  2nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM496902(CVD-0018409 | PF-07321332 | US11351149, Example 13...)
Affinity DataIC50:  3nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50476508(CHEMBL234487)
Affinity DataIC50:  3nMAssay Description:Inhibition of MAPK p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM50476509(CHEMBL234486)
Affinity DataIC50:  7nMAssay Description:Inhibition of MAPK p38More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50425387(CHEMBL2311806)
Affinity DataIC50:  8.20nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMitogen-activated protein kinase 11/12/13/14(Homo sapiens (Human))
Paradigm Therapeutics

Curated by ChEMBL
LigandPNGBDBM13533(1-[2-(4-methylphenyl)-5-tert-butyl-pyrazol-3-yl]-3...)
Affinity DataIC50:  9nMAssay Description:Inhibition of MAPK p38More data for this Ligand-Target Pair
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50425385(CHEMBL2311807)
Affinity DataIC50:  10nMAssay Description:Inhibition of human c-Kit using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetATP-dependent 6-phosphofructokinase(Trypanosoma brucei)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50446088(CHEMBL3108870)
Affinity DataIC50:  15nMAssay Description:Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50237710(4-methyl-N-[3-(4-methyl-1H-imidazol-1-yl)-5-(trifl...)
Affinity DataIC50:  15nMAssay Description:Inhibition of human c-Kit using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM496478(LOR-NOR-30067bb9-11)
Affinity DataIC50:  17nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetDiscoidin domain-containing receptor 2(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50425387(CHEMBL2311806)
Affinity DataIC50:  17nMAssay Description:Inhibition of human DDR2 using KKSRGDYMTMQIG peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM627791(CVD-0019230)
Affinity DataIC50:  20nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495599(CVD-0016335 | STE-KUL-d79e3d6a-3)
Affinity DataIC50:  21nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495599(CVD-0016335 | STE-KUL-d79e3d6a-3)
Affinity DataIC50:  21nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetATP-dependent 6-phosphofructokinase(Trypanosoma brucei)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50446090(CHEMBL3108868)
Affinity DataIC50:  24nMAssay Description:Inhibition of Trypanosoma brucei PFK-mediated ADP production using ATP/fructose-6-phosphate as substrate by luciferase based luminescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM496258(CVD-0013146 | JOH-MSK-46727e7b-1)
Affinity DataIC50:  26nMAssay Description:The assay was performed according to the published procedure. Briefly, compounds were seeded into assay-ready plates (Greiner 384PP, cat# 781280) usi...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetPlatelet-derived growth factor receptor alpha(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50425385(CHEMBL2311807)
Affinity DataIC50:  26nMAssay Description:Inhibition of human PDGFRalpha using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM627915(CVD-0019273)
Affinity DataIC50:  27nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM625991(EN300-11760)
Affinity DataIC50:  28nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM496258(CVD-0013146 | JOH-MSK-46727e7b-1)
Affinity DataIC50:  30nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetMast/stem cell growth factor receptor Kit(Homo sapiens (Human))
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50425386(CHEMBL2311808)
Affinity DataIC50:  33nMAssay Description:Inhibition of human c-Kit using poly[Glu:Tyr] (4:1) peptide substrateMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM626053(EN300-17406)
Affinity DataIC50:  34nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495290(CVD-0018692 | MAT-POS-e194df51-1)
Affinity DataIC50:  37nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PDB3D3D Structure (crystal)
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495290(CVD-0018692 | MAT-POS-e194df51-1)
Affinity DataIC50:  37nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM627860(CVD-0018385 | EDJ-MED-be9e6f63-3)
Affinity DataIC50:  40nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM627860(CVD-0018385 | EDJ-MED-be9e6f63-3)
Affinity DataIC50:  40nMAssay Description:This assay is for S2.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM625991(EN300-11760)
Affinity DataIC50:  40nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetATP-dependent 6-phosphofructokinase(Trypanosoma cruzi)
National Center For Advancing Translational Sciences

Curated by ChEMBL
LigandPNGBDBM50446091(CHEMBL3108867)
Affinity DataIC50:  41nMAssay Description:Inhibition of Trypanosoma cruzi PFKMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495803(CVD-0015332 | MAT-POS-e69ad64a-2)
Affinity DataIC50:  41nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495803(CVD-0015332 | MAT-POS-e69ad64a-2)
Affinity DataIC50:  42nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495598(CVD-0016334 | STE-KUL-d79e3d6a-2)
Affinity DataIC50:  44nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495598(CVD-0016334 | STE-KUL-d79e3d6a-2)
Affinity DataIC50:  44nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM627972(CVD-0019478)
Affinity DataIC50:  44nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM626189(EN300-60157)
Affinity DataIC50:  45nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495783(MAT-POS-f9802937-8)
Affinity DataIC50:  47nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495783(MAT-POS-f9802937-8)
Affinity DataIC50:  47nMAssay Description:This assay is for S2.More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM495783(MAT-POS-f9802937-8)
Affinity DataIC50:  47nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat. no. 784900) using an Echo 555 acoustic dispenser, and dimethyl sulfoxide ...More data for this Ligand-Target Pair
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM429304(CVD-0006354 | acs.jmedchem.1c00409_ST.426 | indole...)
Affinity DataIC50:  50nMAssay Description:Compounds were seeded into assay-ready plates (Greiner 384 low volume, cat 784900) using an Echo 555 acoustic dispenser, and DMSO was back-filled for...More data for this Ligand-Target Pair
In DepthDetails
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM626102(EN300-213378)
Affinity DataIC50:  50nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails PubMed
TargetReplicase polyprotein 1ab(2019-nCoV)
Cornell University

LigandPNGBDBM626053(EN300-17406)
Affinity DataIC50:  50nMAssay Description:IC50 values were determined using 12 point 2-fold dilutions (starting from 10 μM).More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails PubMed
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