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Found 395 with Last Name = 'webb' and Initial = 'j'
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86054(5'-IODORESINIFERATOXIN | I-RTX)
Affinity DataKi:  0.390nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM86054(5'-IODORESINIFERATOXIN | I-RTX)
Affinity DataKi:  6.70nMMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM23515(CHEMBL573 | Niacin | Nicotinic Acid | [5, 6-3H]-ni...)
Affinity DataKi:  50nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetHydroxycarboxylic acid receptor 2(Homo sapiens (Human))
Arena Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50273099(3-(1H-tetrazol-5-yl)-1,4,5,6-tetrahydrocyclopenta[...)
Affinity DataKi:  505nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Merck Sharp and Dohme Research Laboratories

Curated by PDSP Ki Database
LigandPNGBDBM20284(CHEMBL391997 | CPZ | Capsazepine | N-[2-(4-chlorop...)
Affinity DataKi:  4.30E+3nMMore data for this Ligand-Target Pair
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50423388(CHEMBL251024)
Affinity DataIC50:  0.320nMAssay Description:Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50423387(CHEMBL437204)
Affinity DataIC50:  0.5nMAssay Description:Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50261965(5-(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropy...)
Affinity DataIC50:  16nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262113(2-((5-chloro-1H-indol-3-yl)methyl)-7-(cyclopropylm...)
Affinity DataIC50:  23nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  25nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262115(2-((5-chloro-1H-indol-3-yl)methyl)-7-(cyclopropylm...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50215445(5-(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropy...)
Affinity DataIC50:  26nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262011(5-(2-((5-chloro-1H-indol-3-yl)methyl)-7-(cycloprop...)
Affinity DataIC50:  27nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  30nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262060(2-((5-chloro-1H-indol-3-yl)methyl)-7-(cyclopropylm...)
Affinity DataIC50:  31nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262163(2-((5-chloro-1-methyl-1H-indol-3-yl)methyl)-7-(cyc...)
Affinity DataIC50:  33nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262114(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropylme...)
Affinity DataIC50:  34nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262012(5-(2-((5-chloro-1H-indol-3-yl)methyl)-7-(cycloprop...)
Affinity DataIC50:  36nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262061(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropylme...)
Affinity DataIC50:  37nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50261964(2-(2-((5-chloro-1H-indol-3-yl)methyl)-7-(cycloprop...)
Affinity DataIC50:  38nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  40nMAssay Description:Demethylase reactions and AlphaScreen assays were performed as described (Sayegh et al., 2013), with a few exceptions. All demethylase buffers contai...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080087(3-sec-Butoxy-4-(4-methanesulfonyl-phenyl)-5,5-dime...)
Affinity DataIC50:  40nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080083(3-Cyclohexyloxy-4-(4-methanesulfonyl-phenyl)-5,5-d...)
Affinity DataIC50:  40nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50261966(5-(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropy...)
Affinity DataIC50:  44nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50261912(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropylme...)
Affinity DataIC50:  51nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262013(5-(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropy...)
Affinity DataIC50:  55nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50261913(2-((5-chloro-1-methyl-1H-indol-3-yl)methyl)-7-(cyc...)
Affinity DataIC50:  57nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50261911(3-(3-chloro-5-(methylsulfonyl)furan-2-yl)-2-((6-ch...)
Affinity DataIC50:  59nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Emory University

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  59nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM50396019(4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-...)
Affinity DataIC50:  61nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataIC50:  67nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataIC50:  74nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080080(3-(1-Cyclopropyl-ethoxy)-4-(4-methanesulfonyl-phen...)
Affinity DataIC50:  80nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2Y purinoceptor 12(Homo sapiens (Human))
Astrazeneca

Curated by ChEMBL
LigandPNGBDBM50423389(CHEMBL250832)
Affinity DataIC50:  100nMAssay Description:Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Emory University

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  100nMAssay Description:Demethylase reactions and AlphaScreen assays were performed as described (Sayegh et al., 2013), with a few exceptions. All demethylase buffers contai...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191596(6-isopropyl-5-methyl-7-oxo-4,7-dihydropyrazolo[1,5...)
Affinity DataIC50:  110nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM50396019(4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-...)
Affinity DataIC50:  120nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Emory University

LigandPNGBDBM50396019(4'-(phenethylcarbamoyl)-[2,2'-bipyridine]-...)
Affinity DataIC50:  129nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080082(3-Cyclopropylmethoxy-4-(4-methanesulfonyl-phenyl)-...)
Affinity DataIC50:  140nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetGlutamate racemase(Helicobacter pylori)
Astrazeneca R&D Boston

Curated by ChEMBL
LigandPNGBDBM50262059(2-((6-chloroquinolin-4-yl)methyl)-7-(cyclopropylme...)
Affinity DataIC50:  160nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191598(2-(((2-((2-(dimethylamino)ethyl)(ethyl)amino)-2-ox...)
Affinity DataIC50:  160nMAssay Description:Demethylase reactions and AlphaScreen assays were performed as described (Sayegh et al., 2013), with a few exceptions. All demethylase buffers contai...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  175nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5B(Homo sapiens (Human))
Emory University

LigandPNGBDBM191601(3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (...)
Affinity DataIC50:  177nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5C(Homo sapiens (Human))
Emory University

LigandPNGBDBM191597(3-((1-(2-(4,4-difluoropiperidin-1-yl)ethyl)-5-fluo...)
Affinity DataIC50:  180nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
In DepthDetails ArticlePubMed
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM17638(2-{1-[(4-chlorophenyl)carbonyl]-5-methoxy-2-methyl...)
Affinity DataIC50:  200nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191600(2-(5-((4-chloro-2-methylbenzyl)oxy)-1Hpyrazol-1-yl...)
Affinity DataIC50:  240nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080081(3-Isopropoxy-4-(4-methanesulfonyl-phenyl)-5,5-dime...)
Affinity DataIC50:  300nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191601(3-(2-(4-chlorophenyl)acetamido)isonicotinic acid (...)
Affinity DataIC50:  300nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sidPDB
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research

Curated by ChEMBL
LigandPNGBDBM50080081(3-Isopropoxy-4-(4-methanesulfonyl-phenyl)-5,5-dime...)
Affinity DataIC50:  300nMAssay Description:In vitro inhibitory potency of the compound was determined against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetLysine-specific demethylase 5A [1-1090](Homo sapiens (Human))
Emory University

LigandPNGBDBM191599(KDOAM-21 | ethyl 2-(((2-((2-(dimethylamino)ethyl)(...)
Affinity DataIC50:  303nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
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