TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
TargetTransient receptor potential cation channel subfamily V member 1(Homo sapiens (Human))
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
Affinity DataKi: 50nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
Affinity DataKi: 505nMAssay Description:Displacement of [3H]nicotinic acid from human GPR109a receptor expressed in CHO cellsMore data for this Ligand-Target Pair
TargetTransient receptor potential cation channel subfamily V member 1(Rattus norvegicus (rat))
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
Merck Sharp and Dohme Research Laboratories
Curated by PDSP Ki Database
Affinity DataIC50: 0.320nMAssay Description:Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 0.5nMAssay Description:Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 16nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 23nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 25nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 26nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 27nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 30nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 31nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 33nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 34nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 36nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 37nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 38nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 40nMAssay Description:Demethylase reactions and AlphaScreen assays were performed as described (Sayegh et al., 2013), with a few exceptions. All demethylase buffers contai...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 40nMAssay Description:In vitro inhibitory activity against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 44nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 51nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 55nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 57nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 59nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 61nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 67nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 74nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 80nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Antagonist activity at human P2Y12 receptor assessed as ADP-induced human platelet aggregationMore data for this Ligand-Target Pair
Affinity DataIC50: 100nMAssay Description:Demethylase reactions and AlphaScreen assays were performed as described (Sayegh et al., 2013), with a few exceptions. All demethylase buffers contai...More data for this Ligand-Target Pair
Affinity DataIC50: 110nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 120nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 129nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 140nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Inhibition of Helicobacter pylori MurIMore data for this Ligand-Target Pair
Affinity DataIC50: 160nMAssay Description:Demethylase reactions and AlphaScreen assays were performed as described (Sayegh et al., 2013), with a few exceptions. All demethylase buffers contai...More data for this Ligand-Target Pair
Affinity DataIC50: 175nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 177nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
Affinity DataIC50: 180nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 1(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 200nMAssay Description:Inhibitory activity against Prostaglandin G/H synthase 1 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 240nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:Inhibition of Prostaglandin G/H synthase 2 in human whole bloodMore data for this Ligand-Target Pair
Affinity DataIC50: 300nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair
TargetProstaglandin G/H synthase 2(Homo sapiens (Human))
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Merck Frosst Centre For Therapeutic Research
Curated by ChEMBL
Affinity DataIC50: 300nMAssay Description:In vitro inhibitory potency of the compound was determined against Prostaglandin G/H synthase 2 in human whole blood assayMore data for this Ligand-Target Pair
Affinity DataIC50: 303nMpH: 7.2 T: 2°CAssay Description:Reactions were performed in 50 mM HEPES [pH 7.2 for KDM5 or pH 7.5 for KDM4A(1-350)] containing 0.01% BSA and 0.01% Tween-20. To each well, 3 μL...More data for this Ligand-Target Pair