TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 2.20nMAssay Description:Binding affinity to mGLUR2More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataKi: 4.5nMAssay Description:Binding affinity to mGLUR3More data for this Ligand-Target Pair
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 3nMAssay Description:Inhibition of matrix metalloproteinase-2More data for this Ligand-Target Pair
Affinity DataIC50: 6nMAssay Description:Inhibition of human matrix metalloproteinase-13More data for this Ligand-Target Pair
Affinity DataIC50: 8nMAssay Description:Inhibition of matrix metalloproteinase-3More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 14nMAssay Description:Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 20nMAssay Description:Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 21nMAssay Description:Antagonist activity at human mGLUR2 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital
Curated by ChEMBL
Massachusetts General Hospital
Curated by ChEMBL
Affinity DataIC50: 24nMAssay Description:Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
Affinity DataIC50: 65nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Anhui Medical University
Curated by ChEMBL
Anhui Medical University
Curated by ChEMBL
Affinity DataIC50: 783nMAssay Description:Inhibition of TrxR in human SGC7901 cellsMore data for this Ligand-Target Pair
TargetInterstitial collagenase(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 1.50E+3nMAssay Description:Inhibition of matrix metalloproteinase-1More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Indiana University School Of Medicine
Curated by ChEMBL
Indiana University School Of Medicine
Curated by ChEMBL
Affinity DataIC50: 2.20E+3nMAssay Description:Inhibition of matrix metalloproteinase-9More data for this Ligand-Target Pair
Affinity DataIC50: 2.34E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 4.23E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 4.61E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 5.04E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 5.37E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 5.96E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 7.14E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 7.20E+3nMAssay Description:Inhibition of matrix metalloproteinase-7More data for this Ligand-Target Pair
Affinity DataIC50: 7.62E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 8.19E+3nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 9.50E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.02E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.11E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.20E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.22E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.24E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.25E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.46E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.72E+4nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
Affinity DataIC50: 1.78E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.82E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.85E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.90E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.93E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 1.97E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.12E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.29E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.62E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 2.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 3.47E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 3.88E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Affinity DataIC50: 5.10E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair