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Found 1959 with Last Name = 'weiler' and Initial = 's'
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357018(CHEMBL1914483)
Affinity DataIC50:  0.0500nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357046(CHEMBL1916834)
Affinity DataIC50:  0.300nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308093(1-[3-(2-Hydroxy-ethoxy)-benzyl]-4-(4-isopropyl-phe...)
Affinity DataIC50:  0.400nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357029(CHEMBL1916653)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357017(CHEMBL1916839)
Affinity DataIC50:  0.600nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetAndrogen receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50057651(CHEMBL3326454)
Affinity DataIC50:  0.700nMAssay Description:Displacement of [3H]DHT from androgen receptor in human MDA-MB-435 cells after 30 minsMore data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357036(CHEMBL1916661)
Affinity DataIC50:  1nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataIC50:  1.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357038(CHEMBL1916663)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357030(CHEMBL1916654)
Affinity DataIC50:  1.30nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308090(1-(3-Ethoxy-4-methoxy-benzyl)-4-(4-isopropyl-pheny...)
Affinity DataIC50:  1.40nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308081(4-(4-Isopropyl-phenyl)-1-(4-methyl-benzyl)-6-propa...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325523(2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)...)
Affinity DataIC50:  1.60nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357050(CHEMBL1916838)
Affinity DataIC50:  1.80nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308087(4-(4-Isopropyl-phenyl)-1-(3-methyl-benzyl)-6-propa...)
Affinity DataIC50:  1.80nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM8465((2R)-N-hydroxy-2-[(4-methoxybenzene)(pyridin-3-ylm...)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357022(CHEMBL1916646)
Affinity DataIC50:  2nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325525(2-((2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyet...)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357034(CHEMBL1916658)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357026(CHEMBL1916650)
Affinity DataIC50:  2.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308103(CHEMBL590539 | N-{3-[4-(4-Isopropyl-pheny)-2-oxo-6...)
Affinity DataIC50:  2.40nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308108(1-Benzyl-5-cyclopropylmethyl-6-hydroxy-4-(4-isopro...)
Affinity DataIC50:  2.5nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325524(2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)...)
Affinity DataIC50:  2.60nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308089(1-(3-Methoxy-benzyl)-4-(4-isopropyl-phenyl)-6-prop...)
Affinity DataIC50:  2.70nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357054(CHEMBL1916642)
Affinity DataIC50:  2.90nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
Target72 kDa type IV collagenase(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357018(CHEMBL1914483)
Affinity DataIC50:  3nMAssay Description:Inhibition of MMP2More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357020(CHEMBL1916644)
Affinity DataIC50:  3nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357035(CHEMBL1916660)
Affinity DataIC50:  3.20nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308091(CHEMBL597194 | {3-[4-(4-Isopropyl-phenyl)-2-oxo-6-...)
Affinity DataIC50:  3.40nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357040(CHEMBL1916665)
Affinity DataIC50:  3.60nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308106(5-Allyl-1-benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-...)
Affinity DataIC50:  3.90nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325522(4-bromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-metho...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325521(2-(4-isopropylphenyl)-7-methoxy-1-(2-methoxyethyl)...)
Affinity DataIC50:  4nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308082(1-(4-Ethyl-benzyl)-4-(4-isopropyl-phenyl)-6-propar...)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308084(4-(4-Isopropyl-phenyl)-1-(4-methoxy-benzyl)-6-prop...)
Affinity DataIC50:  4.20nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308080(1-Benzyl-4-(4-isopropyl-phenyl)-6-propargyloxy-1H-...)
Affinity DataIC50:  4.40nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451769(US10710980, Example 1 | US10947218, Example 1)
Affinity DataIC50:  5nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451772(US10710980, Example 4 | US10947218, Example 4)
Affinity DataIC50:  5nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325519(4-bromo-2-(4-isopropylphenyl)-7-methoxy-1-(2-metho...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451772(US10710980, Example 4 | US10947218, Example 4)
Affinity DataIC50:  5nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325515(5-benzyl-4-bromo-2-(4-isopropylphenyl)-7-methoxy-1...)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451769(US10710980, Example 1 | US10947218, Example 1)
Affinity DataIC50:  5nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451789(US10710980, Example 21 | US10947218, Example 21)
Affinity DataIC50:  6nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50325508(5-bromo-4-iodo-2-(4-isopropylphenyl)-7-methoxy-1-(...)
Affinity DataIC50:  6nMAssay Description:Antagonist activity at human CaSR expressed in hamster fibroblasts assessed as inhibition of calcium mobilizationMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451789(US10710980, Example 21 | US10947218, Example 21)
Affinity DataIC50:  6nMAssay Description:The assays were performed in 384-well, low volume microtiter assay plates in a final reaction volume of 6 ul. Dose-response curves were generated by ...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetExtracellular calcium-sensing receptor(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50308107(1-Benzyl-6-hydroxy-4-(4-isopropyl-phenyl)-5-propyl...)
Affinity DataIC50:  6.60nMAssay Description:Antagonist activity at human CaSR expressed in CCL39 cells assessed as inhibition of extracellular calcium-induced intracellular calcium transient by...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [172-499,R206H](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451772(US10710980, Example 4 | US10947218, Example 4)
Affinity DataIC50:  7nMAssay Description:A kinase selectivity panel which measures substrate peptide phosphorylation was set-up for wild-type ALK2 (aa172-499), ALK2 FOP mutant (aa172-499 R20...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetCollagenase 3(Homo sapiens (Human))
Novartis Institutes For Biomedical Research

Curated by ChEMBL
LigandPNGBDBM50357024(CHEMBL1916648)
Affinity DataIC50:  7nMAssay Description:Inhibition of MMP13More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451798(US10710980, Example 30 | US10947218, Example 30)
Affinity DataIC50:  7nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
TargetActivin receptor type-1 [172-499](Homo sapiens (Human))
Novartis

US Patent
LigandPNGBDBM451806(US10710980, Example 38 | US10947218, Example 38)
Affinity DataIC50:  7nMAssay Description:A kinase selectivity panel which measures autophosphorylation using the ADP-Glo Kinase Assay (Promega, V9101) was set-up for wild-type ALK2 (aa172-49...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails US Patent
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