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Found 134 with Last Name = 'werner' and Initial = 's'
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506203(CHEMBL4452312)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506156(CHEMBL4471140)
Affinity DataIC50:  2nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506173(CHEMBL4589444)
Affinity DataIC50:  5nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506179(CHEMBL4579583)
Affinity DataIC50:  8nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339062(4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...)
Affinity DataIC50:  8nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506184(CHEMBL4447043)
Affinity DataIC50:  9nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506187(CHEMBL4522504)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506180(CHEMBL4556573)
Affinity DataIC50:  10nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506201(CHEMBL4516176)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506178(CHEMBL4555657)
Affinity DataIC50:  13nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339064(5-(8-fluoro-2-phenylquinolin-7-yl)-7-(3-(4-methylp...)
Affinity DataIC50:  14nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506183(CHEMBL4521017)
Affinity DataIC50:  15nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(CHEMBL1667935 | cis-3-[4-Amino-5-(8-fluoro-2-pheny...)
Affinity DataIC50:  17nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506172(CHEMBL4563994)
Affinity DataIC50:  19nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506185(CHEMBL4438327)
Affinity DataIC50:  24nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339063(7-(3-(4-methylpiperazin-1-yl)cyclobutyl)-5-(2-phen...)
Affinity DataIC50:  25nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339061(4-(3-(4-amino-5-(2-phenylquinolin-7-yl)imidazo[1,5...)
Affinity DataIC50:  26nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506191(CHEMBL4439570)
Affinity DataIC50:  26nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506169(CHEMBL4535761)
Affinity DataIC50:  27nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506162(CHEMBL4463320)
Affinity DataIC50:  30nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506157(CHEMBL4517831)
Affinity DataIC50:  37nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506198(CHEMBL4539658)
Affinity DataIC50:  39nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506166(CHEMBL4474747)
Affinity DataIC50:  45nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339062(4-(3-(4-amino-5-(8-fluoro-2-phenylquinolin-7-yl)im...)
Affinity DataIC50:  48nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506204(CHEMBL4443234)
Affinity DataIC50:  52nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM393615(US09969700, 173)
Affinity DataIC50:  54nMAssay Description:Antagonist activity at human P2X4 receptor expressed in HEK cells assessed as reduction in ATP induced calcium influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM393615(US09969700, 173)
Affinity DataIC50:  64nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in human 1321N1 cells assessed as inhibition of ATP-induced calcium influx incubated for 15 min...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506195(CHEMBL4438981)
Affinity DataIC50:  67nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339064(5-(8-fluoro-2-phenylquinolin-7-yl)-7-(3-(4-methylp...)
Affinity DataIC50:  68nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506163(CHEMBL4561582)
Affinity DataIC50:  75nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506154(CHEMBL4516450)
Affinity DataIC50:  76nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50336317(CHEMBL1667935 | cis-3-[4-Amino-5-(8-fluoro-2-pheny...)
Affinity DataIC50:  76nMAssay Description:Inhibition of auto-phosphorylation of human IR expressed in human HepG2 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50:  79nMAssay Description:Inhibition of human IGF1R in presence of 100 uM ATPMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50:  80nMAssay Description:Inhibition of IGF-1R by ELISAMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506177(CHEMBL4452251)
Affinity DataIC50:  84nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339059(3-cyclobutyl-1-(2-phenylquinolin-7-yl)-imidazo[1,5...)
Affinity DataIC50:  86nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506175(CHEMBL4519162)
Affinity DataIC50:  88nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506186(CHEMBL4449416)
Affinity DataIC50:  92nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506164(CHEMBL4579675)
Affinity DataIC50:  93nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506160(CHEMBL4513970)
Affinity DataIC50: <100nMAssay Description:Antagonist activity at human P2X4 receptor expressed in HEK cells assessed as reduction in ATP induced calcium influxMore data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506158(CHEMBL4521594)
Affinity DataIC50:  108nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in human 1321N1 cells assessed as inhibition of Mg-ATP-induced calcium influx incubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506205(CHEMBL4469574)
Affinity DataIC50:  111nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Mus musculus)
Bayer

Curated by ChEMBL
LigandPNGBDBM50506158(CHEMBL4521594)
Affinity DataIC50:  112nMAssay Description:Antagonist activity at mouse P2X4 receptor tranfected in human 1321N1 cells assessed as inhibition of Mg-ATP-induced calcium influx incubated for 30 ...More data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506182(CHEMBL4593104)
Affinity DataIC50:  134nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506174(CHEMBL4442297)
Affinity DataIC50:  139nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetInsulin-like growth factor 1 receptor(Homo sapiens (Human))
TBA

Curated by ChEMBL
LigandPNGBDBM50339060(CHEMBL1688359 | cis-3-(4-amino-5-(2-phenylquinolin...)
Affinity DataIC50:  150nMAssay Description:Inhibition of auto-phosphorylation of human IGF1R expressed in mouse NIH-3T3 cells after 2 hrs by luminometryMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506188(CHEMBL4451946)
Affinity DataIC50:  163nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506200(CHEMBL4443857)
Affinity DataIC50:  173nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
TargetRAF proto-oncogene serine/threonine-protein kinase(Homo sapiens (Human))
Osi Pharmaceuticals

Curated by ChEMBL
LigandPNGBDBM50340954(CHEMBL1762110 | Trans-N-((-4-(8-amino-1-(1H-indol-...)
Affinity DataIC50:  180nMAssay Description:Inhibition of cRafMore data for this Ligand-Target Pair
In DepthDetails ArticlePubMed
TargetP2X purinoceptor 4(Homo sapiens (Human))
Bayer

Curated by ChEMBL
LigandPNGBDBM50506171(CHEMBL4462109)
Affinity DataIC50:  185nMAssay Description:Antagonist activity at human P2X4 receptor tranfected in HEK293 cells assessed as inhibition of Bz-ATP-induced calcium influx incubated for 30 mins a...More data for this Ligand-Target Pair
Ligand InfoPC cidPC sid
In DepthDetails ArticlePubMed
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