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Found 224 with Last Name = 'wayland' and Initial = 'b'
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM13465((2S)-N-[(1S)-1-carbamoyl-2-{4-[(5S)-1,1,3-trioxo-1...)
Affinity DataKi:  180nMAssay Description:Inhibition constant against protein-tyrosine phosphatase 1B by PNPP enzyme assayMore data for this Ligand-Target Pair
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300312(4-amino-1,2,5-oxadiazole-3-carboximidamide | CHEMB...)
Affinity DataKi:  1.10E+3nMAssay Description:Inhibition of N-terminal his-tagged human indoleamine 2,3-dioxygenase expressed in Escherichia coli assessed as N'-formylkynurenine formation by spec...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataKi:  3.40E+4nMAssay Description:Competitive inhibition of IDO1 (unknown origin)More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13467((2R)-2-{[(1S)-1-carbamoyl-2-{4-[difluoro(phosphono...)
Affinity DataIC50:  0.400nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529386(CHEMBL4458634)
Affinity DataIC50:  0.930nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529384(CHEMBL4438376)
Affinity DataIC50:  0.990nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50: <1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM261330(US10092570, Example 352 | US9707233, 350)
Affinity DataIC50: <1nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3Kdelta in human Ramos cells assessed as reduction in AKT phosphorylation incubated for 2 hrs by Alexa flour 488 based FACS analysisMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50:  1.10nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]-ATP base...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM261317(US10376513, Example 310 | US11433071, Example 311 ...)
Affinity DataIC50:  1.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM13469(({4-[(2S)-2-carbamoyl-2-[(2S)-2-(1-{4-[difluoro(ph...)
Affinity DataIC50:  1.70nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
LigandPNGBDBM50529381(CHEMBL4446120)
Affinity DataIC50:  1.70nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529385(CHEMBL4444112)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM384664(4-((5)-1-(4-amino-3-methyl-1H-pyrazolo[3,4-d]pyrim...)
Affinity DataIC50:  1.90nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM272573(US10065963, 32c | US10376513, Example 346 | US1064...)
Affinity DataIC50:  2nMAssay Description:Inhibition of PI3Kdelta in human whole blood assessed as reduction in anti-IgE antibody-induced CD63 expression by flow cast kit methodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529388(CHEMBL4443149)
Affinity DataIC50:  2.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529391(CHEMBL4513857)
Affinity DataIC50:  2.80nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50004547(CHEMBL2216863 | US10065963, Compound 28 | US104280...)
Affinity DataIC50:  3.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529390(CHEMBL4470672)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
LigandPNGBDBM50529383(CHEMBL4570334)
Affinity DataIC50:  5.30nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50126143(Epacadostat | INCB-024360)
Affinity DataIC50:  7.40nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
LigandPNGBDBM50529389(CHEMBL4440146)
Affinity DataIC50:  8.40nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  10nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233431(CHEMBL3979473 | US9789094, 5)
Affinity DataIC50:  11nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM261140(1-{1-[5-Chloro-2-methoxy-4-methyl-3-(1-methylpiper...)
Affinity DataIC50:  11nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300306(4-Amino-N-(3-bromo-4-fluorophenyl)-N'-hydroxy-1,2,...)
Affinity DataIC50:  12nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM50529382(CHEMBL4471294)
Affinity DataIC50:  13nMAssay Description:Inhibition of PI3Kdelta (unknown origin) using D-myophosphatidylinositol 4,5-bisphosphate as substrate incubated for 120 mins by [gamma-33P]ATP based...More data for this Ligand-Target Pair
Ligand InfoKEGGPC cidPC sid
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233424(CHEMBL4076756)
Affinity DataIC50:  14nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233430(CHEMBL3955791 | US11207302, Example 2)
Affinity DataIC50:  16nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233429(CHEMBL4083203)
Affinity DataIC50:  17nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300299(4-Amino-N-(3-bromophenyl)-N'-hydroxy-1,2,5-oxadiaz...)
Affinity DataIC50:  17nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300305(4-Amino-N-(3-chloro-4-fluorophenyl)-N'-hydroxy-1,2...)
Affinity DataIC50:  19nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50300296(4-Amino-N-(3-chlorophenyl)-N'-hydroxy-1,2,5-oxadia...)
Affinity DataIC50:  19nMAssay Description:Inhibition of indoleamine 2,3-dioxygenase in IFN-gamma-stimulated human HeLa cells assessed as kynurenine formation by spectrophotometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233428(CHEMBL4072733)
Affinity DataIC50:  22nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228014(2-[4-((R)-2-{1-(3-fluoro-benzenesulfonylamino)-2-[...)
Affinity DataIC50:  22nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228013(3-fluoro-N-{1-{(R)-5-[2-(3-methanesulfonyl-phenoxy...)
Affinity DataIC50:  23nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228024(3-fluoro-N-{1-[5-(3-phenyl-propyl)-1H-imidazol-2-y...)
Affinity DataIC50:  24nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228013(3-fluoro-N-{1-{(R)-5-[2-(3-methanesulfonyl-phenoxy...)
Affinity DataIC50:  25nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13507(Isothiazolidinone (IZD) deriv. 43 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  31nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228008(2-[4-(2-{1-(3-fluoro-benzenesulfonylamino)-2-[3-me...)
Affinity DataIC50:  32nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13508(Isothiazolidinone (IZD) deriv. 44 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  34nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetIndoleamine 2,3-dioxygenase 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50233433(CHEMBL4085426)
Affinity DataIC50:  35nMAssay Description:Inhibition of IDO1 in IFN-gamma-stimulated human HeLa cells assessed as decrease in kynurenine levels after 48 hrsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228038(3-fluoro-N-{1-[(R)-5-(2-fluoro-benzyl)-4,5-dihydro...)
Affinity DataIC50:  38nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13493(Isothiazolidinone (IZD) deriv. 29 | N-[(1S)-1-(1H-...)
Affinity DataIC50:  40nMAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13471(({4-[(2S)-2-carbamoyl-2-[2-(1-{4-[difluoro(phospho...)
Affinity DataIC50:  42nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 1(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50228024(3-fluoro-N-{1-[5-(3-phenyl-propyl)-1H-imidazol-2-y...)
Affinity DataIC50:  43nMAssay Description:Inhibition of PTP1B by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTyrosine-protein phosphatase non-receptor type 2(Homo sapiens (Human))
Incyte

Curated by ChEMBL
LigandPNGBDBM50189675(CHEMBL436933 | N-{1-(1H-benzoimidazol-2-yl)-2-[4-(...)
Affinity DataIC50:  43nMAssay Description:Inhibition of TCPTP by pNPP assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
LigandPNGBDBM13470(Difluoromethylphosphonic acid (DFMP) deriv. 9 | [(...)
Affinity DataIC50:  46nMpH: 7.0 T: 2°CAssay Description:The activity of PTP1B enzyme was assayed with 4-nitrophenyl phosphate (pNPP) as substrate. Rate of formation of the phenolate ion was monitored at 41...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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