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Found 57 with Last Name = 'wang' and Initial = 'jq'
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  2.20nMAssay Description:Binding affinity to mGLUR2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataKi:  4.5nMAssay Description:Binding affinity to mGLUR3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  3nMAssay Description:Inhibition of matrix metalloproteinase-2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  6nMAssay Description:Inhibition of human matrix metalloproteinase-13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetStromelysin-1(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  8nMAssay Description:Inhibition of matrix metalloproteinase-3More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataIC50:  14nMAssay Description:Antagonist activity at human mGLUR3 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataIC50:  20nMAssay Description:Antagonist activity at mGLUR2 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMetabotropic glutamate receptor 2(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50062522((1S,2S)-2-((S)-1-amino-1-carboxy-2-(9H-xanthen-9-y...)
Affinity DataIC50:  21nMAssay Description:Antagonist activity at human mGLUR2 expressed in RGT cells assessed as inhibition of (1S,3R)-1-aminocyclopentane-1,3-dicarboxylic acid-induced inhibi...More data for this Ligand-Target Pair
TargetMetabotropic glutamate receptor 3(Homo sapiens (Human))
Massachusetts General Hospital

Curated by ChEMBL
LigandPNGBDBM50151435((1R,2R,3R,5R,6R)-2-Amino-3-(3,4-dichloro-benzyloxy...)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at mGLUR3 expressed in CHO cells assessed as inhibition of glutamate-induced inhibition of forskolin-stimulated cAMP productionMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM8610(1-[4-(4-{[(2R,4S)-2-(2,4-dichlorophenyl)-2-(1H-imi...)
Affinity DataIC50:  65nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetThioredoxin reductase 1, cytoplasmic(Homo sapiens (Human))
Anhui Medical University

Curated by ChEMBL
LigandPNGBDBM50468676(CHEMBL4281382)
Affinity DataIC50:  783nMAssay Description:Inhibition of TrxR in human SGC7901 cellsMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInterstitial collagenase(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  1.50E+3nMAssay Description:Inhibition of matrix metalloproteinase-1More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  1.90E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrix metalloproteinase-9(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  2.20E+3nMAssay Description:Inhibition of matrix metalloproteinase-9More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124241(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...)
Affinity DataIC50:  2.34E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124240(N,N'-(biphenyl-4,4'-diyl)bis(1-benzoylpipe...)
Affinity DataIC50:  2.65E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM50346601(NSC-114945 | OLEANOLIC_ACID | Oleanolic acid | Ole...)
Affinity DataIC50:  4.23E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124246(4-(4-benzamidophenyl)-N-phenylbenzamide (25))
Affinity DataIC50:  4.61E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124239(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...)
Affinity DataIC50:  5.04E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124248(N-(6-(4-benzamidophenyl)pyridin-3-yl)benzamide (28...)
Affinity DataIC50:  5.37E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124249(4-fluoro-N-(6-(4-(4-fluorobenzamido)phenyl)pyridin...)
Affinity DataIC50:  5.96E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124250(N-(6-(4-(cyclohexanecarboxamido)phenyl)pyridin-3-y...)
Affinity DataIC50:  7.14E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetMatrilysin(Homo sapiens (Human))
Indiana University School Of Medicine

Curated by ChEMBL
LigandPNGBDBM50084289((S)-2-(4'-methoxy-biphenyl-4-sulfonylamino)-3-meth...)
Affinity DataIC50:  7.20E+3nMAssay Description:Inhibition of matrix metalloproteinase-7More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124240(N,N'-(biphenyl-4,4'-diyl)bis(1-benzoylpipe...)
Affinity DataIC50:  7.62E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM81939(CAS_52-53-9 | NSC_62969 | VERAPAMIL)
Affinity DataIC50:  8.19E+3nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMedDrugBank

TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124238(di-tert-butyl4,4'-(([1,1'-biphenyl]-4,4...)
Affinity DataIC50:  9.50E+3nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124245(Methyl 4-(4-benzamidophenyl)benzoate (23))
Affinity DataIC50:  1.02E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124247(N-(6-(4-(furan-2-carboxamido)phenyl)pyridin-3-yl)f...)
Affinity DataIC50:  1.11E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124234(N,N'-(biphenyl-4,4'-diyl)dibenzamide (3))
Affinity DataIC50:  1.20E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124243(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...)
Affinity DataIC50:  1.22E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124241(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...)
Affinity DataIC50:  1.24E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124236(N,N'-([1,1'-biphenyl]-4,4'-diyl)dicycl...)
Affinity DataIC50:  1.25E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124242(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(1-...)
Affinity DataIC50:  1.46E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  1.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetReceptor-type tyrosine-protein phosphatase F(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  1.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124237(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(3-...)
Affinity DataIC50:  1.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetCytochrome P450 3A4(Homo sapiens (Human))
Zhengzhou University

Curated by ChEMBL
LigandPNGBDBM50288831(CHEMBL4161738)
Affinity DataIC50:  1.72E+4nMAssay Description:Inhibition of recombinant human CYP3A4 in presence of NADPH generating system by fluorescence assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124249(4-fluoro-N-(6-(4-(4-fluorobenzamido)phenyl)pyridin...)
Affinity DataIC50:  1.78E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124238(di-tert-butyl4,4'-(([1,1'-biphenyl]-4,4...)
Affinity DataIC50:  1.82E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124244(N-phenyl-4-[4-(phenylcarbamoyl)phenyl]benzamide (2...)
Affinity DataIC50:  1.85E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124235(N,N'-([1,1'-biphenyl]-4,4'-diyl)bis(4-...)
Affinity DataIC50:  1.90E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124233(N‐{4‐[4‐(furan‐2‐ami...)
Affinity DataIC50:  1.93E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124249(4-fluoro-N-(6-(4-(4-fluorobenzamido)phenyl)pyridin...)
Affinity DataIC50:  1.97E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124238(di-tert-butyl4,4'-(([1,1'-biphenyl]-4,4...)
Affinity DataIC50:  2.12E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124250(N-(6-(4-(cyclohexanecarboxamido)phenyl)pyridin-3-y...)
Affinity DataIC50:  2.29E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124248(N-(6-(4-benzamidophenyl)pyridin-3-yl)benzamide (28...)
Affinity DataIC50:  2.62E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124251(3-methyl-N-(6-(4-(3-methylbutanamido)phenyl)pyridi...)
Affinity DataIC50:  2.65E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 11(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM50391109(CHEMBL179166 | Sodium orthovanadate (SOV) | Vanada...)
Affinity DataIC50:  3.47E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 6(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124233(N‐{4‐[4‐(furan‐2‐ami...)
Affinity DataIC50:  3.88E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Jiangnan University

LigandPNGBDBM124233(N‐{4‐[4‐(furan‐2‐ami...)
Affinity DataIC50:  5.10E+4nMAssay Description:IC50 values were determined by pNPP assay.More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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